Imperial College London

Professor Joshua B. Edel

Faculty of Natural SciencesDepartment of Chemistry

Professor of Biosensing & Analytical Sciences



+44 (0)20 7594 0754joshua.edel Website




Mr John Murrell +44 (0)20 7594 2845




442AChemistrySouth Kensington Campus






BibTex format

author = {Cadinu, P and Paulose, Nadappuram B and Lee, DJ and Sze, JYY and Campolo, G and Zhang, Y and Shevchuk, A and Ladame, S and Albrecht, T and Korchev, Y and Ivanov, AP and Edel, JB},
doi = {10.1021/acs.nanolett.7b03196},
journal = {Nano letters},
pages = {6376--6384},
title = {Single Molecule Trapping and Sensing Using Dual Nanopores Separated by a Zeptoliter Nanobridge.},
url = {},
volume = {17},
year = {2017}

RIS format (EndNote, RefMan)

AB - There is a growing realization, especially within the diagnostic and therapeutic community, that the amount of information enclosed in a single molecule can not only enable a better understanding of biophysical pathways, but also offer exceptional value for early stage biomarker detection of disease onset. To this end, numerous single molecule strategies have been proposed, and in terms of label-free routes, nanopore sensing has emerged as one of the most promising methods. However, being able to finely control molecular transport in terms of transport rate, resolution, and signal-to-noise ratio (SNR) is essential to take full advantage of the technology benefits. Here we propose a novel solution to these challenges based on a method that allows biomolecules to be individually confined into a zeptoliter nanoscale droplet bridging two adjacent nanopores (nanobridge) with a 20 nm separation. Molecules that undergo confinement in the nanobridge are slowed down by up to 3 orders of magnitude compared to conventional nanopores. This leads to a dramatic improvement in the SNR, resolution, sensitivity, and limit of detection. The strategy implemented is universal and as highlighted in this manuscript can be used for the detection of dsDNA, RNA, ssDNA, and proteins.
AU - Cadinu,P
AU - Paulose,Nadappuram B
AU - Lee,DJ
AU - Sze,JYY
AU - Campolo,G
AU - Zhang,Y
AU - Shevchuk,A
AU - Ladame,S
AU - Albrecht,T
AU - Korchev,Y
AU - Ivanov,AP
AU - Edel,JB
DO - 10.1021/acs.nanolett.7b03196
EP - 6384
PY - 2017///
SN - 1530-6984
SP - 6376
TI - Single Molecule Trapping and Sensing Using Dual Nanopores Separated by a Zeptoliter Nanobridge.
T2 - Nano letters
UR -
UR -
VL - 17
ER -