Imperial College London
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Professor James Seddon

Faculty of Medicine, Department of Infectious Disease

Professor of Global Child Health
 
 
 
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Contact

 

+44 (0)20 7594 3179james.seddon

 
 
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Location

 

235Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Channon-Wells:2023:10.1016/s2665-9913(23)00029-2,
author = {Channon-Wells, S and Vito, O and McArdle, AJ and Seaby, EG and Patel, H and Shah, P and Pazukhina, E and Wilson, C and Broderick, C and D'Souza, G and Keren, I and Nijman, RG and Tremoulet, A and Munblit, D and Ulloa-Gutierrez, R and Carter, MJ and Ramnarayan, P and De, T and Hoggart, C and Whittaker, E and Herberg, JA and Kaforou, M and Cunnington, AJ and Blyuss, O and Levin, M and Chouli, M and Hamadouche, N and Ladj, MS and Agrimbau, Vázquez J and Carmona, R and Collia, AG and Ellis, A and Natta, D and Pérez, L and Rubiños, M and Veliz, N and Yori, S and Britton, PN and Burgner, DP and Carey, E and Crawford, NW and Giuliano, H and McMinn, A and Wong, S and Wood, N and Holter, W and Krainz, M and Ulreich, R and Zurl, C and Dehoorne, J and Haerynck, F and Hoste, L and Schelstraete, P and Vandekerckhove, K and Willems, J and Almeida, Farias CG and Almeida, FJ and Alves, Leal I and Araujo, da Silva AR and Araujo, e Silva AE and Barreiro, STA and Bomfim, Prado da Silva DG and Cervi, MC a},
doi = {10.1016/s2665-9913(23)00029-2},
journal = {The Lancet Rheumatology},
pages = {e184--e199},
title = {Immunoglobulin, glucocorticoid, or combination therapy for multisystem inflammatory syndrome in children: a propensity-weighted cohort study},
url = {http://dx.doi.org/10.1016/s2665-9913(23)00029-2},
volume = {5},
year = {2023}
}
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TY  - JOUR
AB  - BackgroundMultisystem inflammatory syndrome in children (MIS-C), a hyperinflammatory condition associated with SARS-CoV-2 infection, has emerged as a serious illness in children worldwide. Immunoglobulin or glucocorticoids, or both, are currently recommended treatments.MethodsThe Best Available Treatment Study evaluated immunomodulatory treatments for MIS-C in an international observational cohort. Analysis of the first 614 patients was previously reported. In this propensity-weighted cohort study, clinical and outcome data from children with suspected or proven MIS-C were collected onto a web-based Research Electronic Data Capture database. After excluding neonates and incomplete or duplicate records, inverse probability weighting was used to compare primary treatments with intravenous immunoglobulin, intravenous immunoglobulin plus glucocorticoids, or glucocorticoids alone, using intravenous immunoglobulin as the reference treatment. Primary outcomes were a composite of inotropic or ventilator support from the second day after treatment initiation, or death, and time to improvement on an ordinal clinical severity scale. Secondary outcomes included treatment escalation, clinical deterioration, fever, and coronary artery aneurysm occurrence and resolution. This study is registered with the ISRCTN registry, ISRCTN69546370.FindingsWe enrolled 2101 children (aged 0 months to 19 years) with clinically diagnosed MIS-C from 39 countries between June 14, 2020, and April 25, 2022, and, following exclusions, 2009 patients were included for analysis (median age 8·0 years [IQR 4·2–11·4], 1191 [59·3%] male and 818 [40·7%] female, and 825 [41·1%] White). 680 (33·8%) patients received primary treatment with intravenous immunoglobulin, 698 (34·7%) with intravenous immunoglobulin plus glucocorticoids, 487 (24·2%) with glucocorticoids alone; 59 (2·9%) patients received other combinations, including biologica
