Imperial College London
Alternate

ProfessorJesusGil

Faculty of Medicine, Institute of Clinical Sciences

Professor of Cell Proliferation
 
 
 
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Contact

 

+44 (0)20 3313 8263jesus.gil

 
 
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Location

 

ICTEM room 230ICTEM buildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Georgilis:2016:10.1101/gad.288571.116,
author = {Georgilis, A and Gil, J},
doi = {10.1101/gad.288571.116},
journal = {Genes & Development},
pages = {1791--1792},
title = {Controlling secretion to limit chemoresistance},
url = {http://dx.doi.org/10.1101/gad.288571.116},
volume = {30},
year = {2016}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The tumor microenvironment influences cancer progression and therapy outcome bymechanisms not yet fully understood. In this issue, Bent et al. (2016) show howchemotherapy causes endothelial senescence. Interestingly, senescent endothelial cells donot mount a typical senescence-associated secretory phenotype but instead acutely secreteIL-6, promoting chemoresistance. This study unveils a physiological switch involvingPI3K/AKT/mTOR signaling that restrains the senescence secretory responses to limit thedetrimental consequences of persistent inflammation.
AU  - Georgilis,A
AU  - Gil,J
DO  - 10.1101/gad.288571.116
EP  - 1792
PY  - 2016///
SN  - 1549-5477
SP  - 1791
TI  - Controlling secretion to limit chemoresistance
T2  - Genes & Development
UR  - http://dx.doi.org/10.1101/gad.288571.116
UR  - http://hdl.handle.net/10044/1/38769
VL  - 30
ER  -
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