Imperial College London

DrJerryHeng

Faculty of EngineeringDepartment of Chemical Engineering

Reader in Particle Technology
 
 
 
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Contact

 

+44 (0)20 7594 0784jerry.heng

 
 
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Location

 

417AACE ExtensionSouth Kensington Campus

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Summary

 

Publications

Publication Type
Year
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122 results found

Shah UV, Olusanmi D, Narang AS, Hussain MA, Tobyn MJ, Hinder SJ, Heng JYYet al., 2015, Decoupling the Contribution of Surface Energy and Surface Area on the Cohesion of Pharmaceutical Powders, Pharmaceutical Research, Vol: 32, Pages: 248-259, ISSN: 1573-904X

PurposeSurface area and surface energy of pharmaceutical powders are affected by milling and may influence formulation, performance and handling. This study aims to decouple the contribution of surface area and surface energy, and to quantify each of these factors, on cohesion.MethodsMefenamic acid was processed by cryogenic milling. Surface energy heterogeneity was determined using a Surface Energy Analyser (SEA) and cohesion measured using a uniaxial compression test. To decouple the surface area and surface energy contributions, milled mefenamic acid was “normalised” by silanisation with methyl groups, confirmed using X-ray Photoelectron Spectroscopy.ResultsBoth dispersive and acid–base surface energies were found to increase with increasing milling time. Cohesion was also found to increase with increasing milling time. Silanised mefenamic acid possessed a homogenous surface with a surface energy of 33.1 ± 1.4 mJ/m2 , for all milled samples. The cohesion for silanised mefenamic acid was greatly reduced, and the difference in the cohesion can be attributed solely to the increase in surface area. For mefenamic acid, the contribution from surface energy and surface area on cohesion was quantified to be 57% and 43%, respectively.ConclusionsHere, we report an approach for decoupling and quantifying the contribution from surface area and surface energy on powder cohesion.

Journal article

Wang D, Da Z, Zhang B, Isbell MA, Dong Y, Zhou X, Liu H, Heng JYY, Yang Zet al., 2015, Stability study of tubular DNA origami in the presence of protein crystallisation buffer, RSC ADVANCES, Vol: 5, Pages: 58734-58737, ISSN: 2046-2069

Journal article

Parambil JV, Poornachary SK, Hinder SJ, Tan RBH, Heng JYYet al., 2015, Establishing template-induced polymorphic domains for API crystallisation: the case of carbamazepine, CRYSTENGCOMM, Vol: 17, Pages: 6384-6392, ISSN: 1466-8033

Journal article

Heng J, 2015, Preface, ISBN: 9783319202051

Book

Hedberg S, Heng JYY, Williams DR, Liddell Jet al., 2015, Chromatographic tools to predict the stability of mAbs for faster identification of therapeutic candidates, Pages: 1150-1151

© Copyright American Institute of Chemical Engineers. All rights reserved. Protein-protein molecular interactions are known to be involved in protein solution aggregation behaviour and are a common issue for the manufacturing of therapeutic proteins such as mAbs. Much effort has been employed to gain a better understanding of aggregation, however the mechanisms leading to protein aggregation are still not fully understood. The osmotic second virial coefficient (B22) is a fundamental physiochemical property that describes protein-protein interactions solution, which can be a useful tool to predict aggregation propensity of proteins. One way of predicting aggregation propensity is self-interaction chromatography (SIC), which recently have shown to be a promising tool for better understanding of phase behaviour of proteins. Another technique, cross-interaction chromatography (CIC), has shown to be an even more high-throughput technique than its predecessor with possibly the same capabilities. This work consists of two experimental studies with therapeutic mAbs to improve SIC and CIC as a tool to predict protein aggregation. The first part includes a 10 times scale-down study of therapeutic mAbs from laboratory scale macro-columns to micro-scale columns, which will enable the determination of B22 for the individual protein as well as the cross-virial coefficient, B23, between two proteins. Micro SIC and CIC uses only a few milligrams of mAb in order to obtain a complete formulation study. The results from the first part of the study proved to give good comparable results between the micro and macro scales enabling the use of micro SIC for B22 determinations. The second part of this work presents an extensive formulation study of mAbs, varying pH and salt, as well as the presence of different stabilisers as well as different external factors known to induce aggregation. The B22 and B23 values determined from the formulation study are then correlated with aggregation

