Imperial College London
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Dr John S Tregoning

Faculty of Medicine, Department of Infectious Disease

Professor in Vaccine Immunology
 
 
 
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Contact

 

john.tregoning Website

 
 
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Location

 

456 (Shattock Group)Wright Fleming WingSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Tregoning:2020:10.1038/s41541-020-0177-6,
author = {Tregoning, J and Weiner, J and Cizmeci, D and Hake, D and Maertzdorf, J and Kaufmann, SHE and Leroux-Roels, G and Maes, C and Aerssens, A and Calvert, A and Jones, CE},
doi = {10.1038/s41541-020-0177-6},
journal = {npj Vaccines},
title = {Pregnancy has a minimal impact on the acute transcriptional signature to vaccination},
url = {http://dx.doi.org/10.1038/s41541-020-0177-6},
volume = {5},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Vaccination in pregnancy is an effective tool to protect both the mother and infant; vaccines against influenza, pertussis and tetanus are currently recommended. A number of vaccines with a specific indication for use in pregnancy are in development, with the specific aim of providing passive humoral immunity to the newborn child against pathogens responsible for morbidity and mortality in young infants. However, the current understanding about the immune response to vaccination in pregnancy is incomplete. We analysed the effect of pregnancy on early transcriptional responses to vaccination. This type of systems vaccinology approach identifies genes and pathways that are altered in response to vaccination and can be used to understand both the acute inflammation in response to the vaccine and to predict immunogenicity. Pregnant women and mice were immunised with Boostrix-IPV, a multivalent vaccine, which contains three pertussis antigens. Blood was collected from women before and after vaccination and RNA extracted for analysis by microarray. While there were baseline differences between pregnant and non-pregnant women, vaccination induced characteristic patterns of gene expression, with upregulation in interferon response and innate immunity gene modules, independent of pregnancy. We saw similar patterns of responses in both women and mice, supporting the use of mice for preclinical screening of novel maternal vaccines. Using a systems vaccinology approach in pregnancy demonstrated that pregnancy does not affect the initial response to vaccination and that studies in non-pregnant women can provide information about vaccine immunogenicity and potentially safety.
AU  - Tregoning,J
AU  - Weiner,J
AU  - Cizmeci,D
AU  - Hake,D
AU  - Maertzdorf,J
AU  - Kaufmann,SHE
AU  - Leroux-Roels,G
AU  - Maes,C
AU  - Aerssens,A
AU  - Calvert,A
AU  - Jones,CE
DO  - 10.1038/s41541-020-0177-6
PY  - 2020///
SN  - 2059-0105
TI  - Pregnancy has a minimal impact on the acute transcriptional signature to vaccination
T2  - npj Vaccines
UR  - http://dx.doi.org/10.1038/s41541-020-0177-6
UR  - http://hdl.handle.net/10044/1/77803
VL  - 5
ER  -
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