Imperial College London
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Professor Jerry Heng

Faculty of Engineering, Department of Chemical Engineering

Professor in Particle Technology
 
 
 
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Contact

 

+44 (0)20 7594 0784jerry.heng

 
 
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Location

 

208ACE ExtensionSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Jakubec:2017:10.1016/j.colsurfa.2017.03.002,
author = {Jakubec, M and Klimsa, V and Hanus, J and Biegaj, K and Heng, JYY and Stepanek, F},
doi = {10.1016/j.colsurfa.2017.03.002},
journal = {COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS},
pages = {250--259},
title = {Formation of multi-compartmental drug carriers by hetero-aggregation of polyelectrolyte microgels},
url = {http://dx.doi.org/10.1016/j.colsurfa.2017.03.002},
volume = {522},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The formation of drug carriers able to incorporate multiple molecular payloads in separate compartments was investigated, using the hetero-aggregation of oppositely charged hydrogel microparticles as the building blocks. The primary particles – negatively charged alginate and positively charged chitosan microgels with a mean diameter of 6–7 μm – were produced by spray drying with in situ cross-linking. The kinetics of their hetero-aggregation was measured on-line by static light scattering. The effects of the starting stoichiometry (positive:negative particle ratio), hydrodynamic conditions (agitation intensity), and pre-conditioning (dry vs. pre-hydrated primary particles) on the aggregate growth rate were systematically investigated. An optimum stoichiometric ratio of the primary particles was found in each case. The structure of the resulting hetero-aggregates was characterised by laser scanning confocal microscopy and found to strongly depend on the pre-conditioning of the primary particles. While dry primary particles resulted in open, floccular structures, pre-hydrated primary particles gave rise to relatively dense, compact aggregates. The ability to incorporate multiple molecular payloads was demonstrated, providing a platform for the formation of well-defined structures that can be further used in applications such as the encapsulation and release of multiple actives from a single carrier.
AU  - Jakubec,M
AU  - Klimsa,V
AU  - Hanus,J
AU  - Biegaj,K
AU  - Heng,JYY
AU  - Stepanek,F
DO  - 10.1016/j.colsurfa.2017.03.002
EP  - 259
PY  - 2017///
SN  - 0927-7757
SP  - 250
TI  - Formation of multi-compartmental drug carriers by hetero-aggregation of polyelectrolyte microgels
T2  - COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
UR  - http://dx.doi.org/10.1016/j.colsurfa.2017.03.002
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000404491600026&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/49634
VL  - 522
ER  -
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