Imperial College London
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Professor Jerry Heng

Faculty of Engineering, Department of Chemical Engineering

Professor in Particle Technology
 
 
 
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Contact

 

+44 (0)20 7594 0784jerry.heng

 
 
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Location

 

208ACE ExtensionSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Ouyang:2019:10.1016/j.molliq.2019.110885,
author = {Ouyang, J and Zhou, L and Liu, Z and Xiao, S and Huang, X and Heng, JYY},
doi = {10.1016/j.molliq.2019.110885},
journal = {Journal of Molecular Liquids},
title = {Solubility determination and modelling of benzamide in organic solvents at temperatures from 283.15 K and 323.15 K, and ternary phase diagrams of benzamide-benzoic acid cocrystals in ethanol at 298.15 K},
url = {http://dx.doi.org/10.1016/j.molliq.2019.110885},
volume = {286},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - In this paper, several common solvents including butyl acetate, methyl acetate, ethyl acetate, acetonitrile, 1-butanol, isobutanol, isopropanol, ethanol, 1-propanol, methanol, acetone, and water, were selected as solubility solvents for benzamide. The solubility of benzamide in all solvents increases with the increase of temperature from 283.15K to 323.15K, and generally depends on solvents in the following order: methanol>acetone>ethanol>1-propanol>1-butanol>isopropanol>isobutanol>methyl acetate>ethyl acetate>butyl acetate>acetonitrile>water. Solubility data in all solvents were well correlated with the temperature by using the NRTL, Wilson and modified Apelblat models. Furthermore, the dissolution thermodynamic properties, which include dissolution Gibbs energy, dissolution entropy and dissolution enthalpy, were also calculated. Based on the above results, ethanol was chosen as the solvent for preparing benzamide cocrystal with benzoic acid. The ternary phase diagram of benzamide-benzoic acid cocrystals in ethanol was constructed, and one stable cocrystal with a stoichiometry of 1:1 was determined and characterized.
AU  - Ouyang,J
AU  - Zhou,L
AU  - Liu,Z
AU  - Xiao,S
AU  - Huang,X
AU  - Heng,JYY
DO  - 10.1016/j.molliq.2019.110885
PY  - 2019///
SN  - 0167-7322
TI  - Solubility determination and modelling of benzamide in organic solvents at temperatures from 283.15 K and 323.15 K, and ternary phase diagrams of benzamide-benzoic acid cocrystals in ethanol at 298.15 K
T2  - Journal of Molecular Liquids
UR  - http://dx.doi.org/10.1016/j.molliq.2019.110885
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000474308400010&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/109499
VL  - 286
ER  -
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