Imperial College London

Joanne P. Webster

Faculty of MedicineSchool of Public Health

Visiting Professor
 
 
 
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Contact

 

+44 (0)20 7594 3636joanne.webster Website

 
 
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Location

 

Medical SchoolSt Mary's Campus

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Summary

 

Publications

Publication Type
Year
to

164 results found

Antonovics J, Wilson AJ, Forbes MR, Hauffe HC, Kallio ER, Leggett HC, Longdon B, Okamura B, Sait SM, Webster JPet al., 2017, The evolution of transmission mode., Philos Trans R Soc Lond B Biol Sci, Vol: 372

This article reviews research on the evolutionary mechanisms leading to different transmission modes. Such modes are often under genetic control of the host or the pathogen, and often in conflict with each other via trade-offs. Transmission modes may vary among pathogen strains and among host populations. Evolutionary changes in transmission mode have been inferred through experimental and phylogenetic studies, including changes in transmission associated with host shifts and with evolution of the unusually complex life cycles of many parasites. Understanding the forces that determine the evolution of particular transmission modes presents a fascinating medley of problems for which there is a lack of good data and often a lack of conceptual understanding or appropriate methodologies. Our best information comes from studies that have been focused on the vertical versus horizontal transmission dichotomy. With other kinds of transitions, theoretical approaches combining epidemiology and population genetics are providing guidelines for determining when and how rapidly new transmission modes may evolve, but these are still in need of empirical investigation and application to particular cases. Obtaining such knowledge is a matter of urgency in relation to extant disease threats.This article is part of the themed issue 'Opening the black box: re-examining the ecology and evolution of parasite transmission'.

JOURNAL ARTICLE

Easton AV, Oliveira RG, Walker M, O'Connell EM, Njenga SM, Mwandawiro CS, Webster JP, Nutman TB, Anderson RMet al., 2017, Sources of variability in the measurement of Ascaris lumbricoides infection intensity by Kato-Katz and qPCR, PARASITES & VECTORS, Vol: 10, ISSN: 1756-3305

JOURNAL ARTICLE

Leger E, Webster JP, 2017, Hybridizations within the Genus Schistosoma: implications for evolution, epidemiology and control., Parasitology, Vol: 144, Pages: 65-80

Hybridization of parasites is an emerging public health concern in our changing world. Hybridization and introgression in parasites and pathogens can have major impacts on the host and the epidemiology and evolution of disease. Schistosomiasis is a Neglected Tropical Disease of profound medical and veterinary importance across many parts of the world, with the greatest human burden within sub-Saharan Africa. Here we review how early phenotypic identification and recent confirmation through molecular studies on naturally occurring infections, combined with experimental manipulations, have revealed evidence of viable hybridization and introgressions within and between human and animal schistosome species. Environmental and anthropogenic changes in selective pressures following, for instance, new dam constructions, altered agricultural practices, together with mass drug administration programmes, may all be predicted to further impact the availability of suitable definitive and intermediate hosts for schistosomes. It is therefore imperative to understand the distribution and role of such novel zoonotic hybrid schistosomes on host range, drug efficacy, and hence ultimately transmission potential, if we are to achieve and maintain sustainable control.

JOURNAL ARTICLE

Pitaksakulrat O, Kiatsopit N, Laoprom N, Webster BL, Webster JP, Lamberton PHL, Laha T, Andrews RH, Petney TN, Blair D, Carlton EJ, Spear RC, Sithithaworn Pet al., 2017, Preliminary genetic evidence of two different populations of Opisthorchis viverrini in Lao PDR, PARASITOLOGY RESEARCH, Vol: 116, Pages: 1247-1256, ISSN: 0932-0113

JOURNAL ARTICLE

Webster JP, Borlase A, Rudge JW, 2017, Who acquires infection from whom and how? Disentangling multi-host and multi-mode transmission dynamics in the 'elimination' era., Philos Trans R Soc Lond B Biol Sci, Vol: 372

Multi-host infectious agents challenge our abilities to understand, predict and manage disease dynamics. Within this, many infectious agents are also able to use, simultaneously or sequentially, multiple modes of transmission. Furthermore, the relative importance of different host species and modes can itself be dynamic, with potential for switches and shifts in host range and/or transmission mode in response to changing selective pressures, such as those imposed by disease control interventions. The epidemiology of such multi-host, multi-mode infectious agents thereby can involve a multi-faceted community of definitive and intermediate/secondary hosts or vectors, often together with infectious stages in the environment, all of which may represent potential targets, as well as specific challenges, particularly where disease elimination is proposed. Here, we explore, focusing on examples from both human and animal pathogen systems, why and how we should aim to disentangle and quantify the relative importance of multi-host multi-mode infectious agent transmission dynamics under contrasting conditions, and ultimately, how this can be used to help achieve efficient and effective disease control.This article is part of the themed issue 'Opening the black box: re-examining the ecology and evolution of parasite transmission'.