Conference paper

Lee K-Y, Blaker JJ, Heng JYY, Murakami R, Bismarck Aet al., 2014, pH-triggered phase inversion and separation of hydrophobised bacterial cellulose stabilised Pickering emulsions, REACTIVE & FUNCTIONAL POLYMERS, Vol: 85, Pages: 208-213, ISSN: 1381-5148

Journal article

Spathi C, Young N, Heng JYY, Vandeperre LJM, Cheeseman CRet al., 2014, A simple method for preparing super-hydrophobic powder from paper sludge ash, Materials Letters, Vol: 142, Pages: 80-83, ISSN: 1873-4979

Paper sludge ash (PSA) is a readily available waste material generated by the paper recycling industry. This work reports on the production of hydrophobic powders by dry milling PSA in the presence of a fatty acid surface functionalising agent. Optimum laboratory processing involves dry milling for 8 h with a 4 wt.% addition of stearic acid and this produced a super-hydrophobic powder with a water contact angle of 153°. Different chain length fatty acids were investigated but stearic acid produced the highest hydrophobicity. The super-hydrophobicity of PSA results from the micro-particulate texture induced by dry milling with simultaneous formation of calcium stearate self-assembling surface monolayers chemically bonded to fracture surfaces.

Journal article

Shah UV, Olusanmi D, Narang AS, Hussain MA, Tobyn MJ, Heng JYYet al., 2014, Decoupling the contribution of dispersive and acid-base components of surface energy on the cohesion of pharmaceutical powders, International Journal of Pharmaceutics, Vol: 475, Pages: 592-596, ISSN: 1873-3476

This study reports an experimental approach to determine the contribution from two different components of surface energy on cohesion. A method to tailor the surface chemistry of mefenamic acid via silanization is established and the role of surface energy on cohesion is investigated. Silanization was used as a method to functionalize mefenamic acid surfaces with four different functional end groups resulting in an ascending order of the dispersive component of surface energy. Furthermore, four haloalkane functional end groups were grafted on to the surface of mefenamic acid, resulting in varying levels of acid-base component of surface energy, while maintaining constant dispersive component of surface energy. A proportional increase in cohesion was observed with increases in both dispersive as well as acid-base components of surface energy. Contributions from dispersive and acid-base surface energy on cohesion were determined using an iterative approach. Due to the contribution from acid-base surface energy, cohesion was found to increase ∼11.7× compared to the contribution from dispersive surface energy. Here, we provide an approach to deconvolute the contribution from two different components of surface energy on cohesion, which has the potential of predicting powder flow behavior and ultimately controlling powder cohesion.

Journal article

Johari K, Saman N, Song ST, Heng JYY, Mat Het al., 2014, Study of Hg( II) Removal From Aqueous Solution Using Lignocellulosic Coconut Fiber Biosorbents: Equilibrium and Kinetic Evaluation, CHEMICAL ENGINEERING COMMUNICATIONS, Vol: 201, Pages: 1198-1220, ISSN: 0098-6445

Journal article

Cole K, Buffler A, Cilliers JJ, Govender I, Heng JYY, Liu C, Parker DJ, Shah UV, van Heerden M, Fan Xet al., 2014, A surface coating method to modify tracers for positron emission particle tracking (PEPT) measurements of froth flotation, POWDER TECHNOLOGY, Vol: 263, Pages: 26-30, ISSN: 0032-5910

Journal article

Puncochova K, Heng JYY, Beranek J, Stepanek Fet al., 2014, Investigation of drug-polymer interaction in solid dispersions by vapour sorption methods, INTERNATIONAL JOURNAL OF PHARMACEUTICS, Vol: 469, Pages: 159-167, ISSN: 0378-5173

Journal article

Smith RR, Williams DR, Burnett DJ, Heng JYYet al., 2014, A New Method To Determine Dispersive Surface Energy Site Distributions by Inverse Gas Chromatography, Langmuir, Vol: 30, Pages: 8029-8035, ISSN: 1520-5827

A computational model to predict the relative energy site contributions of a heterogeneous material from data collected by finite dilution–inverse gas chromatography (FD-IGC) is presented in this work. The methodology employed a multisolvent system site filling model utilizing Boltzmann statistics, expanding on previous efforts to calculate “experienced energies” at varying coverage, yielding a retention volume distribution allowing calculation of a surface free energy distribution. Surface free energy distributions were experimentally measured for racemic ibuprofen and β-mannitol powders, the energies of each were found in the ranges 43–52 and 40–55 mJ/m2, respectively, over a surface coverage range of 0–8%. The computed contributions to surface energy values were found to match closely with data collected on macroscopic crystals by alternative techniques (±<1.5 mJ/m2).

