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@article{Pereira:2018:10.1242/jcs.216267,
author = {Pereira, M and Petretto, E and Gordon, S and Bassett, JHD and Williams, GR and Behmoaras, JV},
doi = {10.1242/jcs.216267},
journal = {Journal of Cell Science},
title = {Common signalling pathways in macrophage and osteoclast multinucleation},
url = {http://dx.doi.org/10.1242/jcs.216267},
volume = {131},
year = {2018}
}

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TY  - JOUR
AB  - Macrophage cell fusion and multinucleation are fundamental processes in the formation of multinucleated giant cells (MGCs) in chronic inflammatory disease and osteoclasts in the regulation of bone mass. However, this basic cell phenomenon is poorly understood despite its pathophysiological relevance. Granulomas containing multinucleated giant cells are seen in a wide variety of complex inflammatory disorders, as well as in infectious diseases. Dysregulation of osteoclastic bone resorption underlies the pathogenesis of osteoporosis and malignant osteolytic bone disease. Recent reports have shown that the formation of multinucleated giant cells and osteoclast fusion display a common molecular signature, suggesting shared genetic determinants. In this Review, we describe the background of cell–cell fusion and the similar origin of macrophages and osteoclasts. We specifically focus on the common pathways involved in osteoclast and MGC fusion. We also highlight potential approaches that could help to unravel the core mechanisms underlying bone and granulomatous disorders in humans.
AU  - Pereira,M
AU  - Petretto,E
AU  - Gordon,S
AU  - Bassett,JHD
AU  - Williams,GR
AU  - Behmoaras,JV
DO  - 10.1242/jcs.216267
PY  - 2018///
SN  - 0021-9533
TI  - Common signalling pathways in macrophage and osteoclast multinucleation
T2  - Journal of Cell Science
UR  - http://dx.doi.org/10.1242/jcs.216267
UR  - http://hdl.handle.net/10044/1/59143
VL  - 131
ER  -

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