AU  - Channon-Wells,S
AU  - Vito,O
AU  - McArdle,AJ
AU  - Seaby,EG
AU  - Patel,H
AU  - Shah,P
AU  - Pazukhina,E
AU  - Wilson,C
AU  - Broderick,C
AU  - D'Souza,G
AU  - Keren,I
AU  - Nijman,RG
AU  - Tremoulet,A
AU  - Munblit,D
AU  - Ulloa-Gutierrez,R
AU  - Carter,MJ
AU  - Ramnarayan,P
AU  - De,T
AU  - Hoggart,C
AU  - Whittaker,E
AU  - Herberg,JA
AU  - Kaforou,M
AU  - Cunnington,AJ
AU  - Blyuss,O
AU  - Levin,M
AU  - Chouli,M
AU  - Hamadouche,N
AU  - Ladj,MS
AU  - Agrimbau,Vázquez J
AU  - Carmona,R
AU  - Collia,AG
AU  - Ellis,A
AU  - Natta,D
AU  - Pérez,L
AU  - Rubiños,M
AU  - Veliz,N
AU  - Yori,S
AU  - Britton,PN
AU  - Burgner,DP
AU  - Carey,E
AU  - Crawford,NW
AU  - Giuliano,H
AU  - McMinn,A
AU  - Wong,S
AU  - Wood,N
AU  - Holter,W
AU  - Krainz,M
AU  - Ulreich,R
AU  - Zurl,C
AU  - Dehoorne,J
AU  - Haerynck,F
AU  - Hoste,L
AU  - Schelstraete,P
AU  - Vandekerckhove,K
AU  - Willems,J
AU  - Almeida,Farias CG
AU  - Almeida,FJ
AU  - Alves,Leal I
AU  - Araujo,da Silva AR
AU  - Araujo,e Silva AE
AU  - Barreiro,STA
AU  - Bomfim,Prado da Silva DG
AU  - Cervi,MC
AU  - dos,Santos Naja Cardoso MV
AU  - Henriques,Teixeira C
AU  - Jarovsky,D
AU  - Martins,Araujo J
AU  - Naaman,Berezin E
AU  - Palazzi,Sáfadi MA
AU  - Paternina-de,la Ossa RA
AU  - Souza,Vieira C
AU  - Dimitrova,A
AU  - Ganeva,M
AU  - Stefanov,S
AU  - Telcharova-Mihaylovska,A
AU  - Biggs,CM
AU  - Lopez,A
AU  - Scuccimarri,R
AU  - Tan,R
AU  - Wasserman,S
AU  - Withington,D
AU  - Ampuero,C
AU  - Aravena,J
AU  - Bustos,B R
AU  - Casanova,D
AU  - Cruces,P
AU  - Diaz,F
AU  - García-Salum,T
AU  - Godoy,L
AU  - Medina,RA
AU  - Valenzuela,Galaz G
AU  - Camacho-Moreno,G
AU  - Avila-Aguero,ML
AU  - Brenes-Chacón,H
AU  - Camacho-Badilla,K
AU  - Ivankovich-Escoto,G
AU  - Naranjo-Zuniga,G
AU  - Soriano-Fallas,A
AU  - Ulloa-Gutierrez,R
AU  - Yock-Corrales,A
AU  - Amer,MA
AU  - Abdelmeguid,Y
AU  - Ahmed,YHHZ
AU  - Badib,A
AU  - Badreldin,K
AU  - Elkhashab,Y
AU  - Heshmat,H
AU  - Hussein,A
AU  - Mohamed,Hussein AH
AU  - Ibrahim,S
AU  - Shoman,W
AU  - Yakout,RM
AU  - Heinonen,S
AU  - Angoulvant,F
AU  - Belot,A
AU  - Ouldali,N
AU  - Beske,F
AU  - Heep,A
AU  - Masjosthusmann,K
AU  - Reiter,K
AU  - van,den Heuvel I
AU  - von,Both U
AU  - Agrafiotou,A
AU  - Antachopoulos,C
AU  - Charisi,K
AU  - Eleftheriou,I
AU  - Farmaki,E
AU  - Fotis,L
AU  - Kafetzis,D
AU  - Koletsi,P
AU  - Kourtesi,K
AU  - Lampidi,S
AU  - Liakopoulou,T
AU  - Maritsi,D
AU  - Michailidou,E
AU  - Milioudi,M
AU  - Mparmpounaki,I
AU  - Papadimitriou,E
AU  - Papaevangelou,V
AU  - Roilides,E
AU  - Tsiatsiou,O
AU  - Tsolas,G
AU  - Tsolia,M
AU  - Vantsi,P
AU  - Banegas,Pineda LY
AU  - Borjas,Aguilar KL
AU  - Cantillano,Quintero EM
AU  - Ip,P
AU  - Kwan,MYW
AU  - Kwok,J
AU  - Lau,YL
AU  - To,K
AU  - Wong,JSC
AU  - David,M
AU  - Farkas,D
AU  - Ka
DO  - 10.1016/s2665-9913(23)00029-2
EP  - 199
PY  - 2023///
SN  - 2665-9913
SP  - 184
TI  - Immunoglobulin, glucocorticoid, or combination therapy for multisystem inflammatory syndrome in children: a propensity-weighted cohort study
T2  - The Lancet Rheumatology
UR  - http://dx.doi.org/10.1016/s2665-9913(23)00029-2
UR  - https://www.sciencedirect.com/science/article/pii/S2665991323000292?via%3Dihub
UR  - http://hdl.handle.net/10044/1/103171
VL  - 5
ER  -
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