Imperial College London
Alternate

ProfessorJesusGil

Faculty of Medicine, Institute of Clinical Sciences

Professor of Cell Proliferation
 
 
 
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Contact

 

+44 (0)20 3313 8263jesus.gil

 
 
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Location

 

ICTEM room 230ICTEM buildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Birch:2020:10.1101/gad.337394.120,
author = {Birch, J and Gil, J},
doi = {10.1101/gad.337394.120},
journal = {Genes and Development},
pages = {463--464},
title = {Blunting senescence boosts liver regeneration},
url = {http://dx.doi.org/10.1101/gad.337394.120},
volume = {34},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The mammalian liver possesses a unique capacity for regeneration. However, this regenerative potential declines with age due to unknown mechanisms. In this issue of Genes & Development, Ritschka and colleagues (pp. 489–494). compare liver regeneration upon partial hepatectomy in young and adult mice. Partial hepatectomy causes a transient increase in p21 in a subpopulation of hepatocytes that persists in adult mice. Remarkably, treatment with the BCL-2 family inhibitor ABT-737 blunts p21 expression, enhancing liver regeneration.
AU  - Birch,J
AU  - Gil,J
DO  - 10.1101/gad.337394.120
EP  - 464
PY  - 2020///
SN  - 0890-9369
SP  - 463
TI  - Blunting senescence boosts liver regeneration
T2  - Genes and Development
UR  - http://dx.doi.org/10.1101/gad.337394.120
UR  - http://hdl.handle.net/10044/1/77892
VL  - 34
ER  -
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