Imperial College London

Professor Joshua B. Edel

Faculty of Natural SciencesDepartment of Chemistry

Professor of Biosensing & Analytical Sciences
 
 
 
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Contact

 

+44 (0)20 7594 0754joshua.edel Website

 
 
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Assistant

 

Mr John Murrell +44 (0)20 7594 2845

 
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Location

 

442AChemistrySouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Cadinu:2018:10.1021/acs.nanolett.8b00860,
author = {Cadinu, P and Campolo, G and Pud, S and Yang, W and Edel, J and Dekker, C and Ivanov, A},
doi = {10.1021/acs.nanolett.8b00860},
journal = {Nano Letters},
pages = {2738--2745},
title = {Double barrel nanopores as a new tool for controlling single-molecule transport},
url = {http://dx.doi.org/10.1021/acs.nanolett.8b00860},
volume = {18},
year = {2018}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - The ability to control the motion of single biomolecules is key to improving a wide range of biophysical and diagnostic applications. Solid-state nanopores are a promising tool capable of solving this task. However, molecular control and the possibility of slow readouts of long polymer molecules are still limited due to fast analyte transport and low signal-to-noise ratios. Here, we report on a novel approach of actively controlling analyte transport by using a double-nanopore architecture where two nanopores are separated by only a ∼ 20 nm gap. The nanopores can be addressed individually, allowing for two unique modes of operation: (i) pore-to-pore transfer, which can be controlled at near 100% efficiency, and (ii) DNA molecules bridging between the two nanopores, which enables detection with an enhanced temporal resolution (e.g., an increase of more than 2 orders of magnitude in the dwell time) without compromising the signal quality. The simplicity of fabrication and operation of the double-barrel architecture opens a wide range of applications for high-resolution readout of biological molecules.
AU - Cadinu,P
AU - Campolo,G
AU - Pud,S
AU - Yang,W
AU - Edel,J
AU - Dekker,C
AU - Ivanov,A
DO - 10.1021/acs.nanolett.8b00860
EP - 2745
PY - 2018///
SN - 1530-6984
SP - 2738
TI - Double barrel nanopores as a new tool for controlling single-molecule transport
T2 - Nano Letters
UR - http://dx.doi.org/10.1021/acs.nanolett.8b00860
UR - http://hdl.handle.net/10044/1/58482
VL - 18
ER -