Imperial College London

DrJamesMcGinty

Faculty of Natural SciencesDepartment of Physics

Senior Lecturer
 
 
 
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Contact

 

+44 (0)20 7594 7719james.mcginty

 
 
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Location

 

621Blackett LaboratorySouth Kensington Campus

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Summary

 

Publications

Publication Type
Year
to

91 results found

Talbot CB, McGinty J, Grant DM, McGhee EJ, Owen DM, Zhang W, Bunney TD, Munro I, Isherwood B, Eagle R, Hargreaves A, Katan M, Dunsby C, Neil MAA, French PMWet al., 2008, High speed unsupervised fluorescence lifetime imaging confocal multiwell plate reader for high content analysis, JOURNAL OF BIOPHOTONICS, Vol: 1, Pages: 514-521, ISSN: 1864-063X

Journal article

Talbot C, McGinty J, McGhee E, Grant D, Kumar S, Owen D, Kennedy G, Munro I, Courtney P, Zhang W, Bunney T, Magee T, Davis D, Katan M, Dunsby C, Neil M, French Pet al., 2008, High speed, optically sectioned fluorescence lifetime imaging utilizing time-gated nipkow disk or multifocal multiphoton time correlated single photon counting microscopy

We report two optically sectioned fluorescence lifetime systems that exhibit better signal to noise per unit time than conventional time correlated single photon counting systems. Both systems are applied to biologically relevant samples. ©2007 Optical Society of America.

Conference paper

McGinty J, Tahir KR, Laine R, Talbot CB, Dunsby C, Neil MAA, Quintana L, Swoger J, Sharpe J, French PMWet al., 2008, Fluorescence lifetime optical projection tomography, JOURNAL OF BIOPHOTONICS, Vol: 1, Pages: 390-394, ISSN: 1864-063X

Journal article

Galletly NP, McGinty J, Dunsby C, Teixeira F, Requejo-Isidro J, Munro I, Elson DS, Neil MAA, Chu AC, French PMW, Stamp GWet al., 2008, Fluorescence lifetime imaging distinguishes basal cell carcinoma from surrounding uninvolved skin, BRITISH JOURNAL OF DERMATOLOGY, Vol: 159, Pages: 152-161, ISSN: 0007-0963

Journal article

Grant DM, McGinty J, McGhee EJ, Bunney TD, Owen DM, Talbot CB, Zhang W, Kumar S, Munro I, Lanigan PMP, Kennedy GT, Dunsby C, Magee AI, Courtney P, Katan M, Neil MAA, French PMWet al., 2007, High speed optically sectioned fluorescence lifetime imaging permits study of live cell signaling events, Optics Express, Vol: 15, Pages: 16656-16673

We present a time domain optically sectioned fluorescence lifetime imaging (FLIM) microscope developed for high-speed live cell imaging. This single photon excited system combines wide field parallel pixel detection with confocal sectioning utilizing spinning Nipkow disc microscopy. It can acquire fluorescence lifetime images of live cells at up to 10 frames per second (fps), permitting high-speed FLIM of cell dynamics and protein interactions with potential for high throughput cell imaging and screening applications. We demonstrate the application of this FLIM microscope to real-time monitoring of changes in lipid order in cell membranes following cholesterol depletion using cyclodextrin and to the activation of the small GTP-ase Ras in live cells using FRET. © 2007 Optical Society of America.

Journal article

Grant DM, McGinty J, McGhee EJ, Bunney TD, Owen DM, Talbot CB, Zhang W, Kumar S, Munro I, Lanigan PMP, Kennedy GT, Dunsby C, Magee AI, Courtney P, Katan M, Neil MAA, French PMWet al., 2007, High speed optically sectioned fluorescence lifetime imaging permits study of live cell signaling events, OPTICS EXPRESS, Vol: 15, Pages: 15656-15673, ISSN: 1094-4087

Journal article

Soloviev VY, Tahir KB, McGinty J, Elson DS, Neil MAA, French PMW, Arridge SRet al., 2007, Fluorescence lifetime imaging by using time-gated data acquisition, APPLIED OPTICS, Vol: 46, Pages: 7384-7391, ISSN: 1559-128X

Journal article

Soloviev VY, McGinty J, Tahir KB, Neil MAA, Sardini A, Hajnal JV, Arridge SR, French PMWet al., 2007, Fluorescence lifetime tomography of live cells expressing enhanced green fluorescent protein embedded in a scattering medium exhibiting background autofluorescence, OPTICS LETTERS, Vol: 32, Pages: 2034-2036, ISSN: 0146-9592

Journal article

Soloviev VY, Tahir KB, McGinty J, Elson DS, Neil M, Sardini A, Hajnal J, Arridge SR, French PMWet al., 2007, Fluorescence lifetime imaging through turbid media reconstructed in the Fourier domain using time-gated imaging data, European Conference on Biomedical Optics, Publisher: SPIE

