Imperial College London

Professor Joshua B. Edel

Faculty of Natural SciencesDepartment of Chemistry

Professor of Biosensing & Analytical Sciences
 
 
 
//

Contact

 

+44 (0)20 7594 0754joshua.edel Website

 
 
//

Assistant

 

Mrs Althea Hartley-Forbes +44 (0)20 7594 5717

 
//

Location

 

442AChemistrySouth Kensington Campus

//

Summary

 

Publications

Publication Type
Year
to

138 results found

Cadinu P, Paulose Nadappuram B, Lee DJ, Sze JYY, Campolo G, Zhang Y, Shevchuk A, Ladame S, Albrecht T, Korchev Y, Ivanov AP, Edel JBet al., 2017, Single Molecule Trapping and Sensing Using Dual Nanopores Separated by a Zeptoliter Nanobridge., Nano Lett

There is a growing realization, especially within the diagnostic and therapeutic community, that the amount of information enclosed in a single molecule can not only enable a better understanding of biophysical pathways, but also offer exceptional value for early stage biomarker detection of disease onset. To this end, numerous single molecule strategies have been proposed, and in terms of label-free routes, nanopore sensing has emerged as one of the most promising methods. However, being able to finely control molecular transport in terms of transport rate, resolution, and signal-to-noise ratio (SNR) is essential to take full advantage of the technology benefits. Here we propose a novel solution to these challenges based on a method that allows biomolecules to be individually confined into a zeptoliter nanoscale droplet bridging two adjacent nanopores (nanobridge) with a 20 nm separation. Molecules that undergo confinement in the nanobridge are slowed down by up to 3 orders of magnitude compared to conventional nanopores. This leads to a dramatic improvement in the SNR, resolution, sensitivity, and limit of detection. The strategy implemented is universal and as highlighted in this manuscript can be used for the detection of dsDNA, RNA, ssDNA, and proteins.

JOURNAL ARTICLE

Gielen F, Butz M, Rees EJ, Erdelyi M, Moschetti T, Hyvonen M, Edel JB, Kaminski CF, Hollfelder Fet al., 2017, Quantitative Affinity Determination by Fluorescence Anisotropy Measurements of Individual Nanoliter Droplets, ANALYTICAL CHEMISTRY, Vol: 89, Pages: 1092-1101, ISSN: 0003-2700

JOURNAL ARTICLE

Lauri A, Velleman L, Xiao X, Cortes E, Edel JB, Giannini V, Rakovich A, Maier SAet al., 2017, 3D Confocal Raman Tomography to Probe Field Enhancements inside Supercluster Metamaterials, ACS PHOTONICS, Vol: 4, Pages: 2070-2077, ISSN: 2330-4022

JOURNAL ARTICLE

Lin X, Ivanov AP, Edel JB, 2017, Selective single molecule nanopore sensing of proteins using DNA aptamer-functionalised gold nanoparticles, CHEMICAL SCIENCE, Vol: 8, Pages: 3905-3912, ISSN: 2041-6520

JOURNAL ARTICLE

Montelongo Y, Sikdar D, Ma Y, McIntosh AJS, Velleman L, Kucernak AR, Edel JB, Kornyshev AAet al., 2017, Electrotunable nanoplasmonic liquid mirror., Nat Mater, ISSN: 1476-1122

Recently, there has been a drive to design and develop fully tunable metamaterials for applications ranging from new classes of sensors to superlenses among others. Although advances have been made, tuning and modulating the optical properties in real time remains a challenge. We report on the first realization of a reversible electrotunable liquid mirror based on voltage-controlled self-assembly/disassembly of 16 nm plasmonic nanoparticles at the interface between two immiscible electrolyte solutions. We show that optical properties such as reflectivity and spectral position of the absorption band can be varied in situ within ±0.5 V. This observed effect is in excellent agreement with theoretical calculations corresponding to the change in average interparticle spacing. This electrochemical fully tunable nanoplasmonic platform can be switched from a highly reflective 'mirror' to a transmissive 'window' and back again. This study opens a route towards realization of such platforms in future micro/nanoscale electrochemical cells, enabling the creation of tunable plasmonic metamaterials.