Journal article

Shah UV, Olusanmi D, Narang AS, Hussain MA, Gamble JF, Tobyn MJ, Heng JYYet al., 2014, Effect of crystal habits on the surface energy and cohesion of crystalline powders, International Journal of Pharmaceutics, Vol: 472, Pages: 140-147, ISSN: 1873-3476

The role of surface properties, influenced by particle processing, in particle–particle interactions (powder cohesion) is investigated in this study. Wetting behaviour of mefenamic acid was found to be anisotropic by sessile drop contact angle measurements on macroscopic (>1 cm) single crystals, with variations in contact angle of water from 56.3° to 92.0°. This is attributed to variations in surface chemical functionality at specific facets, and confirmed using X-ray photoelectron spectroscopy (XPS). Using a finite dilution inverse gas chromatography (FD-IGC) approach, the surface energy heterogeneity of powders was determined. The surface energy profile of different mefenamic acid crystal habits was directly related to the relative exposure of different crystal facets. Cohesion, determined by a uniaxial compression test, was also found to relate to surface energy of the powders. By employing a surface modification (silanisation) approach, the contribution from crystal shape from surface area and surface energy was decoupled. By “normalising” contribution from surface energy and surface area, needle shaped crystals were found to be ∼2.5× more cohesive compared to elongated plates or hexagonal cuboid shapes crystals.

Journal article

Cai X, Heng J, 2014, Particle Science and Engineering, Publisher: Royal Society of Chemistry, ISBN: 9781849739573

Discussing the state of the art research in particle science and technology and their roles in the environment, this book will contain a selection of high quality papers from the UK-China International Particle Technology Forum IV held in ...

Book

Lee K-Y, Blaker JJ, Murakami R, Heng JYY, Bismarck Aet al., 2014, Phase Behavior of Medium and High Internal Phase Water-in-Oil Emulsions Stabilized Solely by Hydrophobized Bacterial Cellulose Nanofibrils, LANGMUIR, Vol: 30, Pages: 452-460, ISSN: 0743-7463

Journal article

Hedberg S, Quigley A, Heng JYY, Williams DR, Liddell Jet al., 2014, Self-interaction chromatography (SIC) of mabs: New methods for estimating the dead volume in SIC and using sic to predict mab stability, Pages: 897-907

Copyright © (2014) by AIChE All rights reserved. Protein-protein molecular interactions are known to be involved in protein solution aggregation behaviour; however the mechanisms leading to protein aggregation are still not fully understood. The osmotic second virial coefficient (B22) is a fundamental physiochemical property that describes proteinprotein interactions in solution, which can be a useful tool to predict aggregation propensity of proteins. This work includes two experimental SIC studies on both model proteins and therapeutic mAbs of different sizes. The first study is an evaluation of two different experimental techniques used to determine SIC dead volumes and the second study uses SIC results for mAb to predict stability. Accurate dead retention volumes are essential for the accurate determinations of B22. The traditional method of estimating dead volume for SIC includes the use of a dead column (without protein immobilised) where the retention volume for proteins can be established. For this technique the dead volume was established for the proteins over a wide range of solution conditions (pH and salt concentrations), and then compared with a new method, where a number of non-interacting dextrans of different molecular weights (MW) (including the MW's of the protein) were employed to find the dead retention volume. The results for the traditional technique with a dead column changed depending on the protein used; only certain model proteins kept a constant dead retention volume when the pH was changing under a constant high salt concentration to minimise protein-surface interactions. Several proteins, including the mAb, exhibited an increased dead retention volume especially when exposed to lower pH. From this it can be concluded that there is no absolute dead volume that can be determined by this technique which are independent of solution conditions. The new technique involving dextrans gives a better overall result for the dead volume for pro

Conference paper

Parambil JV, Poornachary SK, Tan RBH, Heng JYYet al., 2014, Template-induced polymorphic selectivity: the effects of surface chemistry and solute concentration on carbamazepine crystallisation, Crystengcomm, Vol: 16, Pages: 4927-4930, ISSN: 1466-8033

Cooling crystallisation of carbamazepine solution in glass vials functionalised with different silane molecules resulted in preferential nucleation of metastable form II or stable form III polymorphs within a definite range of supersaturation. In contrast, the two crystal forms nucleated concomitantly on a control substrate under similar solution conditions.

