Imperial College London
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Professor Jerry Heng

Faculty of Engineering, Department of Chemical Engineering

Professor in Particle Technology
 
 
 
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Contact

 

+44 (0)20 7594 0784jerry.heng

 
 
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Location

 

208ACE ExtensionSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Kaur:2023:10.1021/acs.nanolett.3c01271,
author = {Kaur, A and Darvill, D and Xiang, S and Heng, JYY and Petrov, PK and Hoye, RLZ and Chen, R},
doi = {10.1021/acs.nanolett.3c01271},
journal = {Nano Letters},
pages = {6760--6767},
title = {Development of nanopackaging for storage and transport of loaded lipid nanoparticles},
url = {http://dx.doi.org/10.1021/acs.nanolett.3c01271},
volume = {23},
year = {2023}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Easily deploying new vaccines globally to combat disease outbreaks has been highlighted as a major necessity by the World Health Organization. RNA-based vaccines using lipid nanoparticles (LNPs) as a drug delivery system were employed to great effect during the recent COVID-19 pandemic. However, LNPs are still unstable at room temperature and agglomerate over time during storage, rendering them ineffective for intracellular delivery. We demonstrate the suitability of nanohole arrays (nanopackaging) as patterned surfaces to separate and store functionalized LNPs (fLNPs) in individual recesses, which can be expanded to other therapeutics. Encapsulating calcein as a model drug, we show through confocal microscopy the effective loading of fLNPs into our nanopackaging for both wet and dry systems. We prove quantifiably pH-mediated capture and subsequent unloading of over 30% of the fLNPs using QCM-D on alumina surfaces altering the pH from 5.5 to 7, displaying controllable storage at the nanoscale.
AU  - Kaur,A
AU  - Darvill,D
AU  - Xiang,S
AU  - Heng,JYY
AU  - Petrov,PK
AU  - Hoye,RLZ
AU  - Chen,R
DO  - 10.1021/acs.nanolett.3c01271
EP  - 6767
PY  - 2023///
SN  - 1530-6984
SP  - 6760
TI  - Development of nanopackaging for storage and transport of loaded lipid nanoparticles
T2  - Nano Letters
UR  - http://dx.doi.org/10.1021/acs.nanolett.3c01271
UR  - https://pubs.acs.org/doi/10.1021/acs.nanolett.3c01271
UR  - http://hdl.handle.net/10044/1/104849
VL  - 23
ER  -
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