Imperial College London
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ProfessorJamesMoore Jr

Faculty of Engineering, Department of Bioengineering

The Bagrit & RAEng Chair in Medical Device Design
 
 
 
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Contact

 

+44 (0)20 7594 9795james.moore.jr CV

 
 
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Location

 

414Royal School of MinesSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Johnson:2020:10.1371/journal.pone.0230092,
author = {Johnson, SC and Chakraborty, S and Drosou, A and Cunnea, P and Tzovaras, D and Nixon, K and Zawieja, DC and Muthuchamy, M and Fotopoulou, C and Moore, JE},
doi = {10.1371/journal.pone.0230092},
journal = {PLoS One},
pages = {1--23},
title = {Inflammatory state of lymphatic vessels and miRNA profiles associated with relapse in ovarian cancer patients},
url = {http://dx.doi.org/10.1371/journal.pone.0230092},
volume = {15},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Lymphogenic spread is associated with poor prognosis in epithelial ovarian cancer (EOC), yet little is known regarding roles of non-peri-tumoural lymphatic vessels (LVs) outside the tumour microenvironment that may impact relapse. The aim of this feasibility study was to assess whether inflammatory status of the LVs and/or changes in the miRNA profile of the LVs have potential prognostic and predictive value for overall outcome and risk of relapse. Samples of macroscopically normal human lymph LVs (n = 10) were isolated from the external iliac vessels draining the pelvic region of patients undergoing debulking surgery. This was followed by quantification of the inflammatory state (low, medium and high) and presence of cancer-infiltration of each LV using immunohistochemistry. LV miRNA expression profiling was also performed, and analysed in the context of high versus low inflammation, and cancer-infiltrated versus non-cancer-infiltrated. Results were correlated with clinical outcome data including relapse with an average follow-up time of 13.3 months. The presence of a high degree of inflammation correlated significantly with patient relapse (p = 0.033). Cancer-infiltrated LVs showed a moderate but non-significant association with relapse (p = 0.07). Differential miRNA profiles were identified in cancer-infiltrated LVs and those with high versus low inflammation. In particular, several members of the let-7 family were consistently down-regulated in highly inflamed LVs (>1.8-fold, p<0.05) compared to the less inflamed ones. Down-regulation of the let-7 family appears to be associated with inflammation, but whether inflammation contributes to or is an effect of cancer-infiltration requires further investigation.
AU  - Johnson,SC
AU  - Chakraborty,S
AU  - Drosou,A
AU  - Cunnea,P
AU  - Tzovaras,D
AU  - Nixon,K
AU  - Zawieja,DC
AU  - Muthuchamy,M
AU  - Fotopoulou,C
AU  - Moore,JE
DO  - 10.1371/journal.pone.0230092
EP  - 23
PY  - 2020///
SN  - 1932-6203
SP  - 1
TI  - Inflammatory state of lymphatic vessels and miRNA profiles associated with relapse in ovarian cancer patients
T2  - PLoS One
UR  - http://dx.doi.org/10.1371/journal.pone.0230092
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000556674500032&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0230092
UR  - http://hdl.handle.net/10044/1/86473
VL  - 15
ER  -
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