Imperial College London

Dr Jonathan Underwood

Faculty of MedicineDepartment of Medicine

Honorary Clinical Research Fellow



+44 (0)20 3312 1466jonathan.underwood Website CV




Winston Churchill WingSt Mary's Campus






BibTex format

author = {De, Francesco D and Wit, FW and Cole, JH and Kootstra, NA and Winston, A and Sabin, CA and Underwood, J and van, Zoest RA and Schouten, J and Kooij, KW and Prins, M and Guaraldi, G and Caan, MWA and Burger, D and Franceschi, C and Libert, C and Bürkle, A and Reiss, P and COmorBidity, in Relation to AIDS COBRA collaboration},
doi = {10.1371/journal.pone.0191791},
journal = {PLoS ONE},
title = {The 'COmorBidity in Relation to AIDS' (COBRA) cohort: Design, methods and participant characteristics},
url = {},
volume = {13},
year = {2018}

RIS format (EndNote, RefMan)

AB - BACKGROUND: Persons living with HIV on combination antiretroviral therapy (cART) may be at increased risk of the development of age-associated non-communicable comorbidities (AANCC) at relatively young age. It has therefore been hypothesised that such individuals, despite effective cART, may be prone to accelerated aging. OBJECTIVE: The COmorBidity in Relation to AIDS (COBRA) cohort study was designed to investigate the potential causal link between HIV and AANCC, amongst others, in a cohort of middle-aged individuals with HIV with sustained viral suppression on cART and otherwise comparable HIV-negative controls. METHODS: Longitudinal cohort study of HIV-positive subjects ≥45 years of age, with sustained HIV suppression on cART recruited from two large European HIV treatment centres and similarly-aged HIV-negative controls recruited from sexual health centres and targeted community groups. Both HIV-positive and HIV-negative subjects were assessed at study entry and again at follow-up after 2 years. RESULTS: Of the 134 HIV-positive individuals with a median (IQR) age of 56 (51, 62) years recruited, 93% were male, 88% of white ethnicity and 86% were men who have sex with men (MSM). Similarly, the 79 HIV-negative subjects had a median (IQR) age of 57 (52, 64) and 92% were male, 97% of white ethnicity and 80% were MSM. CONCLUSIONS: The results from the COBRA study will be a significant resource to understand the link between HIV and AANCC and the pathogenic mechanisms underlying this link. COBRA will inform future development of novel prognostic tools for earlier diagnosis of AANCC and of novel interventions which, as an adjunct to cART, may prevent AANCC.
AU - De,Francesco D
AU - Wit,FW
AU - Cole,JH
AU - Kootstra,NA
AU - Winston,A
AU - Sabin,CA
AU - Underwood,J
AU - van,Zoest RA
AU - Schouten,J
AU - Kooij,KW
AU - Prins,M
AU - Guaraldi,G
AU - Caan,MWA
AU - Burger,D
AU - Franceschi,C
AU - Libert,C
AU - Bürkle,A
AU - Reiss,P
AU - COmorBidity,in Relation to AIDS COBRA collaboration
DO - 10.1371/journal.pone.0191791
PY - 2018///
SN - 1932-6203
TI - The 'COmorBidity in Relation to AIDS' (COBRA) cohort: Design, methods and participant characteristics
UR -
UR -
UR -
VL - 13
ER -