Imperial College London

Dr Jonathan Underwood

Faculty of MedicineDepartment of Medicine

Honorary Clinical Research Fellow
 
 
 
//

Contact

 

+44 (0)20 3312 1466jonathan.underwood Website CV

 
 
//

Location

 

Winston Churchill WingSt Mary's Campus

//

Summary

 

Publications

Publication Type
Year
to

40 results found

Dhillon S, Sabin CA, Alagaratnam J, Bagkeris E, Post FA, Boffito M, Anderson J, Vera J, Williams I, Johnson M, Sachikonye M, Babalis D, Mallon PW, Winston A, Ndoutoumou A, Post F, Asboe D, Garvey L, Pozniak A, Clarke A, Bexley A, Richardson C, Kirk S, Gleig R, Bracchi M, Pagani N, Cerrone M, Bradshaw D, Ferretti F, Higgs C, Seah E, Fletcher S, Anthonipillai M, Moyes A, Deats K, Syed I, Matthews C, Fernando P, Chiwome C, Hardwick S, Anderson J, Mguni S, Clark R, Nevin-Dolan R, Pelluri S, Campbell L, Yurdakul S, Okumu S, Pollard L, Santana-Suarez B, Mallon P, Macken A, Ghavani-Kia B, Maher J, Byrne M, Flaherty A, Babu S, Williams I, Otiko D, Phillips L, Laverick R, Beynon M, Salz A-L, Severn A, Winston A, Garvey L, Underwood J, Tembo L, Stott M, McDonald L, Dransfield F, Whitehouse A, Burgess L, Babalis D, Johnson M, Ngwu N, Hemat N, Jones M, Carroll A, Kinloch S, Youle M, Madge S, Sabin C, De Francesco D, Bagkeris Eet al., 2019, Level of agreement between frequently used cardiovascular risk calculators in people living with HIV, HIV MEDICINE, Vol: 20, Pages: 347-352, ISSN: 1464-2662

JOURNAL ARTICLE

Underwood J, de francesco D, Cole JH, Caan MWA, Van Zoest RA, Schmand BA, Sharp D, Sabin CA, Reiss P, Winston Aet al., Validation of a novel multivariate method of defining HIV-associated cognitive impairment, Open Forum Infectious Diseases, ISSN: 2328-8957

JOURNAL ARTICLE

Underwood J, De Francesco D, Cole J, Wit F, Sharp D, Sabin C, Reiss P, Winston Aet al., 2019, Antiretroviral central nervous system toxicity, British HIV Association, Publisher: WILEY, Pages: 36-36, ISSN: 1464-2662

CONFERENCE PAPER

De Francesco D, Winston A, Underwood J, Cresswell FV, Anderson J, Post FA, Williams I, Mallon PWG, Sachikonye M, Babalis D, Vera JH, Bagkeris E, Milinkovic A, Sabin CA, Babalis D, Boffito M, Burgess L, Mallon P, Post FA, Sabin CA, Sachikonye M, Winston A, Anderson J, Asboe D, Boffito M, Garvey L, Mallon P, Post FA, Pozniak A, Sabin CA, Sachikonye M, Vera JH, Williams I, Winston A, Clarke A, Vera JH, Bexley A, Richardson C, Kirk S, Gleig R, Boffito M, Asboe D, Pozniak A, Bracchi M, Pagani N, Cerrone M, Bradshaw D, Ferretti F, Higgs C, Seah E, Fletcher S, Anthonipillai M, Moyes A, Deats K, Syed I, Matthews C, Fernando P, Chiwome C, Hardwick S, Anderson J, Mguni S, Clark R, Nevin-Dolan R, Pelluri S, Post FA, Campbell L, Yurdakul S, Okumu S, Pollard L, Santana-Suarez B, Mallon P, Macken A, Ghavani-Kia B, Maher J, Byrne M, Flaherty A, Babu S, Williams I, Otiko D, Phillips L, Laverick R, Beynon M, Salz A-L, Severn A, Winston A, Garvey L, Underwood J, Tembo L, Stott M, McDonald L, Dransfield F, Whitehouse A, Burgess L, Babalis D, Johnson M, Ngwu N, Hemat N, Jones M, Carroll A, Kinloch S, Youle M, Madge S, Sabin CA, De Francesco D, Bagkeris Eet al., 2019, Cognitive function, depressive symptoms and syphilis in HIV-positive and HIV-negative individuals, INTERNATIONAL JOURNAL OF STD & AIDS, Vol: 30, Pages: 440-446, ISSN: 0956-4624