Conference paper

De Beule P, Owen DM, Manning HB, Talbot CB, Requejo-Isidro J, Dunsby C, McGinty J, Benninger RKP, Elson DS, Munro I, Lever MJ, Anand P, Neil MAA, French PMWet al., 2007, Rapid hyperspectral fluorescence lifetime imaging, MICROSCOPY RESEARCH AND TECHNIQUE, Vol: 70, Pages: 481-484, ISSN: 1059-910X

Journal article

Owen DM, Manning HB, de Beule P, Talbot C, Requejo-Isidro J, Dunsby C, McGinty J, Benninger RKP, Elson DS, Munro I, Galletly NP, Lever MJ, Stamp GW, Anand P, Neil MAA, French PMWet al., 2007, Development of a hyperspectral fluorescence lifetime imaging microscope and its application to tissue imaging, Conference on Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues V, Publisher: SPIE-INT SOC OPTICAL ENGINEERING, ISSN: 0277-786X

Conference paper

Soloviev VY, Tahir KB, McGinty J, Elson DS, Neil M, Sardini A, Hajnal J, Arridge SR, French PMWet al., 2007, Fluorescence lifetime imaging through turbid media reconstructed in the Fourier domain using time-gated imaging data, Conference on Diffuse Optical Imaging of Tissue, Publisher: SPIE-INT SOC OPTICAL ENGINEERING, ISSN: 0277-786X

Conference paper

Owen D M, Manning H B, de Beule P, Talbot C B, Requejo-Isidro J, Dunsby C W, McGinty J A, Benninger, R K P, Elson D S, Munro I H, Galletly N P, Lever J, Stamp G W, Anand P, Neil, M A A, French, P M Wet al., 2007, Rapid hyperspectral fluorescence lifetime imaging, IMAGING, MANIPULATION AND ANALYSIS OF BIOMOLECULES, CELLS, AND TISSUES V, BIOS, Publisher: SPIE

Conference paper

Lekadir, Karim, Elson, Daniel S, Requejo-Isidro, Jose, Dunsby, Christopher, McGinty, James, Galletly, Neil, Stamp, Gordon, French, Paul MW, Yang, Guang-Zhonget al., 2006, Tissue Characterization using Dimensionality Reduction and Fluorescence Imaging, Medical Image Computing and Computer Assisted Intervention, Publisher: Medical Image Computing and Computer Assisted Intervention

Conference paper

Galletly N, McGinty J, Munro I, Elson DS, Requejo-Isidro J, Dunsby C, Neil MA, Thillainayagam AV, French PM, Stamp GWet al., 2006, Fluorescence lifetime imaging of liver cancer, Digestive Disease Week Meeting/107th Annual Meeting of the American-Gastroenterlogical-Association, Publisher: W B SAUNDERS CO-ELSEVIER INC, Pages: A791-A791, ISSN: 0016-5085

Conference paper

Lanigan PMP, Dunsby C, McGinty J, Elson DS, Requejo-Isidro J, Munro I, Galletly N, Treanor B, Önfelt B, McCann F, Davis DM, Neil MAA, French PMWet al., 2006, An electronically tunable ultrafast laser source applied to fluorescence imaging and fluorescence lifetime imaging microscopy

We demonstrate that spectral selection from a supercontinuum generated in a microstructured fibre can provide a continuously electronically tunable ultrafast spatially coherent source for confocal microscopy and both scanning and wide field fluorescence lifetime imaging. © 2005 Optical Society of America.

Conference paper

Lekadir K, Elson DS, Requejo-Isidro J, Dunsby C, McGinty J, Galletly N, Stamp G, French PMW, Yang G-Zet al., 2006, Tissue characterization using dimensionality reduction and fluorescence imaging, MEDICAL IMAGE COMPUTING AND COMPUTER-ASSISTED INTERVENTION - MICCAI 2006, PT 2, Vol: 4191, Pages: 586-593, ISSN: 0302-9743

Journal article

Dunsby C, Lanigan PMP, McGinty J, De Beule PAA, Auksorius E, Schimpf DN, Elson DS, Requejo-Isidro J, Munro I, Galletly N, Treanor B, Önfelt B, McCann F, Davis DM, Neil MAA, French PMWet al., 2005, An electronically tunable ultrafast laser source applied to fluorescence imaging and microscopy including fluorescence lifetime imaging

Conference paper

Lanigan PMP, Dunsby C, McGinty J, Elson DS, Requejo-Isidro J, Munro I, Galletly N, Treanor B, Önfelt B, McCann F, Davis DM, Neil MAA, French PMWet al., 2005, An electronically tunable ultrafast laser source applied to fluorescence imaging and fluorescence lifetime imaging microscopy, Pages: 1366-1368

We demonstrate that spectral selection from a supercontinuum generated in a microstructured fibre can provide a continuously electronically tunable ultrafast spatially coherent source for confocal microscopy and both scanning and wide field fluorescence lifetime imaging. © 2005 Optical Society of America.