Journal article

Ali SSM, Heng JYY, Nikolaev AA, Waters KEet al., 2013, Introducing inverse gas chromatography as a method of determining the surface heterogeneity of minerals for flotation, POWDER TECHNOLOGY, Vol: 249, Pages: 373-377, ISSN: 0032-5910

Journal article

Kwek JW, Heng D, Lee SH, Ng WK, Chan H-K, Adi S, Heng J, Tan RBHet al., 2013, High speed imaging with electrostatic charge monitoring to track powder deagglomeration upon impact, JOURNAL OF AEROSOL SCIENCE, Vol: 65, Pages: 77-87, ISSN: 0021-8502

Journal article

Quigley A, Heng JYY, Liddell JM, Williams DRet al., 2013, The accurate measurement of second virial coefficients using self-interaction chromatography: Experimental considerations, EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, Vol: 85, Pages: 1103-1111, ISSN: 0939-6411

Journal article

Al-Hashmi AR, Luckham PF, Heng JYY, Al-Maamari RS, Zaitoun A, Al-Sharji HH, Al-Wehaibi TKet al., 2013, Adsorption of High-Molecular-Weight EOR Polymers on Glass Surfaces Using AFM and QCM-D, ENERGY & FUELS, Vol: 27, Pages: 2437-2444, ISSN: 0887-0624

Journal article

Poornachary SK, Parambil JV, Chow PS, Tan RBH, Heng JYYet al., 2013, Nucleation of Elusive Crystal Polymorphs at the Solution-Substrate Contact Line, CRYSTAL GROWTH & DESIGN, Vol: 13, Pages: 1180-1186, ISSN: 1528-7483

Journal article

Wang GD, Heng JYY, Williams DR, 2013, Dilatometry of powder compacts - Characterizing amorphous-crystalline transformations, POWDER TECHNOLOGY, Vol: 236, Pages: 12-16, ISSN: 0032-5910

Journal article

Delmas T, Shah UV, Roberts MM, Williams DR, Heng JYYet al., 2013, Crystallisation of the orthorhombic form of acetaminophen: Combined effect of surface topography and chemistry, POWDER TECHNOLOGY, Vol: 236, Pages: 24-29, ISSN: 0032-5910

Journal article

Khoo JY, Shah UV, Schaepertoens M, Williams DR, Heng JYYet al., 2013, Process-induced phase transformation of carbamazepine dihydrate to its polymorphic anhydrates, POWDER TECHNOLOGY, Vol: 236, Pages: 114-121, ISSN: 0032-5910

Journal article

Kwek JW, Heng D, Lee SH, Wai KN, Chan H-K, Heng J, Tan Ret al., 2013, Visualizing Powder De-agglomeration upon Impact with Simultaneous Flowing Charge Behaviour, POWDERS AND GRAINS 2013, Vol: 1542, Pages: 1003-1006, ISSN: 0094-243X

Journal article

Ho R, Heng JYY, 2013, A Review of Inverse Gas Chromatography and its Development as a Tool to Characterize Anisotropic Surface Properties of Pharmaceutical Solids, KONA POWDER AND PARTICLE JOURNAL, Pages: 164-180, ISSN: 0288-4534

Journal article

Kwek JW, Jeyabalasingam M, Ng WK, Heng JYY, Tan RBHet al., 2012, Comparative Study of the Triboelectric Charging Behavior of Powders Using a Nonintrusive Approach, INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH, Vol: 51, Pages: 16488-16494, ISSN: 0888-5885

Journal article

Burnett DJ, Khoo J, Naderi M, Heng JYY, Wang GD, Thielmann Fet al., 2012, Effect of Processing Route on the Surface Properties of Amorphous Indomethacin Measured by Inverse Gas Chromatography, AAPS PHARMSCITECH, Vol: 13, Pages: 1511-1517, ISSN: 1530-9932

Journal article

Ho R, Naderi M, Heng JYY, Williams DR, Thielmann F, Bouza P, Keith AR, Thiele G, Burnett DJet al., 2012, Effect of Milling on Particle Shape and Surface Energy Heterogeneity of Needle-Shaped Crystals, PHARMACEUTICAL RESEARCH, Vol: 29, Pages: 2806-2816, ISSN: 0724-8741

Journal article

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