Imperial College London
Alternate

ProfessorJesusGil

Faculty of Medicine, Institute of Clinical Sciences

Professor of Cell Proliferation
 
 
 
//

Contact

 

+44 (0)20 3313 8263jesus.gil

 
 
//

Location

 

ICTEM room 230ICTEM buildingHammersmith Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Adrados:2015:10.1038/onc.2015.408,
author = {Adrados, I and Larrasa-Alonso, J and Galarreta, A and López-Antona, I and Menéndez, C and Abad, M and Gil, J and Moreno-Bueno, G and Palmero, I},
doi = {10.1038/onc.2015.408},
journal = {Oncogene},
pages = {3485--3494},
title = {The homeoprotein SIX1 controls cellular senescence through the regulation of p16INK4A and differentiation-related genes.},
url = {http://dx.doi.org/10.1038/onc.2015.408},
volume = {35},
year = {2015}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Cellular senescence is an antiproliferative response with essential functions in tumor suppression and tissue homeostasis. Here we show that SIX1, a member of the SIX family of homeobox transcriptional factors, is a novel repressor of senescence. Our data show that SIX1 is specifically downregulated in fibroblasts upon oncogenic stress and other pro-senescence stimuli, as well as in senescent skin premalignant lesions. Silencing of SIX1 in human fibroblasts suffices to trigger senescence, which is mediated by p16INK4A and lacks a canonical senescence-associated secretory phenotype. Interestingly, SIX1-associated senescence is further characterized by the expression of a set of development and differentiation-related genes that significantly overlap with genes associated with SIX1 in organogenesis or human tumors, and show coincident regulation in oncogene-induced senescence. Mechanistically, we show that gene regulation by SIX1 during senescence is mediated, at least in part, by cooperation with Polycomb repressive complexes. In summary, our results identify SIX1, a key development regulator altered in human tumors, as a critical repressor of cellular senescence, providing a novel connection between senescence, differentiation and tumorigenesis.
AU  - Adrados,I
AU  - Larrasa-Alonso,J
AU  - Galarreta,A
AU  - López-Antona,I
AU  - Menéndez,C
AU  - Abad,M
AU  - Gil,J
AU  - Moreno-Bueno,G
AU  - Palmero,I
DO  - 10.1038/onc.2015.408
EP  - 3494
PY  - 2015///
SN  - 1476-5594
SP  - 3485
TI  - The homeoprotein SIX1 controls cellular senescence through the regulation of p16INK4A and differentiation-related genes.
T2  - Oncogene
UR  - http://dx.doi.org/10.1038/onc.2015.408
VL  - 35
ER  -
Download