JOURNAL ARTICLE

De Francesco D, Underwood J, Bagkeris E, Boffito M, Post FA, Mallon PWG, Vera JH, Williams I, Anderson J, Johnson M, Sabin CA, Winston A, Babalis D, Boffito M, Burgess L, Mallon P, Sabin C, Sachikonye M, Winston A, Asboe D, Garvey L, Pozniak A, Sabin C, Sachikonye M, Clarke A, Vera J, Bexley A, Richardson C, Kirk S, Gleig R, Asboe D, Pozniak A, Bracchi M, Pagani N, Cerrone M, Bradshaw D, Ferretti F, Higgs C, Seah E, Fletcher S, Anthonipillai M, Moyes A, Deats K, Syed I, Matthews C, Fernando P, Chiwome C, Hardwick S, Anderson J, Mguni S, Clark R, Nevin-Dolan R, Pelluri S, Post F, Campbell L, Yurdakul S, Okumu S, Pollard L, Santana-Suarez B, Macken A, Ghavani-Kia B, Maher J, Byrne M, Flaherty A, Babu S, Otiko D, Phillips L, Laverick R, Beynon M, Salz A-L, Severn A, Winston A, Garvey L, Tembo L, Stott M, McDonald L, Dransfield F, Whitehouse A, Burgess L, Babalis D, Ngwu N, Hemat N, Jones M, Carroll A, Kinloch S, Youle M, Madge S, Sabin Cet al., 2019, Depression, lifestyle factors and cognitive function in people living with HIV and comparable HIV-negative controls, HIV MEDICINE, Vol: 20, Pages: 274-285, ISSN: 1464-2662

JOURNAL ARTICLE

De Francesco D, Wit FW, Burkle A, Oehlke S, Kootstra NA, Winston A, Franceschi C, Garagnani P, Pirazzini C, Libert C, Grune T, Weber D, Jansen EHJM, Sabin CA, Reiss P, Reiss P, Winston A, Wit FW, Prins M, van der Loeff MFS, Schouten J, Schmand B, Geurtsen GJ, Sharp DJ, Caan MWA, Majoie C, Villaudy J, Berkhout B, Kootstra NA, Gisslen M, Pasternak A, Sabin CA, Guaraldi G, Burkle A, Libert C, Franceschi C, Kalsbeek A, Fliers E, Hoeijmakers J, Pothof J, van der Valk M, Bisschop PH, Portegies P, Zaheri S, Burger D, Cole JH, Biirkle A, Zikkenheiner W, Janssen FR, Underwood J, Kooij KW, van Zoest RA, Doyle N, van der Loeff MS, Schmand BA, Verheij E, Verboeket SO, Elsenga BC, Hillebregt MMJ, Ruijs YMC, Benschop DP, Tembo L, McDonald L, Stott M, Legg K, Lovell A, Erlwein O, Kingsley C, Norsworthy P, Mullaney S, Kruijer T, del Grande L, Olthof V, Visser GR, May L, Verbraak F, Demirkaya N, Visser I, Majoie CBLM, Su T, Leech R, Huguet J, Frankin E, van der Kuyl A, Weijer K, Siteur-Van Rijnstra E, Harskamp-Holwerda AM, Maurer I, Ruiz MMM, Girigorie AF, Boeser-Nunnink B, Kals-Beek A, Bisschop PHLT, de Graaff-Teulen M, Dewaele S, Garagnani P, Pirazzini C, Capri M, Dall'Olio F, Chiricolo M, Salvioli S, Fuchs D, Zetterberg H, Weber D, Grune T, Jansen EHJM, De Francesco D, Sindlinger T, Oehlke Set al., 2019, Do people living with HIV experience greater age advancement than their HIV-negative counterparts?, AIDS, Vol: 33, Pages: 259-268, ISSN: 0269-9370

