Imperial College London
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Dr John S Tregoning

Faculty of Medicine, Department of Infectious Disease

Professor in Vaccine Immunology
 
 
 
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Contact

 

john.tregoning Website

 
 
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Location

 

456 (Shattock Group)Wright Fleming WingSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{McDonald:2017:10.1111/imm.12742,
author = {McDonald, JU and Zhong, Z and Groves, HT and Tregoning, JS},
doi = {10.1111/imm.12742},
journal = {Immunology},
pages = {451--463},
title = {Inflammatory responses to influenza vaccination at the extremes of age.},
url = {http://dx.doi.org/10.1111/imm.12742},
volume = {151},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Age affects the immune response to vaccination, with individuals at the extremes of age responding poorly. The initial inflammatory response to antigenic materials shapes the subsequent adaptive response and so understanding is required about the effect of age on the profile of acute inflammatory mediators. In this study we measured the local and systemic inflammatory response after influenza vaccination or infection in neonatal, young adult and aged mice. Mice were immunized intramuscularly with inactivated influenza vaccine with and without the adjuvant MF59 and then challenged with H1N1 influenza. Age was the major factor affecting the inflammatory profile after vaccination: neonatal mice had more interleukin-1α (IL-1α), C-reactive protein (CRP) and granulocyte-macrophage colony-stimulating factor (GMCSF), young adults more tumour necrosis factor-α (TNF), and elderly mice more interleukin-1 receptor antagonist (IL-1RA), IL-2RA and interferon-γ-induced protein 10 (IP10). Notably the addition of MF59 induced IL-5, granulocyte colony-stimulating factor (G-CSF), Keratinocyte Chemotractant (KC) and monocyte chemoattractant protein 1 (MCP1) in all ages of animals and levels of these cytokines correlated with antibody responses. Age also had an impact on the efficacy of vaccination: neonatal and young adult mice were protected against challenge, but aged mice were not. There were striking differences in the localization of the cytokine response depending on the route of exposure: vaccination led to a high serum response whereas intranasal infection led to a low serum response but a high lung response. In conclusion, we demonstrate that age affects the inflammatory response to both influenza vaccination and infection. These age-induced differences need to be considered when developing vaccination strategies for different age groups.
AU  - McDonald,JU
AU  - Zhong,Z
AU  - Groves,HT
AU  - Tregoning,JS
DO  - 10.1111/imm.12742
EP  - 463
PY  - 2017///
SN  - 0019-2805
SP  - 451
TI  - Inflammatory responses to influenza vaccination at the extremes of age.
T2  - Immunology
UR  - http://dx.doi.org/10.1111/imm.12742
UR  - http://hdl.handle.net/10044/1/48097
VL  - 151
ER  -
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