Imperial College London

DrJacquesBehmoaras

Faculty of MedicineDepartment of Immunology and Inflammation

Reader in Immunogenetics
 
 
 
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Contact

 

+44 (0)20 3313 2339jacques.behmoaras Website

 
 
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Location

 

9N13Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Martínez-Micaelo:2015:10.1530/JME-15-0089,
author = {Martínez-Micaelo, N and González-Abuín, N and Ardévol, A and Pinent, M and Petretto, E and Behmoaras, J and Blay, M},
doi = {10.1530/JME-15-0089},
journal = {Journal of Molecular Endocrinology},
pages = {1--10},
title = {Leptin signal transduction underlies the differential metabolic response of LEW and WKY rats to cafeteria diet},
url = {http://dx.doi.org/10.1530/JME-15-0089},
volume = {56},
year = {2015}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - Although the effect of genetic background on obesity-related phenotypes is well established, the main objective of this study is to determine the phenotypic responses to cafeteria diet (CAF) of two genetically distinct inbred rat strains and give insight into the molecular mechanisms that might be underlying. Lewis (LEW) and Wistar-Kyoto (WKY) rats were fed with either a standard or a CAF diet. The effects of the diet and the strain in the body weight gain, food intake, respiratory quotient, biochemical parameters in plasma as well as in the expression of genes that regulate leptin signalling were determined. Whereas CAF diet promoted weight gain in LEW and WKY rats, as consequence of increased energy intake, metabolic management of this energy surplus was significantly affected by genetic background. LEW and WKY showed a different metabolic profile, LEW rats showed hyperglycaemia, hypertriglyceridemia and high FFA levels, ketogenesis, high adiposity index and inflammation, but WKY did not. Leptin signalling, and specifically the LepRb-mediated regulation of STAT3 activation and Socs3 gene expression in the hypothalamus were inversely modulated by the CAF diet in LEW (upregulated) and WKY rats (downregulated). In the present study, we show evidence of gene-environment interactions in obesity exerted by differential phenotypic responses to CAF diet between LEW and WKY rats. Specifically, we found the leptin-signalling pathway as a divergent point between the strain-specific adaptations to diet.
AU - Martínez-Micaelo,N
AU - González-Abuín,N
AU - Ardévol,A
AU - Pinent,M
AU - Petretto,E
AU - Behmoaras,J
AU - Blay,M
DO - 10.1530/JME-15-0089
EP - 10
PY - 2015///
SN - 1479-6813
SP - 1
TI - Leptin signal transduction underlies the differential metabolic response of LEW and WKY rats to cafeteria diet
T2 - Journal of Molecular Endocrinology
UR - http://dx.doi.org/10.1530/JME-15-0089
VL - 56
ER -