JOURNAL ARTICLE

Pool ERM, Winston A, Bagkeris E, Vera JH, Mallon PWG, Sachikonye M, Post FA, Pozniak A, Boffito M, Anderson J, Williams I, Johnson M, Burgess L, Sabin CAet al., 2019, High-risk behaviours, and their associations with mental health, adherence to antiretroviral therapy and HIV parameters, in HIV-positive men who have sex with men, HIV MEDICINE, Vol: 20, Pages: 131-136, ISSN: 1464-2662

JOURNAL ARTICLE

De Francesco D, Verboeket SO, Underwood J, Bagkeris E, Wit FW, Mallon PWG, Winston A, Reiss P, Sabin CA, Babalis D, Boffito M, Burgess L, Mallon P, Post F, Sachikonye M, Anderson J, Asboe D, Garvey L, Pozniak A, Vera J, Williams I, Clarke A, Bexley A, Richardson C, Kirk S, Gleig R, Bracchi M, Pagani N, Cerrone M, Bradshaw D, Ferretti F, Higgs C, Seah E, Fletcher S, Anthonipillai M, Moyes A, Deats K, Syed I, Matthews C, Fernando P, Chiwome C, Hardwick S, Mguni S, Clark R, Nevin-Dolan R, Pelluri S, Campbell L, Yurdakul S, Okumu S, Pollard L, Santana-Suarez B, Macken A, Ghavani-Kia B, Maher J, Byrne M, Flaherty A, Babu S, Otiko D, Phillips L, Laverick R, Beynon M, Salz A-L, Severn A, Tembo L, Stott M, McDonald L, Dransfield F, Whitehouse A, Johnson M, Ngwu N, Hemat N, Jones M, Carroll A, Kinloch S, Youle M, Madge S, Reiss P, Wit FWNM, van der Valk M, Schouten J, Kooij KW, van Zoest RA, Verheij E, Elsenga BC, Prins M, van der Loeff MFS, del Grande L, Olthof V, Dijkstra M, Zaheri S, Hillebregt MMJ, Ruijs YMC, Benschop DP, el Berkaoui A, Kootstra NA, Harskamp-Holwerda AM, Maurer I, Ruiz MMM, Girigorie AF, Boeser-Nunnink B, Zikkenheiner W, Janssen FR, Geerlings SE, Goorhuis A, Hovius JWR, Nellen FJB, van der Poll T, Prins JM, Wiersinga WJ, van Vugt M, de Bree G, van Eden J, van Hes AMH, Pijnappel FJJ, Weijsenfeld A, Smalhout S, van Duinen M, Hazenberg A, Postema PG, Bisschop PHLT, Serlie MJM, Lips P, Dekker E, van der Velde N, Willemsen JMR, Vogt L, Portegies P, Schmand BA, Geurtsen GJ, Verbraak FD, Demirkaya N, Visser I, Schade A, Nieuwkerk PT, Langebeek N, van Steenwijk RP, Dijkers E, Majoie CBLM, Caan MWA, van Lunsen HW, Nievaard MAF, van den Born BJH, Stroes ESG, Mulder WMC, van Oorspronk Set al., 2018, Patterns of Co-occurring Comorbidities in People Living With HIV, OPEN FORUM INFECTIOUS DISEASES, Vol: 5, ISSN: 2328-8957