JOURNAL ARTICLE

Crellen T, Allan F, David S, Durrant C, Huckvale T, Holroyd N, Emery AM, Rollinson D, Aanensen DM, Berriman M, Webster JP, Cotton JAet al., 2016, Whole genome resequencing of the human parasite Schistosoma mansoni reveals population history and effects of selection, SCIENTIFIC REPORTS, Vol: 6, ISSN: 2045-2322

JOURNAL ARTICLE

Crellen T, Walker M, Lamberton PHL, Kabatereine NB, Tukahebwa EM, Cotton JA, Webster JPet al., 2016, Reduced Efficacy of Praziquantel Against Schistosoma mansoni Is Associated With Multiple Rounds of Mass Drug Administration, CLINICAL INFECTIOUS DISEASES, Vol: 63, Pages: 1151-1159, ISSN: 1058-4838

JOURNAL ARTICLE

Deol A, Webster JP, Walker M, Basanez M-G, Hollingsworth TD, Fleming FM, Montresor A, French MDet al., 2016, Development and evaluation of a Markov model to predict changes in schistosomiasis prevalence in response to praziquantel treatment: a case study of Schistosoma mansoni in Uganda and Mali, PARASITES & VECTORS, Vol: 9, ISSN: 1756-3305

JOURNAL ARTICLE

Easton AV, Oliveira RG, O'Connell EM, Kepha S, Mwandawiro CS, Njenga SM, Kihara JH, Mwatele C, Odiere MR, Brooker SJ, Webster JP, Anderson RM, Nutman TBet al., 2016, Multi-parallel qPCR provides increased sensitivity and diagnostic breadth for gastrointestinal parasites of humans: field-based inferences on the impact of mass deworming, PARASITES & VECTORS, Vol: 9, ISSN: 1756-3305

JOURNAL ARTICLE

Fleming FM, Matovu F, Hansen KS, Webster JPet al., 2016, A mixed methods approach to evaluating community drug distributor performance in the control of neglected tropical diseases, PARASITES & VECTORS, Vol: 9, ISSN: 1756-3305

JOURNAL ARTICLE

L├ęger E, Garba A, Hamidou AA, Webster BL, Pennance T, Rollinson D, Webster JPet al., 2016, Introgressed animal schistosomes schistosoma curassoni and S. Bovis naturally infecting humans, Emerging Infectious Diseases, Vol: 22, Pages: 2212-2214, ISSN: 1080-6040

JOURNAL ARTICLE

Petney TN, Sithithaworn P, Andrews RH, Webster JPet al., 2016, Foodborne trematodes: a diverse and challenging group of neglected parasites, TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, Vol: 110, Pages: 1-3, ISSN: 0035-9203

JOURNAL ARTICLE

Webster JP, Gower CM, Knowles SCL, Molyneux DH, Fenton Aet al., 2016, One health - an ecological and evolutionary framework for tackling Neglected Zoonotic Diseases, EVOLUTIONARY APPLICATIONS, Vol: 9, Pages: 313-333, ISSN: 1752-4571

JOURNAL ARTICLE

Webster JP, Lamberton PHL, McConkey GA, 2016, The Toxoplasma gondii Model of Schizophrenia, Handbook of Behavioral Neuroscience, Pages: 225-241

BOOK CHAPTER

Albonico M, Levecke B, LoVerde PT, Montresor A, Prichard R, Vercruysse J, Webster JPet al., 2015, Monitoring the efficacy of drugs for neglected tropical diseases controlled by preventive chemotherapy, JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE, Vol: 3, Pages: 229-236, ISSN: 2213-7165

JOURNAL ARTICLE

Deol AK, Webster JP, Harrison W, Basanez MG, Walker M, Hollingsworth TD, Montresor A, Fernandes J, Fenwick A, French Met al., 2015, Development of a Markov transition probability model to predict changes in schistosomiasis infection following treatment, TROPICAL MEDICINE & INTERNATIONAL HEALTH, Vol: 20, Pages: 237-237, ISSN: 1360-2276

JOURNAL ARTICLE

French MD, Churcher TS, Webster JP, Fleming FM, Fenwick A, Kabatereine NB, Sacko M, Garba A, Toure S, Nyandindi U, Mwansa J, Blair L, Bosque-Oliva E, Basanez M-Get al., 2015, Estimation of changes in the force of infection for intestinal and urogenital schistosomiasis in countries with schistosomiasis control initiative-assisted programmes, PARASITES & VECTORS, Vol: 8, ISSN: 1756-3305

JOURNAL ARTICLE

King KC, Stelkens RB, Webster JP, Smith DF, Brockhurst MAet al., 2015, Hybridization in Parasites: Consequences for Adaptive Evolution, Pathogenesis, and Public Health in a Changing World, PLOS PATHOGENS, Vol: 11, ISSN: 1553-7366

