Throughout its complex lifecycle the malaria parasites, from the genus Plasmodium, must traverse tissues and invade a diversity of host cells to ensure successful propagation of their lifecycle. Each lifecycle stage is exquisitely designed for cell movement, tissue targeting and host cell invasion, yet we still do not understand the basic mechanics of how the parasite motor produces force and translates this into powerful movement or cell penetration. Unlike all other eukaryotic cells, the malaria parasites rely on an internal actin-myosin motor, linked through to the outside world through secreted surface adhesins across which it literally glides.
Our lab is focused on reconstructing Plasmodium gliding motor function in vitro, its regulation and in a cellular context exploring how the core factors that control motility are distributed. Our work covers the spectrum of scales from single molecule through to whole cell, biochemistry through structural biology and cell biology and, since moving to Imperial, the mysterious world of biophysics.
Ultimately our goal is to break apart Plasmodium motility at every level to generate fundamental understanding into parasite biology and identify potential targets to stop the parasite dead in its tracks!
et al., 2017, Reconstitution of the core of the malaria parasite glideosome with recombinant Plasmodium class XIV myosin A and Plasmodium actin., J Biol Chem
et al., 2017, Multiple essential functions of Plasmodium falciparum actin-1 during malaria blood-stage development, Bmc Biology, Vol:15, ISSN:1741-7007
et al., 2017, Plasmodium falciparum erythrocyte-binding antigen 175 triggers a biophysical change in the red blood cell that facilitates invasion, Proceedings of the National Academy of Sciences of the United States of America, Vol:114, ISSN:0027-8424, Pages:4225-4230
et al., 2017, Hundreds of dual-stage antimalarial molecules discovered by a functional gametocyte screen, Nature Communications, Vol:8, ISSN:2041-1723
et al., 2017, Mefloquine targets the Plasmodium falciparum 80S ribosome to inhibit protein synthesis, Nature Microbiology, Vol:2, ISSN:2058-5276