JOURNAL ARTICLE

Underwood J, Cole JH, Leech R, Sharp DJ, Winston Aet al., 2018, Multivariate Pattern Analysis of Volumetric Neuroimaging Data and Its Relationship With Cognitive Function in Treated HIV Disease, JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, Vol: 78, Pages: 429-436, ISSN: 1525-4135

JOURNAL ARTICLE

Cole JH, Caan MWA, Underwood J, De Francesco D, van Zoest RA, Wit FWNM, Mutsaerts HJMM, Leech R, Geurtsen GJ, Portegies P, Majoie CBLM, van der Loeff MFS, Sabin CA, Reiss P, Winston A, Sharp DJet al., 2018, No Evidence for Accelerated Aging-Related Brain Pathology in Treated Human Immunodeficiency Virus: Longitudinal Neuroimaging Results From the Comorbidity in Relation to AIDS (COBRA) Project, CLINICAL INFECTIOUS DISEASES, Vol: 66, Pages: 1899-1909, ISSN: 1058-4838

JOURNAL ARTICLE

Underwood J, De Francesco D, Leech R, Sabine CA, Winston Aet al., 2018, Medicalising normality? Using a simulated dataset to assess the performance of different diagnostic criteria of HIV-associated cognitive impairment, PLOS ONE, Vol: 13, ISSN: 1932-6203

JOURNAL ARTICLE

Francesco DD, Underwood J, Vera JH, Bagkeris E, Asboe D, Mallon PWG, Post FA, Johnson M, Williams I, Boffito M, Greliak P, Anderson J, Sabin CA, Winston Aet al., 2018, Associations between cognitive function and cardiovascular risk factors: differences between people with HIV and HIV-negative controls, Publisher: WILEY, Pages: S10-S11, ISSN: 1464-2662

CONFERENCE PAPER

De Francesco D, Winston A, Choi JY, van Zoest RA, Underwood J, Schouten J, Ku NS, Kim WJ, Reiss P, Sabin CAet al., 2018, Determinants of cognitive function differ in a European and a Korean cohort, Publisher: WILEY, Pages: S75-S75, ISSN: 1464-2662

CONFERENCE PAPER

De Francesco D, Wit FW, Cole JH, Kootstra NA, Winston A, Sabin CA, Underwood J, van Zoest RA, Schouten J, Kooij KW, Prins M, Guaraldi G, Caan MWA, Burger D, Franceschi C, Libert C, Buerkie A, Reiss Pet al., 2018, The 'COmorBidity in Relation to AIDS' (COBRA) cohort: Design, methods and participant characteristics, PLOS ONE, Vol: 13, ISSN: 1932-6203

JOURNAL ARTICLE

van Zoest RA, Underwood J, De Francesco D, Sabin CA, Cole JH, Wit FW, Caan MWA, Kootstra NA, Fuchs D, Zetterberg H, Majoie CBLM, Portegies P, Winston A, Sharp DJ, Gisslen M, Reiss Pet al., 2018, Structural Brain Abnormalities in Successfully Treated HIV Infection: Associations With Disease and Cerebrospinal Fluid Biomarkers, JOURNAL OF INFECTIOUS DISEASES, Vol: 217, Pages: 69-81, ISSN: 0022-1899

JOURNAL ARTICLE

Ferretti F, Mora-Peris B, Underwood J, Waldman A, Everitt A, Winston Aet al., 2018, Cognitive Impairment in a Clinical Setting., J Acquir Immune Defic Syndr, Vol: 77, Pages: e10-e13

JOURNAL ARTICLE

Ferretti F, Mora-Peris B, Underwood J, Waldman A, Everitt A, Winston Aet al., 2018, Cognitive Impairment in a Clinical Setting, JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, Vol: 77, Pages: E10-E13, ISSN: 1525-4135