JOURNAL ARTICLE

Velleman L, Scarabelli L, Sikdar D, Kornyshev AA, Liz-Marzan LM, Edel Jet al., 2017, Monitoring plasmon coupling and SERS enhancement through in situ nanoparticle spacing modulation, Faraday Discuss., ISSN: 1359-6640

JOURNAL ARTICLE

Bougot-Robin K, Hoste JW, Le Thomas N, Bienstman P, Edel JBet al., 2016, Highly sensitive detection using microring resonator and nanopores, Conference on Optical Sensing and Detection IV, Publisher: SPIE-INT SOC OPTICAL ENGINEERING, ISSN: 0277-786X

CONFERENCE PAPER

Bougot-Robin K, Paget J, Atkins SC, Edel JBet al., 2016, Optimization and Design of an Absorbance Spectrometer Controlled Using a Raspberry Pi To Improve Analytical Skills, JOURNAL OF CHEMICAL EDUCATION, Vol: 93, Pages: 1232-1240, ISSN: 0021-9584

JOURNAL ARTICLE

Crick CR, Noimark S, Peveler WJ, Bear JC, Ivanov AP, Edel JB, Parkin IPet al., 2016, Advanced Compositional Analysis of Nanoparticle-polymer Composites Using Direct Fluorescence Imaging, JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, ISSN: 1940-087X

JOURNAL ARTICLE

Edel JB, Kornyshev AA, Kucernak AR, Urbakh Met al., 2016, Fundamentals and applications of self-assembled plasmonic nanoparticles at interfaces, CHEMICAL SOCIETY REVIEWS, Vol: 45, Pages: 1581-1596, ISSN: 0306-0012

JOURNAL ARTICLE

Elani Y, Solvas XCI, Edel JB, Law RV, Ces Oet al., 2016, Microfluidic generation of encapsulated droplet interface bilayer networks (multisomes) and their use as cell-like reactors, CHEMICAL COMMUNICATIONS, Vol: 52, Pages: 5961-5964, ISSN: 1359-7345

JOURNAL ARTICLE

Freedman KJ, Crick CR, Albella P, Barik A, Ivanov AP, Maier SA, Oh S-H, Edel JBet al., 2016, On-Demand Surface- and Tip-Enhanced Raman Spectroscopy Using Dielectrophoretic Trapping and Nanopore Sensing, ACS PHOTONICS, Vol: 3, Pages: 1036-1044, ISSN: 2330-4022

JOURNAL ARTICLE

Freedman KJ, Otto LM, Ivanov AP, Barik A, Oh S-H, Edel JBet al., 2016, Nanopore sensing at ultra-low concentrations using single-molecule dielectrophoretic trapping, NATURE COMMUNICATIONS, Vol: 7, ISSN: 2041-1723

JOURNAL ARTICLE

Kumar S, Johnson TW, Wood CK, Qu T, Wittenberg NJ, Otto LM, Shaver J, Long NJ, Victora RH, Edel JB, Oh S-Het al., 2016, Template-Stripped Multifunctional Wedge and Pyramid Arrays for Magnetic Nanofocusing and Optical Sensing, ACS APPLIED MATERIALS & INTERFACES, Vol: 8, Pages: 9319-9326, ISSN: 1944-8244

JOURNAL ARTICLE

Panich S, Sleiman MH, Steer I, Ladame S, Edel JBet al., 2016, Real-Time Monitoring of Ligand Binding to G-Quadruplex and Duplex DNA by Whispering Gallery Mode Sensing, ACS SENSORS, Vol: 1, Pages: 1097-1102, ISSN: 2379-3694

JOURNAL ARTICLE

Sikdar D, Hasan SB, Urbakh M, Edel JB, Kornyshev AAet al., 2016, Unravelling the optical responses of nanoplasmonic mirror-on-mirror metamaterials, PHYSICAL CHEMISTRY CHEMICAL PHYSICS, Vol: 18, Pages: 20486-20498, ISSN: 1463-9076

JOURNAL ARTICLE

Turek VA, Francescato Y, Cadinu P, Crick CR, Elliott L, Chen Y, Urland V, Ivanov AP, Velleman L, Hong M, Vilar R, Maier SA, Giannini V, Edel JBet al., 2016, Self-Assembled Spherical Supercluster Metamaterials from Nanoscale Building Blocks, ACS PHOTONICS, Vol: 3, Pages: 35-42, ISSN: 2330-4022

JOURNAL ARTICLE

Velleman L, Sikdar D, Turek VA, Kucernak AR, Roser SJ, Kornyshev AA, Edel JBet al., 2016, Tuneable 2D self-assembly of plasmonic nanoparticles at liquid| liquid interfaces, NANOSCALE, Vol: 8, Pages: 19229-19241, ISSN: 2040-3364

JOURNAL ARTICLE

Crick CR, Noimark S, Peveler WJ, Bear JC, Ivanov AP, Edel JB, Parkin IPet al., 2015, Advanced analysis of nanoparticle composites - a means toward increasing the efficiency of functional materials, RSC ADVANCES, Vol: 5, Pages: 53789-53795, ISSN: 2046-2069

JOURNAL ARTICLE

Crick CR, Sze JYY, Rosillo-Lopez M, Salzmann CG, Edel JBet al., 2015, Selectively Sized Graphene-Based Nanopores for in Situ Single Molecule Sensing, ACS APPLIED MATERIALS & INTERFACES, Vol: 7, Pages: 18188-18194, ISSN: 1944-8244

