Imperial College London

Professor Jake Baum

Faculty of Natural SciencesDepartment of Life Sciences

Professor of Cell Biology and Infectious Diseases
 
 
 
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Contact

 

+44 (0)20 7594 5420jake.baum Website

 
 
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Location

 

609Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Summary

Throughout its complex lifecycle the malaria parasites, from the genus Plasmodium, must traverse tissues and invade a diversity of host cells to ensure successful propagation of their lifecycle. Each lifecycle stage is exquisitely designed for cell movement, tissue targeting and host cell invasion, yet we still do not understand the basic mechanics of how the parasite motor produces force and translates this into powerful movement or cell penetration. Unlike all other eukaryotic cells, the malaria parasites rely on an internal actin-myosin motor, linked through to the outside world through secreted surface adhesins across which it literally glides.

Our lab is focused on reconstructing Plasmodium gliding motor function in vitro, its regulation and in a cellular context exploring how the core factors that control motility are distributed. Our work covers the spectrum of scales from single molecule through to whole cell, biochemistry through structural biology and cell biology and, since moving to Imperial, the mysterious world of biophysics.

Ultimately our goal is to break apart Plasmodium motility at every level to generate fundamental understanding into parasite biology and identify potential targets to stop the parasite dead in its tracks!

Publications

Journals

Delves MJ, Miguel-Blanco C, Matthews H, et al., 2018, A high throughput screen for next-generation leads targeting malaria parasite transmission, Nature Communications, Vol:9, ISSN:2041-1723

Witmer K, Sherrard-Smith E, Straschil U, et al., 2018, An inexpensive open source 3D-printed membrane feeder for human malaria transmission studies, Malaria Journal, Vol:17, ISSN:1475-2875

Lythl O, Vizcay-Barrena G, Wright KE, et al., 2018, Cellular dissection of malaria parasite invasion of human erythrocytes using viable Plasmodium knowlesi merozoites, Scientific Reports, Vol:8, ISSN:2045-2322

Lubin AS, Rueda-Zubiaurre A, Matthews H, et al., 2018, Development of a Photo-Cross-Linkable Diaminoquinazoline Inhibitor for Target Identification in Plasmodium falciparum, Acs Infectious Diseases, Vol:4, ISSN:2373-8227, Pages:523-530

Malpartida-Cardenas K, Rodriguez-Manzano J, Yu L-S, et al., 2018, Allele-Specific Isothermal Amplification Method Using Unmodified Self-Stabilizing Competitive Primers., Anal Chem

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