Imperial College London

Dr Jonathan Underwood

Faculty of MedicineDepartment of Infectious Disease

Honorary Clinical Research Fellow
 
 
 
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Contact

 

+44 (0)20 3312 1466jonathan.underwood Website CV

 
 
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Location

 

Winston Churchill WingSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Underwood:2016:10.1111/hiv.12434,
author = {Underwood, J and De, Francesco D and Post, FA and Vera, JH and Williams, I and Boffito, M and Mallon, PW and Anderson, J and Sachikonye, M and Sabin, C and Winston, A and Pharmacokinetic, and Clinical Observations in People Over Fifty POPPY study group},
doi = {10.1111/hiv.12434},
journal = {HIV Medicine},
pages = {363--369},
title = {Associations between cognitive impairment and patient-reported measures of physical/mental functioning in older people living with HIV},
url = {http://dx.doi.org/10.1111/hiv.12434},
volume = {18},
year = {2016}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - OBJECTIVES: While cognitive impairment is frequently reported in HIV-positive individuals and has historically been associated with poorer functional outcomes, the associations between cognitive impairment and patient-reported outcome measures (PROMs) in contemporary cohorts are unclear. METHODS: We tested cognitive function using a computerized battery (CogState(™) ) in 290 HIV-positive and 97 HIV-negative individuals aged ≥ 50 years participating in the Pharmacokinetic and Clinical Observations in People Over Fifty (POPPY) study. Participants completed questionnaires detailing physical and mental health [Short Form Health Survey (SF-36)], cognitive function [European AIDS Clinical Society (EACS) questions], activities of daily living [Lawton Instrumental Activities of Daily Living (IADL)], depression [Patient Depression Questionnaire (PHQ-9) and Centres for Epidemiologic Studies Depression scale (CES-D)], falls and sexual desire. Cognitive impairment was defined using the Frascati criteria, global deficit score (GDS) and multivariate normative comparison (MNC). In the HIV-positive group, the classification performances of the different definitions of cognitive impairment and dichotomized questionnaire results were calculated. RESULTS: The prevalence of cognitive impairment in the HIV-positive group was 34.5% (GDS), 30.0% (Frascati) and 22.1% (MNC), with only 2% diagnosed with HIV-associated dementia. In general, the associations between cognitive impairment and PROMs were weak regardless of the definition used: mean c-statistics were 0.543 (GDS), 0.530 (MNC) and 0.519 (Frascati). Associations were similar using the global T-score to define cognitive impairment. Summary health scores (SF-36) were lower, but only significantly so for those with cognitive impairment identified using MNC, for both mental health (61.4 vs. 75.8; P = 0.03) and physical health (60.9 vs. 75.0; P = 0.03). CONCLUSIONS: The associations between cognitive impairment and PROMs were wea
AU - Underwood,J
AU - De,Francesco D
AU - Post,FA
AU - Vera,JH
AU - Williams,I
AU - Boffito,M
AU - Mallon,PW
AU - Anderson,J
AU - Sachikonye,M
AU - Sabin,C
AU - Winston,A
AU - Pharmacokinetic,and Clinical Observations in People Over Fifty POPPY study group
DO - 10.1111/hiv.12434
EP - 369
PY - 2016///
SN - 1464-2662
SP - 363
TI - Associations between cognitive impairment and patient-reported measures of physical/mental functioning in older people living with HIV
T2 - HIV Medicine
UR - http://dx.doi.org/10.1111/hiv.12434
UR - http://www.ncbi.nlm.nih.gov/pubmed/27785907
UR - http://hdl.handle.net/10044/1/43020
VL - 18
ER -