Conference paper

Munro I, McGinty J, Galletly N, Requejo-Isidro J, Lanigan PMP, Elson DS, Dunsby C, Neil MAA, Lever MJ, Stamp GWH, French PMWet al., 2005, Toward the clinical application of time-domain fluorescence lifetime imaging, JOURNAL OF BIOMEDICAL OPTICS, Vol: 10, ISSN: 1083-3668

Journal article

Benninger RKP, Hofmann O, McGinty J, Requejo-Isidro J, Munro I, Neil MAA, deMello AJ, French PMWet al., 2005, Time-resolved fluorescence imaging of solvent interactions in microfluidic devices, OPTICS EXPRESS, Vol: 13, Pages: 6275-6285, ISSN: 1094-4087

Journal article

Benninger RKP, McGinty J, Hofmann O, Requejo-Isidro J, Munro I, Elson DS, Dunsby CW, Onfelt B, Davis DM, Neil MAA, de Mello AJ, French PMWet al., 2005, Application of multi-dimensional fluorescence imaging to microfluidic devices, European Conference on Lasers and Electro-Optics

Conference paper

Lanigan PMP, Dunsby C, McGinty J, Elson DS, Requejo-Isidro J, Munro I, Galletly N, Treanor B, Onfelt B, McCann F, Davis DM, Neil MAA, French PMWet al., 2005, An electronically tunable ultrafast laser source applied to fluorescence imaging and fluorescence lifetime imaging microscopy, Washington, CONFERENCE ON LASERS & ELECTRO-OPTICS (CLEO), Publisher: Optical Society of America, Pages: 1366-1368

Conference paper

Benninger RKP, Hofmann O, McGinty J, Requejo-Isidro J, Munro I, Neil MAA, DeMello AJ, French PMWet al., 2005, 3D high-speed time-resolved fluorescence imaging of solvent interactions in microfluidic devices, Pages: 16-18

This paper reports on the application of novel wide-field time-resolved fluorescence imaging methods to monitor solvent interactions and mixing in microfluidic devices. Time-resolved fluorescence anisotropy imaging (TR-FAIM) is employed for 3D viscosity mapping with sub-micron resolution. To image dynamic fluid mixing in real-time, we demonstrate high-speed fluorescence lifetime imaging (FLIM) at video acquisition rates. Copyright © 2005 by the Transducer Research Foundation, Inc.

Conference paper

McGinty J, Munro I, Requejo-Isidro J, Elson DS, Dunsby C, Neil MAA, French PMW, Galletly NP, Stamp GWHet al., 2005, Video rate fluorescence lifetime imaging and fluorescence lifetime endoscopy (Article no.586408), Proceedings- Spie the International Society for Optical Engineering, Vol: 5864, ISSN: 0277-786X

Journal article

McGinty J, Munro I, Requejo-Isidro J, Elson DS, Dunsby C, Neil MAA, French PMW, Galletly NP, Stamp GWHet al., 2005, Video rate fluorescence lifetime imaging and fluorescence lifetime endoscopy (Article no.586408), Proceedings- Spie the International Society for Optical Engineering, Vol: 5864, ISSN: 0277-786X

Journal article

McGinty J, Munro I, Requejo-Isidro J, Elson DS, Dunsby C, Neil MAA, French PMW, Galletly NP, Stamp GWHet al., 2005, Video rate fluorescence lifetime imaging and fluorescence lifetime endoscopy (Article no.586408), ISSN: 0277-786X

Conference paper

Dunsby C, Lanigan PMP, McGinty J, Elson DS, Requejo-Isidro J, Munro I, Galletly N, McCann F, Treanor B, Onfelt B, Davis DM, Neil MAA, French PMWet al., 2004, An electronically tunable ultrafast laser source applied to fluorescence imaging and fluorescence lifetime imaging microscopy, JOURNAL OF PHYSICS D-APPLIED PHYSICS, Vol: 37, Pages: 3296-3303, ISSN: 0022-3727

Journal article

Elson DS, Munro I, Requejo-Isidro J, McGinty J, Dunsby C, Galletly N, Stamp GW, Neil MAA, Lever MJ, Kellett PA, Dymoke-Bradshaw A, Hares J, French PMWet al., 2004, Real-time time-domain fluorescence lifetime imaging including single-shot acquisition with a segmented optical image intensifier, NEW JOURNAL OF PHYSICS, Vol: 6, ISSN: 1367-2630

Journal article

Requejo-Isidro J, McGinty J, Munro I, Elson DS, Galletly NP, Lever MJ, Neil MAA, Stamp GWH, French PMW, Kellett PA, Hares JD, Dymoke-Bradshaw AKLet al., 2004, High-speed wide-field time-gated endoscopic fluorescence-lifetime imaging, OPTICS LETTERS, Vol: 29, Pages: 2249-2251, ISSN: 0146-9592

Journal article

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