Imperial College London
Portrait Picture

Dr John S Tregoning

Faculty of Medicine, Department of Infectious Disease

Professor in Vaccine Immunology
 
 
 
//

Contact

 

john.tregoning Website

 
 
//

Location

 

456 (Shattock Group)Wright Fleming WingSt Mary's Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Gould:2017:10.3389/fmicb.2017.00900,
author = {Gould, VMW and Francis, JN and Anderson, KJ and Georges, B and Cope, AV and Tregoning, JS},
doi = {10.3389/fmicb.2017.00900},
journal = {Frontiers in Microbiology},
title = {Nasal IgA provides protection against human influenza challenge in volunteers with low serum influenza antibody titre},
url = {http://dx.doi.org/10.3389/fmicb.2017.00900},
volume = {8},
year = {2017}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - In spite of there being a number of vaccines, influenza remains a significant global cause of morbidity and mortality. Understanding more about natural and vaccine induced immune protection against influenza infection would help to develop better vaccines. Virus specific IgG is a known correlate of protection, but other factors may help to reduce viral load or disease severity, for example IgA. In the current study we measured influenza specific responses in a controlled human infection model using influenza A/California/2009 (H1N1) as the challenge agent. Volunteers were pre-selected with low haemagglutination inhibition (HAI) titres in order to ensure a higher proportion of infection; this allowed us to explore the role of other immune correlates. In spite of HAI being uniformly low, there were variable levels of H1N1 specific IgG and IgA prior to infection. There was also a range of disease severity in volunteers allowing us to compare whether differences in systemic and local H1N1 specific IgG and IgA prior to infection affected disease outcome. H1N1 specific IgG level before challenge did not correlate with protection, probably due to the pre-screening for individuals with low HAI. However, the length of time infectious virus was recovered from the nose was reduced in patients with higher pre-existing H1N1 influenza specific nasal IgA or serum IgA. Therefore, IgA contributes to protection against influenza and should be targeted in vaccines.
AU  - Gould,VMW
AU  - Francis,JN
AU  - Anderson,KJ
AU  - Georges,B
AU  - Cope,AV
AU  - Tregoning,JS
DO  - 10.3389/fmicb.2017.00900
PY  - 2017///
SN  - 1664-302X
TI  - Nasal IgA provides protection against human influenza challenge in volunteers with low serum influenza antibody titre
T2  - Frontiers in Microbiology
UR  - http://dx.doi.org/10.3389/fmicb.2017.00900
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000401580600001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/49102
VL  - 8
ER  -
Download