Imperial College London

Jeff Eaton

Faculty of MedicineSchool of Public Health

Senior Lecturer in HIV Epidemiology







Norfolk PlaceSt Mary's Campus






BibTex format

author = {Woods, B and Rothery, C and Anderson, S-J and Eaton, JW and Revill, P and Hallett, TB and Claxton, K},
journal = {BMJ Global Health},
title = {Appraising the value of evidence generation activities: An HIV Modelling Study},
url = {},

RIS format (EndNote, RefMan)

AB - Introduction: The generation of robust evidence has been emphasised as a priority for global health. Evidence generation spansa wide range of activities including clinical trials, surveillance programmes, andhealth systemperformance measurement. As resources for health care and research are limited, the desirability of research expenditure should be assessed on the same basis as other health care resources, i.e. the health gains from researchmust be expected to exceed the health opportunity costs imposed as funds are diverted to research rather than service provision. Methods: We developed atransmission and costing model to examine the impact of generating additional evidence to reduce uncertaintieson the evolution of ageneralised HIV epidemic in Zambia.Results: We demonstrate three important points. Firstly, we can quantify the value of additional evidence in terms of the health gain it is expected to generate. Secondly, we can quantify the health opportunity cost imposedby research expenditure. Thirdly, the value of evidence generation depends on thebudgetarypolicies in placefor managingHIV resourcesunder uncertainty. Generating evidence to reduce uncertainty is particularly valuablewhen decisionmakers are requiredto strictly adhereto expenditure plansand when transfers of funds across geographies/programmesare restricted.Conclusion: Better evidence can lead to health improvementsin the same way as direct delivery of health care. Quantitative appraisals of evidence generation activities are importantand should reflect the impact of improved evidence onpopulation health, evidence generationcosts, and budgetary policiesin place.
AU - Woods,B
AU - Rothery,C
AU - Anderson,S-J
AU - Eaton,JW
AU - Revill,P
AU - Hallett,TB
AU - Claxton,K
SN - 2059-7908
TI - Appraising the value of evidence generation activities: An HIV Modelling Study
T2 - BMJ Global Health
UR -
ER -