Imperial College London

ProfessorJonathanLamb

Faculty of Natural SciencesDepartment of Life Sciences

Senior Research Investigator
 
 
 
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Contact

 

+44 (0)20 7594 9723jonathan.lamb

 
 
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Location

 

6166Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Publications

Publication Type
Year
to

182 results found

Zhang R, Lin Z, Fu M, Guan X, Yu J, Zhong W, Zeng J, Lui VCH, Tam PKH, Lamb JR, Xia H, Chen Yet al., 2018, The Role of Neonatal Gr-1(+) Myeloid Cells in a Murine Model of Rhesus-Rotavirus-Induced Biliary Atresia, AMERICAN JOURNAL OF PATHOLOGY, Vol: 188, Pages: 2617-2628, ISSN: 0002-9440

Journal article

Zhang R-Z, Zeng X-H, Lin Z-F, Ming-Fu, Tong Y-L, Lui VCH, Tam PKH, Lamb JR, Xia H-M, Chen Yet al., 2018, Downregulation of Hes1 expression in experimental biliary atresia and its effects on bile duct structure, WORLD JOURNAL OF GASTROENTEROLOGY, Vol: 24, Pages: 3260-3272, ISSN: 1007-9327

Journal article

Zhang R, Lin Z, Lui VCH, Wong KKY, Tam PKH, Lee P, Lok CN, Lamb JR, Chen Y, Xia Het al., 2017, Silver nanoparticle treatment ameliorates biliary atresia syndrome in rhesus rotavirus inoculated mice, NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, Vol: 13, Pages: 1041-1050, ISSN: 1549-9634

Journal article

Progatzky F, Cook HT, Lamb JR, Bugeon L, Dallman MJet al., 2016, Mucosal inflammation at the respiratory interface: a zebrafish model, AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, Vol: 310, Pages: L551-L561, ISSN: 1040-0605

Journal article

Zhang R-Z, Yu J-K, Peng J, Wang F-H, Liu H-Y, Lui VCH, Nicholls JM, Tam PKH, Lamb JR, Chen Y, Xia H-Met al., 2016, Role of CD56-expressing immature biliary epithelial cells in biliary atresia, WORLD JOURNAL OF GASTROENTEROLOGY, Vol: 22, Pages: 2545-2557, ISSN: 1007-9327

Journal article

Peng J, Tsang JY, Ho DH, Zhang R, Xiao H, Li D, Zhu J, Wang F, Bian Z, Lui VC, Xu A, Tam PK, Lamb JR, Xia H, Chen Yet al., 2015, Modulatory effects of adiponectin on the polarization of tumor-associated macrophages, INTERNATIONAL JOURNAL OF CANCER, Vol: 137, Pages: 848-858, ISSN: 0020-7136

Journal article

Progatzky F, Sangha NJ, Yoshida N, McBrien M, Cheung J, Shia A, Scott J, Marchesi JR, Lamb JR, Bugeon L, Dallman MJet al., 2014, Dietary cholesterol directly induces acute inflammasome-dependent intestinal inflammation, NATURE COMMUNICATIONS, Vol: 5, ISSN: 2041-1723

Journal article

Progatzky F, Sangha NJ, Yoshida N, McBrien M, Cheung J, Shia A, Scott J, Marchesi JR, Lamb JR, Bugeon L, Dallman MJet al., 2014, Intestinal inflammation induced by dietary cholesterol in Zebrafish, 9th European-Mucosal-Immunology-Group Meeting, Publisher: WILEY-BLACKWELL, Pages: 27-28, ISSN: 0019-2805

Conference paper

Liu Y-H, Tan KAL, Morrison IW, Lamb JR, Argyle DJet al., 2013, Macrophage migration is controlled by Tribbles 1 through the interaction between C/EBP beta and TNF-alpha, VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, Vol: 155, Pages: 67-75, ISSN: 0165-2427

Journal article

Peng J, Tsang JYS, Li D, Niu N, Ho DHH, Lau KF, Lui VCH, Lamb JR, Chen Y, Tam PKHet al., 2013, Inhibition of TGF-beta signaling in combination with TLR7 ligation re-programs a tumoricidal phenotype in tumor-associated macrophages, CANCER LETTERS, Vol: 331, Pages: 239-249, ISSN: 0304-3835

Journal article

Chen L, McGinty J, Taylor HB, Bugeon L, Lamb JR, Dallman MJ, French Pet al., 2012, Improved OPT reconstructions based on the MTF and extension to FLIM-OPT

We demonstrate the improved reconstruction of OPT datasets by incorporating the measured MTF in the reconstruction process. We also extend OPT to FLIM-OPT and demonstrate its use for imaging live zebrafish embryos displaying autofluorescence. © 2012 OSA.

Conference paper

Taylor HB, Liepe J, Barthen C, Bugeon L, Huvet M, Kirk PDW, Brown SB, Lamb JR, Stumpf MPH, Dallman MJet al., 2012, P38 and JNK have opposing effects on persistence of in vivo leukocyte migration in zebrafish, Immunology and Cell Biology, Vol: 91, Pages: 60-69, ISSN: 1440-1711

The recruitment and migration of macrophages and neutrophils is an important process during the early stages of the innate immune system in response to acute injury. Transgenic pu.1:EGFP zebrafish permit the acquisition of leukocyte migration trajectories during inflammation. Currently, these high-quality live-imaging data are mainly analysed using general statistics, for example, cell velocity. Here, we present a spatio-temporal analysis of the cell dynamics using transition matrices, which provide information of the type of cell migration. We find evidence that leukocytes exhibit types of migratory behaviour, which differ from previously described random walk processes. Dimethyl sulfoxide treatment decreased the level of persistence at early time points after wounding and ablated temporal dependencies observed in untreated embryos. We then use pharmacological inhibition of p38 and c-Jun N-terminal kinase mitogen-activated protein kinases to determine their effects on in vivo leukocyte migration patterns and discuss how they modify the characteristics of the cell migration process. In particular, we find that their respective inhibition leads to decreased and increased levels of persistent motion in leukocytes following wounding. This example shows the high level of information content, which can be gained from live-imaging data if appropriate statistical tools are used.

Journal article

Progatzky F, Taylor H, Bugeon L, Cassidy S, Radbruch A, Dallman MJ, Lamb JRet al., 2012, The role of Nfil3 in zebrafish hematopoiesis, DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, Vol: 38, Pages: 187-192, ISSN: 0145-305X

Journal article

Peng J, Li D, Chan YK, Chen Y, Lamb JR, Tam PKH, El-Nezami Het al., 2012, Effects of water uptake on melamine renal stone formation in mice, NEPHROLOGY DIALYSIS TRANSPLANTATION, Vol: 27, Pages: 2225-2231, ISSN: 0931-0509

Journal article

Chen L, McGinty J, Taylor HB, Bugeon L, Lamb JR, Dallman MJ, French PMWet al., 2012, Incorporation of an experimentally determined MTF for spatial frequency filtering and deconvolution during optical projection tomography reconstruction, OPTICS EXPRESS, Vol: 20, Pages: 7323-7337, ISSN: 1094-4087

Journal article

Liepe J, Taylor H, Barnes CP, Huvet M, Bugeon L, Thorne T, Lamb JR, Dallman MJ, Stumpf MPHet al., 2012, Calibrating spatio-temporal models of leukocyte dynamics against in vivo live-imaging data using approximate Bayesian computation, INTEGRATIVE BIOLOGY, Vol: 4, Pages: 335-345, ISSN: 1757-9694

Journal article

Weller CL, Collington SJ, Williams T, Lamb JRet al., 2011, Mast cells in health and disease, CLINICAL SCIENCE, Vol: 120, Pages: 473-484, ISSN: 0143-5221

Journal article

Chen Y, Li D, Tsang JYS, Niu N, Peng J, Zhu J, Hui K, Xu A, Lui VCH, Lamb JR, Tam PKHet al., 2011, PPAR-gamma signaling and IL-5 inhibition together prevent chronic rejection of MHC Class II mismatched cardiac grafts, JOURNAL OF HEART AND LUNG TRANSPLANTATION, Vol: 30, Pages: 698-706, ISSN: 1053-2498

Journal article

Pridgeon C, Bugeon L, Donnelly L, Straschil U, Tudhope SJ, Fenwick P, Lamb JR, Barnes PJ, Dallman MJet al., 2011, Regulation of IL-17 in chronic inflammation in the human lung., Clin Sci (Lond), Vol: 120, Pages: 515-524

The regulation of human Th17 cell effector function by Treg cells (regulatory T-cells) is poorly understood. In the present study, we report that human Treg (CD4(+)CD25(+)) cells inhibit the proliferative response of Th17 cells but not their capacity to secrete IL (interleukin)-17. However, they could inhibit proliferation and cytokine production by Th1 and Th2 cells as determined by IFN-γ (interferon-γ) and IL-5 biosynthesis. Currently, as there is interest in the role of IL-17-producing cells and Treg cells in chronic inflammatory diseases in humans, we investigated the presence of CD4(+)CD25(+) T-cells and IL-17 in inflammation in the human lung. Transcripts for IL-17 were expressed in mononuclear cells and purified T-cells from lung tissue of patients with chronic pulmonary inflammation and, when activated, these cells secrete soluble protein. The T-cell-specific transcription factors RORCv2 (retinoic acid-related orphan receptor Cv2; for Th17) and FOXP3 (forkhead box P3; for Treg cells) were enriched in the T-cell fraction of lung mononuclear cells. Retrospective stratification of the patient cohort into those with COPD (chronic obstructive pulmonary disease) and non-COPD lung disease revealed no difference in the expression of IL-17 and IL-23 receptor between the groups. We observed that CD4(+)CD25(+) T-cells were present in comparable numbers in COPD and non-COPD lung tissue and with no correlation between the presence of CD4(+)CD25(+) T-cells and IL-17-producing cells. These results suggest that IL-17-expressing cells are present in chronically inflamed lung tissue, but there is no evidence to support this is due to the recruitment or expansion of Treg cells.