JOURNAL ARTICLE

Underwood J, Cole JH, Caan M, De Francesco D, Leech R, van Zoest RA, Su T, Geurtsen GJ, Schmand BA, Portegies P, Prins M, Wit FWNM, Sabin CA, Majoie C, Reiss P, Winston A, Sharp DJet al., 2017, Gray and White Matter Abnormalities in Treated Human Immunodeficiency Virus Disease and Their Relationship to Cognitive Function, CLINICAL INFECTIOUS DISEASES, Vol: 65, Pages: 422-432, ISSN: 1058-4838

JOURNAL ARTICLE

Booiman T, Wit FW, Maurer I, De Francesco D, Sabin CA, Harskamp AM, Prins M, Garagnani P, Pirazzini C, Franceschi C, Fuchs D, Gisslen M, Winston A, Reiss P, Kootstra NAet al., 2017, High Cellular Monocyte Activation in People Living With Human Immunodeficiency Virus on Combination Antiretroviral Therapy and Lifestyle-Matched Controls Is Associated With Greater Inflammation in Cerebrospinal Fluid, OPEN FORUM INFECTIOUS DISEASES, Vol: 4, ISSN: 2328-8957

JOURNAL ARTICLE

Underwood J, Cresswell F, Salam AP, Keeley AJ, Cleland C, John L, Davidson RNet al., 2017, Complications of miliary tuberculosis: low mortality and predictive biomarkers from a UK cohort, BMC INFECTIOUS DISEASES, Vol: 17, ISSN: 1471-2334

JOURNAL ARTICLE

Cole JH, Underwood J, Caan MWA, De Francesco D, van Zoest RA, Leech R, Wit FWNM, Portegies P, Geurtsen GJ, Schmand BA, van der Loeff MFS, Franceschi C, Sabin CA, Majoie CBLM, Winston A, Reiss P, Sharp DJet al., 2017, Increased brain-predicted aging in treated HIV disease, NEUROLOGY, Vol: 88, Pages: 1349-1357, ISSN: 0028-3878

JOURNAL ARTICLE

Chhabra S, Underwood J, Cole JH, Waldman A, Sharp DJ, Winston A, Sabin Cet al., 2017, Clinical research cerebral MRI findings in HIV positive subjects and appropriate controls, BHIVA annual conference, Publisher: WILEY, Pages: 10-10, ISSN: 1464-2662

CONFERENCE PAPER

Underwood J, Leech R, Winston A, Sabin C, De Francesco Det al., 2017, Medicalising normality? Using a simulated dataset to assess the performance of different diagnostic criteria of cognitive impairment, Publisher: WILEY, Pages: 40-41, ISSN: 1464-2662

CONFERENCE PAPER

Yilmaz A, Blennow K, Hagberg L, Nilsson S, Price RW, Schouten J, Spudich S, Underwood J, Zetterberg H, Gisslen Met al., 2017, Neurofilament light chain protein as a marker of neuronal injury: review of its use in HIV-1 infection and reference values for HIV-negative controls, EXPERT REVIEW OF MOLECULAR DIAGNOSTICS, Vol: 17, Pages: 761-770, ISSN: 1473-7159

JOURNAL ARTICLE

De Francesco D, Underwood J, Post FA, Vera JH, Williams I, Boffito M, Sachikonye M, Anderson J, Mallon PWG, Winston A, Sabin CAet al., 2016, Defining cognitive impairment in people-living-with-HIV: the POPPY study, BMC INFECTIOUS DISEASES, Vol: 16, ISSN: 1471-2334

JOURNAL ARTICLE

Underwood J, De Francesco D, Post FA, Vera JH, Williams I, Boffito M, Mallon PW, Anderson J, Sachikonye M, Sabin C, Winston A, Pharmacokinetic and Clinical Observations in People Over Fifty POPPY study groupet al., 2016, Associations between cognitive impairment and patient-reported measures of physical/mental functioning in older people living with HIV, HIV Medicine, Vol: 18, Pages: 363-369, ISSN: 1464-2662

