Imperial College London


Faculty of Natural SciencesDepartment of Physics

Senior Lecturer



+44 (0)20 7594 7719james.mcginty




621Blackett LaboratorySouth Kensington Campus






BibTex format

author = {Van, de Pette M and Abbas, A and Feytout, A and McNamara, G and Bruno, L and To, WK and Dimond, A and Sardini, A and Webster, Z and McGinty, J and Paul, EJ and Ungless, MA and French, PMW and Withers, DJ and Uren, A and Ferguson-Smith, AC and Merkenschlager, M and John, RM and Fisher, AG},
doi = {10.1016/j.celrep.2017.01.010},
journal = {Cell Reports},
pages = {1090--1099},
title = {Visualizing changes in Cdkn1c expression links early life adversity to imprint mis-regulation in adults},
url = {},
volume = {31},
year = {2017}

RIS format (EndNote, RefMan)

AB - Imprinted genes are regulated according to parental origin and can influence embryonic growth and metabolism and confer disease susceptibility.Here we designed sensitive allele-specific reporters to non-invasively monitor imprinted Cdkn1cexpression in mice and showed that expression was modulated by environmental factors encounteredin utero.Acute exposure to chromatin modifyingdrugs resulted in de-repression of paternally inherited (silent) Cdkn1calleles in embryos that was temporary and resolved after birth.In contrast, deprivation of maternal dietary proteinin uteroprovoked permanent de-repression of imprinted Cdkn1cexpression that was sustained into adulthood and occurred through a folate-dependent mechanism of DNA methylation loss.Given the function of imprinted genes in regulating behavior and metabolic processes in adults, these results establish imprinting deregulation as a credible mechanism linking early life adversity to later-life outcomes.Furthermore,Cdkn1c-luciferasemice offer non-invasivetools to identify factors that disrupt epigenetic processes and strategies to limit their long-term impact.
AU - Van,de Pette M
AU - Abbas,A
AU - Feytout,A
AU - McNamara,G
AU - Bruno,L
AU - To,WK
AU - Dimond,A
AU - Sardini,A
AU - Webster,Z
AU - McGinty,J
AU - Paul,EJ
AU - Ungless,MA
AU - French,PMW
AU - Withers,DJ
AU - Uren,A
AU - Ferguson-Smith,AC
AU - Merkenschlager,M
AU - John,RM
AU - Fisher,AG
DO - 10.1016/j.celrep.2017.01.010
EP - 1099
PY - 2017///
SN - 2211-1247
SP - 1090
TI - Visualizing changes in Cdkn1c expression links early life adversity to imprint mis-regulation in adults
T2 - Cell Reports
UR -
UR -
VL - 31
ER -