Journal article

McGinty J, Taylor HB, Chen L, Bugeon L, Lamb JR, Dallman MJ, French PMWet al., 2011, In vivo fluorescence lifetime optical projection tomography, Biomedical Optics Express, Vol: 2, Pages: 1340-1350, ISSN: 2156-7085

We demonstrate the application of fluorescence lifetime optical projection tomography (FLIM-OPT) to in vivo imaging of lysC:GFP transgenic zebrafish embryos (Danio rerio). This method has been applied to unambiguously distinguish between the fluorescent protein (GFP) signal in myeloid cells from background autofluorescence based on the fluorescence lifetime. The combination of FLIM, an inherently ratiometric method, in conjunction with OPT results in a quantitative 3-D tomographic technique that could be used as a robust method for in vivo biological and pharmaceutical research, for example as a readout of Förster resonance energy transfer based interactions.

Journal article

Urbanowicz RA, Lamb JR, Todd I, Corne JM, Fairclough LCet al., 2010, Enhanced effector function of cytotoxic cells in the induced sputum of COPD patients, RESPIRATORY RESEARCH, Vol: 11, ISSN: 1465-993X

Journal article

Urbanowicz RA, Lamb JR, Todd I, Corne JM, Fairclough LCet al., 2009, Altered effector function of peripheral cytotoxic cells in COPD, RESPIRATORY RESEARCH, Vol: 10, ISSN: 1465-993X

Journal article

Lockhart A, Lamb JR, Osredkar T, Sue LI, Joyce JN, Ye L, Libri V, Leppert D, Beach TGet al., 2007, PIB is a non-specific imaging marker of amyloid-beta (A beta) peptide-related cerebral amyloidosis, BRAIN, Vol: 130, Pages: 2607-2615, ISSN: 0006-8950

Journal article

Chen Y, Liu Y, Yuan Z, Tian L, Dallman MJ, Thompson PW, Tam PKH, Lamb JRet al., 2007, Rosiglitazone suppresses cyclosporin-induced chronic transplant dysfunction and prolongs survival of rat cardiac allografts, TRANSPLANTATION, Vol: 83, Pages: 1602-1610, ISSN: 0041-1337

Journal article

Chen Y, Li X, Tian L, Lui VCH, Dallman MJ, Lamb JR, Tam PKHet al., 2007, Inhibition of sonic hedgehog signaling reduces chronic rejection and prolongs allograft survival in a rat orthotopic small bowel transplantation model, TRANSPLANTATION, Vol: 83, Pages: 1351-1357, ISSN: 0041-1337

Journal article

Carlin LM, Yanagi K, Verhoef A, Hoen ENMN, Yates J, Gardner L, Lamb J, Lombardi G, Dallman MJ, Davis DMet al., 2005, Secretion of IFN-gamma and not IL-2 by anergic human T cells correlates with assembly of an immature immune synapse, BLOOD, Vol: 106, Pages: 3874-3879, ISSN: 0006-4971

Journal article

Dallman MJ, Smith E, Benson RA, Lamb JRet al., 2005, Notch: Control of lymphocyte differentiation in the periphery, CURRENT OPINION IN IMMUNOLOGY, Vol: 17, Pages: 259-266, ISSN: 0952-7915

Journal article

Wong KK, Carpenter M, Young LL, Walker SJ, McKenzie G, Rust A, Ward G, Packwood L, Wahl K, Delriviere L, Hoyne G, Gibbs P, Champion BR, Lamb JR, Dallman MJet al., 2003, Notch ligation by Delta1 inhibits peripheral immune responses to transplantation antigens by a CD8(+) cell-dependent mechanism, JOURNAL OF CLINICAL INVESTIGATION, Vol: 112, Pages: 1741-1750, ISSN: 0021-9738

Journal article

Faith A, Richards DF, Verhoef A, Lamb JR, Lee TH, Hawrylowicz CMet al., 2003, Impaired secretion of interleukin-4 and interleukin-13 by allergen-specific T cells correlates with defective nuclear expression of NF-AT2 and jun B: relevance to immunotherapy, CLINICAL AND EXPERIMENTAL ALLERGY, Vol: 33, Pages: 1209-1215, ISSN: 0954-7894

Journal article

Mckenzie GJ, Young LL, Briend E, Lamb JR, Dallman MJ, Champion BRet al., 2003, Notch signalling in the regulation of peripheral T-cell function, SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, Vol: 14, Pages: 127-134, ISSN: 1084-9521

Journal article

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