JOURNAL ARTICLE

Edel J, Oh S-H, 2015, Editorial - From nanopores to nanochannels, ANALYST, Vol: 140, Pages: 4732-4732, ISSN: 0003-2654

JOURNAL ARTICLE

Ivanov AP, Actis P, J├Ânsson P, Klenerman DK, Korchev Y, Edel JBet al., 2015, On-Demand Delivery of Single DNA Molecules Using Nanopipettes, ACS Nano, Vol: 9, Pages: 3587-3595, ISSN: 1936-086X

JOURNAL ARTICLE

Kang D-K, Gong X, Cho S, Kim J-Y, Edel JB, Chang S-I, Choo J, deMello AJet al., 2015, 3D Droplet Microfluidic Systems for High-Throughput Biological Experimentation, ANALYTICAL CHEMISTRY, Vol: 87, Pages: 10770-10778, ISSN: 0003-2700

JOURNAL ARTICLE

Kang DK, Gong X, Cho S, Kim JY, Edel J, Chang SI, Choo J, De Mello AJet al., 2015, 3D droplet microfluidic system for high-throughput biological assay, Pages: 897-899

© 15CBMS-0001. Herein, we describe the development of a multilayer droplet microfluidic system for creating concentration gradients and generating microdroplets of varying composition for high-throughput biochemical and cell-based screening applications. The 3D droplet-based microfluidic device consists of multiple PDMS layers, which are used to generate logarithmic concentration gradient reagent profiles. Parallel flow focusing structures are used to form picoliter-sized droplets of defined volumes but of varying composition. As proof of concept, we demonstrate rapid enzymatic activity assays and drug cytotoxicity assays on bacteria. The 3D droplet-based microfluidic platform has the potential to allow for high-efficiency and high-throughput analysis, overcoming the structural limitations of single layer microfluidic systems.

CONFERENCE PAPER

Kucernak ARJ, edel, turek, cecchini, pagetet al., 2015, Document METHOD OF DETECTING AN ANALYTE IN A SAMPLE USING RAMAN SPECTROSCOPY, INFRA RED SPECTROSCOPY AND/OR FLUORESCENCE SPECTROSCOPY | [VERFAHREN ZUM NACHWEIS EINES ANALYTEN IN EINER PROBE MITTELS RAMAN-SPEKTROSKOPIE, INFRAROTSPEKTROSKOPIE UND/ODER FLUORESZENZSPEKTROSKOPIE], EP2880425

PATENT

Pitchford WH, Kim H-J, Ivanov AP, Kim H-M, Yu J-S, Leatherbarrow RJ, Albrecht T, Kim K-B, Edel JBet al., 2015, Synchronized Optical and Electronic Detection of Biomolecules Using a Low Noise Nanopore Platform, ACS NANO, Vol: 9, Pages: 1740-1748, ISSN: 1936-0851

JOURNAL ARTICLE

Rutkowska A, Freedman K, Skalkowska J, Kim MJ, Edel JB, Albrecht Tet al., 2015, Electrodeposition and Bipolar Effects in Metallized Nanopores and Their Use in the Detection of Insulin, ANALYTICAL CHEMISTRY, Vol: 87, Pages: 2337-2344, ISSN: 0003-2700

JOURNAL ARTICLE

Sze JYY, Kumar S, Ivanov AP, Oh S-H, Edel JBet al., 2015, Fine tuning of nanopipettes using atomic layer deposition for single molecule sensing, ANALYST, Vol: 140, Pages: 4828-4834, ISSN: 0003-2654

JOURNAL ARTICLE

edel, turek, cecchini, Kornyshev, Paget, kucernaket al., 2015, METHOD OF DETECTING AN ANALYTE IN A SAMPLE USING RAMAN SPECTROSCOPY, INFRA RED SPECTROSCOPY AND/OR FLUORESCENCE SPECTROSCOPY

The invention relates to a method of detecting the presence of an analyte associated with a nanoparticle layer formed at a liquid-liquid interface. The method comprises removing a portion of one of the liquid phases; and detecting the presence of the analyte by Raman spectroscopy, Infra Red spectroscopy and/or fluorescence spectroscopy. The invention further relates to a kit for use in the method, comprising a sample vessel for receiving in use, a first and second liquid phase; wherein said phases are immiscible and wherein one or both of the first or the second liquid phase comprise nanoparticles, and instructions to allow analysis of an analyte in a sample according to the claimed method

PATENT

Cecchini MP, Turek VA, Demetriadou A, Britovsek G, Welton T, Kornyshev AA, Wilton-Ely JDET, Edel JBet al., 2014, