Imperial College London

Dr Jonathan Underwood

Faculty of MedicineDepartment of Infectious Disease

Honorary Clinical Research Fellow



+44 (0)20 3312 1466jonathan.underwood Website CV




Winston Churchill WingSt Mary's Campus






BibTex format

author = {De, Francesco D and Wit, FW and Burkle, A and Oehlke, S and Kootstra, NA and Winston, A and Franceschi, C and Garagnani, P and Pirazzini, C and Libert, C and Grune, T and Weber, D and Jansen, EHJM and Sabin, CA and Reiss, P and Reiss, P and Winston, A and Wit, FW and Prins, M and van, der Loeff MFS and Schouten, J and Schmand, B and Geurtsen, GJ and Sharp, DJ and Caan, MWA and Majoie, C and Villaudy, J and Berkhout, B and Kootstra, NA and Gisslen, M and Pasternak, A and Sabin, CA and Guaraldi, G and Burkle, A and Libert, C and Franceschi, C and Kalsbeek, A and Fliers, E and Hoeijmakers, J and Pothof, J and van, der Valk M and Bisschop, PH and Portegies, P and Zaheri, S and Burger, D and Cole, JH and Biirkle, A and Zikkenheiner, W and Janssen, FR and Underwood, J and Kooij, KW and van, Zoest RA and Doyle, N and van, der Loeff MS and Schmand, BA and Verheij, E and Verboeket, SO and Elsenga, BC and Hillebregt, MMJ and Ruijs, YMC and Benschop, DP and Tembo, L and McDonald, L and Stott, M a},
doi = {10.1097/QAD.0000000000002063},
journal = {AIDS},
pages = {259--268},
title = {Do people living with HIV experience greater age advancement than their HIV-negative counterparts?},
url = {},
volume = {33},
year = {2019}

RIS format (EndNote, RefMan)

AB - Objectives: Despite successful antiretroviral therapy, people living with HIV (PLWH)may show signs of premature/accentuated aging. We compared established biomarkersof aging in PLWH, appropriately chosen HIV-negative individuals, and blood donors,and explored factors associated with biological age advancement.Design: Cross-sectional analysis of 134 PLWH on suppressive antiretroviral therapy, 79lifestyle-comparable HIV-negative controls aged 45 years or older from the Co-morBidity in Relation to AIDS (COBRA) cohort, and 35 age-matched blood donors.Methods: Biological age was estimated using a validated algorithm based on 10biomarkers. Associations between ‘age advancement’ (biological minus chronological age) and HIV status/parameters, lifestyle, cytomegalovirus (CMV), hepatitisB (HBV) and hepatitis C virus (HCV) infections were investigated using linear regression.Results: The average (95% CI) age advancement was greater in both HIV-positive [13.2(11.6–14.9) years] and HIV-negative [5.5 (3.8–7.2) years] COBRA participants comparedwith blood donors [7.0 (4.1 to 9.9) years, both P’s< 0.001)], but also in HIV-positivecompared with HIV-negative participants (P < 0.001). Chronic HBV, higher anti-CMVIgG titer and CD8þ T-cell count were each associated with increased age advancement, independently of HIV-status/group. Among HIV-positive participants, ageadvancement was increased by 3.5 (0.1–6.8) years among those with nadir CD4þT-cell count less than 200 cells/ml and by 0.1 (0.06–0.2) years for each additionalmonth of exposure to saquinavir.
AU - De,Francesco D
AU - Wit,FW
AU - Burkle,A
AU - Oehlke,S
AU - Kootstra,NA
AU - Winston,A
AU - Franceschi,C
AU - Garagnani,P
AU - Pirazzini,C
AU - Libert,C
AU - Grune,T
AU - Weber,D
AU - Jansen,EHJM
AU - Sabin,CA
AU - Reiss,P
AU - Reiss,P
AU - Winston,A
AU - Wit,FW
AU - Prins,M
AU - van,der Loeff MFS
AU - Schouten,J
AU - Schmand,B
AU - Geurtsen,GJ
AU - Sharp,DJ
AU - Caan,MWA
AU - Majoie,C
AU - Villaudy,J
AU - Berkhout,B
AU - Kootstra,NA
AU - Gisslen,M
AU - Pasternak,A
AU - Sabin,CA
AU - Guaraldi,G
AU - Burkle,A
AU - Libert,C
AU - Franceschi,C
AU - Kalsbeek,A
AU - Fliers,E
AU - Hoeijmakers,J
AU - Pothof,J
AU - van,der Valk M
AU - Bisschop,PH
AU - Portegies,P
AU - Zaheri,S
AU - Burger,D
AU - Cole,JH
AU - Biirkle,A
AU - Zikkenheiner,W
AU - Janssen,FR
AU - Underwood,J
AU - Kooij,KW
AU - van,Zoest RA
AU - Doyle,N
AU - van,der Loeff MS
AU - Schmand,BA
AU - Verheij,E
AU - Verboeket,SO
AU - Elsenga,BC
AU - Hillebregt,MMJ
AU - Ruijs,YMC
AU - Benschop,DP
AU - Tembo,L
AU - McDonald,L
AU - Stott,M
AU - Legg,K
AU - Lovell,A
AU - Erlwein,O
AU - Kingsley,C
AU - Norsworthy,P
AU - Mullaney,S
AU - Kruijer,T
AU - del,Grande L
AU - Olthof,V
AU - Visser,GR
AU - May,L
AU - Verbraak,F
AU - Demirkaya,N
AU - Visser,I
AU - Majoie,CBLM
AU - Su,T
AU - Leech,R
AU - Huguet,J
AU - Frankin,E
AU - van,der Kuyl A
AU - Weijer,K
AU - Siteur-Van,Rijnstra E
AU - Harskamp-Holwerda,AM
AU - Maurer,I
AU - Ruiz,MMM
AU - Girigorie,AF
AU - Boeser-Nunnink,B
AU - Kals-Beek,A
AU - Bisschop,PHLT
AU - de,Graaff-Teulen M
AU - Dewaele,S
AU - Garagnani,P
AU - Pirazzini,C
AU - Capri,M
AU - Dall'Olio,F
AU - Chiricolo,M
AU - Salvioli,S
AU - Fuchs,D
AU - Zetterberg,H
AU - Weber,D
AU - Grune,T
AU - Jansen,EHJM
AU - De,Francesco D
AU - Sindlinger,T
AU - Oehlke,S
DO - 10.1097/QAD.0000000000002063
EP - 268
PY - 2019///
SN - 0269-9370
SP - 259
TI - Do people living with HIV experience greater age advancement than their HIV-negative counterparts?
UR -
UR -
UR -
VL - 33
ER -