Imperial College London

Professor Joshua B. Edel

Faculty of Natural SciencesDepartment of Chemistry

Professor of Biosensing & Analytical Sciences



+44 (0)20 7594 0754joshua.edel Website




Mr John Murrell +44 (0)20 7594 2845




442AChemistrySouth Kensington Campus






BibTex format

author = {Xue, L and Cadinu, P and Paulose, Nadappuram B and Kang, M and Ma, Y and Korchev, Y and Ivanov, A and Edel, J},
doi = {10.1021/acsami.8b13721},
journal = {ACS Applied Materials and Interfaces},
pages = {38621--38629},
title = {Gated single-molecule transport in double-barreled nanopores},
url = {},
volume = {10},
year = {2018}

RIS format (EndNote, RefMan)

AB - Single-molecule methods have been rapidly developing with the appealing prospect of transforming conventional ensemble-averaged analytical techniques. However, challenges remain especially in improving detection sensitivity and controlling molecular transport. In this article, we present a direct method for the fabrication of analytical sensors that combine the advantages of nanopores and field-effect transistors for simultaneous label-free single-molecule detection and manipulation. We show that these hybrid sensors have perfectly aligned nanopores and field-effect transistor components making it possible to detect molecular events with up to near 100% synchronization. Furthermore, we show that the transport across the nanopore can be voltage-gated to switch on/off translocations in real time. Finally, surface functionalization of the gate electrode can also be used to fine tune transport properties enabling more active control over the translocation velocity and capture rates.
AU - Xue,L
AU - Cadinu,P
AU - Paulose,Nadappuram B
AU - Kang,M
AU - Ma,Y
AU - Korchev,Y
AU - Ivanov,A
AU - Edel,J
DO - 10.1021/acsami.8b13721
EP - 38629
PY - 2018///
SN - 1944-8244
SP - 38621
TI - Gated single-molecule transport in double-barreled nanopores
T2 - ACS Applied Materials and Interfaces
UR -
UR -
VL - 10
ER -