OBJECTIVES: While cognitive impairment is frequently reported in HIV-positive individuals and has historically been associated with poorer functional outcomes, the associations between cognitive impairment and patient-reported outcome measures (PROMs) in contemporary cohorts are unclear. METHODS: We tested cognitive function using a computerized battery (CogState(™) ) in 290 HIV-positive and 97 HIV-negative individuals aged ≥ 50 years participating in the Pharmacokinetic and Clinical Observations in People Over Fifty (POPPY) study. Participants completed questionnaires detailing physical and mental health [Short Form Health Survey (SF-36)], cognitive function [European AIDS Clinical Society (EACS) questions], activities of daily living [Lawton Instrumental Activities of Daily Living (IADL)], depression [Patient Depression Questionnaire (PHQ-9) and Centres for Epidemiologic Studies Depression scale (CES-D)], falls and sexual desire. Cognitive impairment was defined using the Frascati criteria, global deficit score (GDS) and multivariate normative comparison (MNC). In the HIV-positive group, the classification performances of the different definitions of cognitive impairment and dichotomized questionnaire results were calculated. RESULTS: The prevalence of cognitive impairment in the HIV-positive group was 34.5% (GDS), 30.0% (Frascati) and 22.1% (MNC), with only 2% diagnosed with HIV-associated dementia. In general, the associations between cognitive impairment and PROMs were weak regardless of the definition used: mean c-statistics were 0.543 (GDS), 0.530 (MNC) and 0.519 (Frascati). Associations were similar using the global T-score to define cognitive impairment. Summary health scores (SF-36) were lower, but only significantly so for those with cognitive impairment identified using MNC, for both mental health (61.4 vs. 75.8; P = 0.03) and physical health (60.9 vs. 75.0; P = 0.03). CONCLUSIONS: The associations between cognitive impairment and PROMs were wea

JOURNAL ARTICLE

Underwood J, Winston A, 2016, Guidelines for Evaluation and Management of Cognitive Disorders in HIV-Positive Individuals, CURRENT HIV/AIDS REPORTS, Vol: 13, Pages: 235-240, ISSN: 1548-3568

JOURNAL ARTICLE

De Francesco D, Underwood J, Boffito M, Post F, Mallon P, Vera J, Williams I, Anderson J, Johnson M, Sabin C, Winston Aet al., 2016, Cognitive function and depression in HIV-positive individuals and matched controls, JOURNAL OF THE INTERNATIONAL AIDS SOCIETY, Vol: 19, ISSN: 1758-2652

JOURNAL ARTICLE

Mora-Peris B, Stevens E, Ferretti F, Underwood J, Taylor S, Winston Aet al., 2016, Evolution of changes in cognitive function after the initiation of antiretroviral therapy, AIDS RESEARCH AND THERAPY, Vol: 13, ISSN: 1742-6405

JOURNAL ARTICLE

Thornhill J, Underwood J, Kuldanek K, Mahay K, Fidler S, Frater J, Hopkins E, Meyerowitz J, Fox J, Nwokolo N, Whitlock G, Mackie N, Porter Ket al., 2016, Impact of timing of ART on HIV DNA; findings from HEATHER, an observational cohort study, Publisher: WILEY-BLACKWELL, Pages: 11-11, ISSN: 1464-2662

CONFERENCE PAPER

This data is extracted from the Web of Science and reproduced under a licence from Thomson Reuters. You may not copy or re-distribute this data in whole or in part without the written consent of the Science business of Thomson Reuters.

Request URL: http://wlsprd.imperial.ac.uk:80/respub/WEB-INF/jsp/search-html.jsp Request URI: /respub/WEB-INF/jsp/search-html.jsp Query String: limit=30&amp%3bid=00239388&amp%3brespub-action=search.html&amp%3bperson=true&amp%3bpage=2&respub-action=search.html&id=00239388&person=true