Imperial College London

DrJohannaRhodes

Faculty of MedicineSchool of Public Health

ARC Early Career Research Fellowship
 
 
 
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Contact

 

+44 (0)20 7594 1932johanna.rhodes

 
 
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Location

 

VC9Medical SchoolSt Mary's Campus

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Summary

 

Summary

The UK has the second highest number of adults with cystic fibrosis (CF) in the world (behind the USA), with 10,583 registered patients (CF UK registry 2014). Over the past decade, new therapies for the treatment of cystic fibrosis have improved the life expectancy and quality of life of patients. Simultaneously, azole resistance has emerged in the pathogenic fungus Aspergillus fumigatus, which has been associated with treatment failure in patients with aspergillosis. A recent study conducted at Manchester University found that approximately 50% of CF patients in over 30 countries were infected with A. fumigatus, and more than half of these patients are also over the age of 18. Multi-drug resistant A. fumigatus is now having a negative impact on the lives of CF patients, causing an accelerated decline in lung function. Therefore, there is high demand for research into the prevalence of drug-resistant A. fumigatus within our NHS hospitals, as well as working towards describing resistance mutations and improving rapid diagnosis.

I am currently an early career research fellow as part of Imperial College’s Antimicrobial Research Collaborative, improving methods of diagnosis of drug resistant A. fumigatus within the CF cohort using nanopore sequencing technology.

I am also continuing my research on the fungal pathogen Cryptococcus neoformans, which predominantly infects immunocompromised individuals, and is responsible for almost a quarter of AIDS-related deaths in Africa.

Publications

Journals

Abdolrasouli A, Bercusson AC, Rhodes JL, et al., Airway persistence by the emerging multi-azole-resistant Rasamsonia argillacea complex in cystic fibrosis, Mycoses, ISSN:0933-7407

Nash A, Sewell T, Farrer RA, et al., 2018, Mardy: Mycology Antifungal Resistance Database, Medical Mycology, Vol:56, ISSN:1369-3786, Pages:S152-S152

Rhodes J, Fisher MC, 2018, Breaching Pathogeographic Barriers by the Bat White-Nose Fungus, Mbio, Vol:9, ISSN:2150-7511

Conference

Abdolrasouli A, Rhodes JL, Sewell TR, et al., 2018, Occurrence of triazole resistance in Aspergillus fumigatus among respiratory patients in a specialized cardio-thoracic centre, London, United Kingdom, OXFORD UNIV PRESS, Pages:S76-S76, ISSN:1369-3786

Sewell TR, Rhodes JL, Hagen F, et al., 2018, AfumID: An R Shiny application for Aspergillus fumigatus genotyping, OXFORD UNIV PRESS, Pages:S65-S65, ISSN:1369-3786

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