Every breath we take, we inhale a vast array of bacteria, viruses and fungi and yet we do not get infected every time we breath in. My group aims to understand what prevents symptomatic respiratory infections. This is multi-layered and looks at all levels of the immune response.
To answer why we get infected, we have developed a range of in vivo and in vitro models of infection and vaccination in early life, including RSV, Influenza, Pseudomonas aeruginosa, Staphylococcus aureus, Acinetobacter baumannii and non-typeable Haemophilus influenzae (ntHi).
I did my Post-Doc at Imperial College with Prof Peter Openshaw, working on RSV. For my PhD I worked on the development of a tetanus vaccine expressed in the chloroplasts of transgenic tobacco plants in the labs of Professors Peter Nixon and Gordon Dougan, also at Imperial College. I studied genetics at Downing College, University of Cambridge.
I blog about science and academic careers. I have written for Nature, Science, Times Higher Education and The Guardian.
During the COVID19 lockdown, I wrote a weekly diary for the Nature Career Column.
I have experience of working with biotech companies to perform pre-clinical assessment of vaccines to RSV and influenza. This uses our well established infection models and we are open to further collaborations. We are open for new collaborations.
Members of Group
David Stirling, PhD Student working on DNA vaccines
Emily Brown, PhD Student developing new drugs targeting bacterial glucose uptake
Sophie Higham, PhD Student working on antibodies against bacterial infection
Ziyin Wang, PhD Student working on sickness behaviours after lung infection
Felicity Zhang, RT working on RSV clinical isolates
Katie Flight, RT working on CEPI RNA vaccine project (co-supervised by Robin Shattock)
Dr Jacqueline McDonald (RA), worked on signatures of Vaccine safety
Dr Adam Walters (RA), worked on DNA vaccine constructs
Dr Laura Lambert (RA), worked on RNA vaccines
Dr Alex Badamchi Zadeh (PhD Student), co-supervised with Robin Shattock
Dr Matthew Siggins (RA), worked on ntHi vaccines
Dr Ryan Russell (PhD Student), worked on Novel adjuvants
Dr Simren Gill (PhD and Fellowship), worked on Pseudomonas aeruginosa
Ms Miko Zhong (MPhil), worked on neonatal immune response
Dr Katya Kinnear (PhD and Post Doc), worked on DNA vaccines with Touchlight Genetics
Ms Victoria Gould (RA), worked on IgA response to influenza
Dr Charanjit Singh (RA), worked on Ciliate derived vaccines
Dr Helen Groves (PhD student), worked on effect of infection on microbiome
Dr David Busse (PhD student), worked on ISG function in RSV
Dr Jonny Brown, (Post-Doc) worked on anti-viral vaccines
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