Imperial College London
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ProfessorJamesMoore Jr

Faculty of Engineering, Department of Bioengineering

The Bagrit & RAEng Chair in Medical Device Design
 
 
 
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Contact

 

+44 (0)20 7594 9795james.moore.jr CV

 
 
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Location

 

414Royal School of MinesSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Jamalian:2017:10.1038/s41598-017-11599-x,
author = {Jamalian, S and Jafarnejad, M and Zawieja, SD and Bertram, CD and Gashev, AA and Zawieja, DC and Davis, MJ and Moore, JE},
doi = {10.1038/s41598-017-11599-x},
journal = {Scientific Reports},
pages = {1--17},
title = {Demonstration and analysis of the suction effect for pumping lymph from tissue beds at subatmospheric pressure},
url = {http://dx.doi.org/10.1038/s41598-017-11599-x},
volume = {7},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Many tissues exhibit subatmospheric interstitial pressures under normal physiologic conditions. The mechanisms by which the lymphatic system extracts fluid from these tissues against the overall pressure gradient are unknown. We address this important physiologic issue by combining experimental measurements of contractile function and pressure generation with a previously validated mathematical model. We provide definitive evidence for the existence of ‘suction pressure’ in collecting lymphatic vessels, which manifests as a transient drop in pressure downstream of the inlet valve following contraction. This suction opens the inlet valve and is required for filling in the presence of low upstream pressure. Positive transmural pressure is required for this suction, providing the energy required to reopen the vessel. Alternatively, external vessel tethering can serve the same purpose when the transmural pressure is negative. Suction is transmitted upstream, allowing fluid to be drawn in through initial lymphatics. Because suction plays a major role in fluid entry to the lymphatics and is affected by interstitial pressure, our results introduce the phenomenon as another important factor to consider in the study of lymphoedema and its treatment.
AU  - Jamalian,S
AU  - Jafarnejad,M
AU  - Zawieja,SD
AU  - Bertram,CD
AU  - Gashev,AA
AU  - Zawieja,DC
AU  - Davis,MJ
AU  - Moore,JE
DO  - 10.1038/s41598-017-11599-x
EP  - 17
PY  - 2017///
SN  - 2045-2322
SP  - 1
TI  - Demonstration and analysis of the suction effect for pumping lymph from tissue beds at subatmospheric pressure
T2  - Scientific Reports
UR  - http://dx.doi.org/10.1038/s41598-017-11599-x
UR  - https://www.nature.com/articles/s41598-017-11599-x
VL  - 7
ER  -
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