Imperial College London

DrJerryHeng

Faculty of EngineeringDepartment of Chemical Engineering

Reader in Particle Technology
 
 
 
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Contact

 

+44 (0)20 7594 0784jerry.heng

 
 
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Location

 

417AACE ExtensionSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Parambil:2019:10.1039/c9ce00404a,
author = {Parambil, JV and Poornachary, SK and Heng, JYY and Tan, RBH},
doi = {10.1039/c9ce00404a},
journal = {CrystEngComm},
pages = {4122--4135},
title = {Template-induced nucleation for controlling crystal polymorphism: from molecular mechanisms to applications in pharmaceutical processing},
url = {http://dx.doi.org/10.1039/c9ce00404a},
volume = {21},
year = {2019}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - Over the last two decades, the use of template surfaces to induce heterogeneous crystal nucleation has been explored primarily to address two different goals: first, as an alternative to the conventional seeding technique used for polymorph control and, second, as a technique to promote the nucleation rate in novel crystallisation processes and formulations. The former need conceivably arises due to the risk of crystallising a new polymorph despite pre-seeding the solution with the desired crystal form. In this context, we review ongoing efforts in the research area of template-induced crystallisation, covering both experimental and simulation studies directed towards deeper understanding of the underpinning mechanisms. In addition, we report on the use of template-induced crystal nucleation as a process intensification technology for formulating drug substances and as a technique for enabling nucleation and polymorphic control during continuous manufacturing of active pharmaceutical ingredients.
AU - Parambil,JV
AU - Poornachary,SK
AU - Heng,JYY
AU - Tan,RBH
DO - 10.1039/c9ce00404a
EP - 4135
PY - 2019///
SN - 1466-8033
SP - 4122
TI - Template-induced nucleation for controlling crystal polymorphism: from molecular mechanisms to applications in pharmaceutical processing
T2 - CrystEngComm
UR - http://dx.doi.org/10.1039/c9ce00404a
UR - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000475493400012&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR - http://hdl.handle.net/10044/1/75464
VL - 21
ER -