JOURNAL ARTICLE

Knowles SCL, Webster BL, Garba A, Sacko M, Diaw OT, Fenwick A, Rollinson D, Webster JPet al., 2015, Epidemiological Interactions between Urogenital and Intestinal Human Schistosomiasis in the Context of Praziquantel Treatment across Three West African Countries, PLoS Neglected Tropical Diseases, Vol: 9, ISSN: 1935-2735

JOURNAL ARTICLE

Lamberton PHL, Crellen T, Cotton JA, Webster JPet al., 2015, Modelling the Effects of Mass Drug Administration on the Molecular Epidemiology of Schistosomes, MATHEMATICAL MODELS FOR NEGLECTED TROPICAL DISEASES: ESSENTIAL TOOLS FOR CONTROL AND ELIMINATION, PT A, Vol: 87, Pages: 293-327, ISSN: 0065-308X

JOURNAL ARTICLE

Lamberton PHL, Crellen T, Cotton JA, Webster JPet al., 2015, Modelling the Effects of Mass Drug Administration on the Molecular Epidemiology of Schistosomes, Advances in Parasitology, Vol: 87, Pages: 293-327, ISSN: 0065-308X

JOURNAL ARTICLE

Webster BL, Rabone M, Pennance T, Emery AM, Allan F, Gouvras A, Knopp S, Garba A, Hamidou AA, Mohammed KA, Ame SM, Rollinson D, Webster JPet al., 2015, Development of novel multiplex microsatellite polymerase chain reactions to enable high-throughput population genetic studies of Schistosoma haematobium, PARASITES & VECTORS, Vol: 8, ISSN: 1756-3305

JOURNAL ARTICLE

Webster BL, Rabone M, Pennance T, Emery AM, Allan F, Gouvras A, Knopp S, Garba A, Hamidou AA, Mohammed KA, Ame SM, Rollinson D, Webster JPet al., 2015, Development of novel multiplex microsatellite polymerase chain reactions to enable high-throughput population genetic studies of Schistosoma haematobium (vol 8, 432, 2015), PARASITES & VECTORS, Vol: 8, ISSN: 1756-3305

JOURNAL ARTICLE

Kaushik M, Knowles SCL, Webster JP, 2014, What Makes a Feline Fatal in Toxoplasma gondii's Fatal Feline Attraction? Infected Rats Choose Wild Cats, INTEGRATIVE AND COMPARATIVE BIOLOGY, Vol: 54, Pages: 118-128, ISSN: 1540-7063

JOURNAL ARTICLE

Lamberton PHL, Kabatereine NB, Oguttu DW, Fenwick A, Webster JPet al., 2014, Sensitivity and Specificity of Multiple Kato-Katz Thick Smears and a Circulating Cathodic Antigen Test for Schistosoma mansoni Diagnosis Pre- and Post-repeated-Praziquantel Treatment, PLOS NEGLECTED TROPICAL DISEASES, Vol: 8, ISSN: 1935-2735

JOURNAL ARTICLE

Webster JP, Kaushik M, 2014, The impact of Toxoplasma gondii on host behaviour: can this parasite play a role in some cases of human schizophrenia?, Annual Meeting of the Society-for-Integrative-and-Comparative-Biology, Publisher: OXFORD UNIV PRESS INC, Pages: E221-E221, ISSN: 1540-7063

CONFERENCE PAPER

Webster JP, Molyneux DH, Hotez PJ, Fenwick Aet al., 2014, The contribution of mass drug administration to global health: past, present and future, PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, Vol: 369, ISSN: 0962-8436

JOURNAL ARTICLE

Adamo SA, Webster JP, 2013, Neural parasitology: how parasites manipulate host behaviour, JOURNAL OF EXPERIMENTAL BIOLOGY, Vol: 216, Pages: 1-2, ISSN: 0022-0949

JOURNAL ARTICLE

French MD, Churcher TS, Basanez M-G, Norton AJ, Lwambo NJS, Webster JPet al., 2013, Reductions in genetic diversity of Schistosoma mansoni populations under chemotherapeutic pressure: the effect of sampling approach and parasite population definition, ACTA TROPICA, Vol: 128, Pages: 196-205, ISSN: 0001-706X

JOURNAL ARTICLE

Garba A, Lamine MS, Barkire N, Djibo A, Sofo B, Gouvras AN, Labbo R, Sebangou H, Webster JP, Fenwick A, Utzinger Jet al., 2013, Efficacy and safety of two closely spaced doses of praziquantel against Schistosoma haematobium and S. mansoni and re-infection patterns in school-aged children in Niger, ACTA TROPICA, Vol: 128, Pages: 334-344, ISSN: 0001-706X

JOURNAL ARTICLE

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