Imperial College London

Dr Jonathan Underwood

Faculty of MedicineDepartment of Medicine

Honorary Clinical Research Fellow
 
 
 
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Contact

 

+44 (0)20 3312 1466jonathan.underwood Website CV

 
 
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Location

 

Winston Churchill WingSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Booiman:2017:ofid/ofx108,
author = {Booiman, T and Wit, FW and Maurer, I and De, Francesco D and Sabin, CA and Harskamp, AM and Prins, M and Garagnani, P and Pirazzini, C and Franceschi, C and Fuchs, D and Gisslén, M and Winston, A and Reiss, P and Kootstra, NA and Comorbidity, in Relation to AIDS COBRA Collaboration},
doi = {ofid/ofx108},
journal = {Open Forum Infectious Diseases},
title = {High Cellular Monocyte Activation in People Living With Human Immunodeficiency Virus on Combination Antiretroviral Therapy and Lifestyle-Matched Controls Is Associated With Greater Inflammation in Cerebrospinal Fluid.},
url = {http://dx.doi.org/10.1093/ofid/ofx108},
volume = {4},
year = {2017}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - BACKGROUND: Increased monocyte activation and intestinal damage have been shown to be predictive for the increased morbidity and mortality observed in treated people living with human immunodeficiency virus (PLHIV). METHODS: A cross-sectional analysis of cellular and soluble markers of monocyte activation, coagulation, intestinal damage, and inflammation in plasma and cerebrospinal fluid (CSF) of PLHIV with suppressed plasma viremia on combination antiretroviral therapy and age and demographically comparable HIV-negative individuals participating in the Comorbidity in Relation to AIDS (COBRA) cohort and, where appropriate, age-matched blood bank donors (BBD). RESULTS: People living with HIV, HIV-negative individuals, and BBD had comparable percentages of classical, intermediate, and nonclassical monocytes. Expression of CD163, CD32, CD64, HLA-DR, CD38, CD40, CD86, CD91, CD11c, and CX3CR1 on monocytes did not differ between PLHIV and HIV-negative individuals, but it differed significantly from BBD. Principal component analysis revealed that 57.5% of PLHIV and 62.5% of HIV-negative individuals had a high monocyte activation profile compared with 2.9% of BBD. Cellular monocyte activation in the COBRA cohort was strongly associated with soluble markers of monocyte activation and inflammation in the CSF. CONCLUSIONS: People living with HIV and HIV-negative COBRA participants had high levels of cellular monocyte activation compared with age-matched BBD. High monocyte activation was predictive for inflammation in the CSF.
AU - Booiman,T
AU - Wit,FW
AU - Maurer,I
AU - De,Francesco D
AU - Sabin,CA
AU - Harskamp,AM
AU - Prins,M
AU - Garagnani,P
AU - Pirazzini,C
AU - Franceschi,C
AU - Fuchs,D
AU - Gisslén,M
AU - Winston,A
AU - Reiss,P
AU - Kootstra,NA
AU - Comorbidity,in Relation to AIDS COBRA Collaboration
DO - ofid/ofx108
PY - 2017///
SN - 2328-8957
TI - High Cellular Monocyte Activation in People Living With Human Immunodeficiency Virus on Combination Antiretroviral Therapy and Lifestyle-Matched Controls Is Associated With Greater Inflammation in Cerebrospinal Fluid.
T2 - Open Forum Infectious Diseases
UR - http://dx.doi.org/10.1093/ofid/ofx108
UR - http://hdl.handle.net/10044/1/53474
VL - 4
ER -