Imperial College London

DrJohannaRhodes

Faculty of MedicineSchool of Public Health

ARC Early Career Research Fellowship
 
 
 
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Contact

 

+44 (0)20 7594 1932johanna.rhodes

 
 
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Location

 

VC9Medical SchoolSt Mary's Campus

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Summary

 

Summary

The UK has the second highest number of adults with cystic fibrosis (CF) in the world (behind the USA), with 10,583 registered patients (CF UK registry 2014). Over the past decade, new therapies for the treatment of cystic fibrosis have improved the life expectancy and quality of life of patients. Simultaneously, azole resistance has emerged in the pathogenic fungus Aspergillus fumigatus, which has been associated with treatment failure in patients with aspergillosis. A recent study conducted at Manchester University found that approximately 50% of CF patients in over 30 countries were infected with A. fumigatus, and more than half of these patients are also over the age of 18. Multi-drug resistant A. fumigatus is now having a negative impact on the lives of CF patients, causing an accelerated decline in lung function. Therefore, there is high demand for research into the prevalence of drug-resistant A. fumigatus within our NHS hospitals, as well as working towards describing resistance mutations and improving rapid diagnosis.

I am currently an early career research fellow as part of Imperial College’s Antimicrobial Research Collaborative, improving methods of diagnosis of drug resistant A. fumigatus within the CF cohort using nanopore sequencing technology.

I am also continuing my research on the fungal pathogen Cryptococcus neoformans, which predominantly infects immunocompromised individuals, and is responsible for almost a quarter of AIDS-related deaths in Africa.

Publications

Journals

Rhodes J, Fisher MC, 2019, Global epidemiology of emerging Candida auris, Current Opinion in Microbiology, Vol:52, ISSN:1369-5274, Pages:84-89

Rhodes J, 2019, Rapid worldwide emergence of pathogenic fungi, Cell Host & Microbe, Vol:26, ISSN:1931-3128, Pages:12-14

Sewell TR, Zhang Y, Brackin AP, et al., 2019, Elevated prevalence of azole resistant Aspergillus fumigatus in urban versus rural environments in the United Kingdom., Antimicrob Agents Chemother

Sewell T, Zhu J, Rhodes J, et al., 2019, Non-random distribution of azole resistance across the global population of Aspergillus fumigatus, Mbio, Vol:10, ISSN:2150-7511

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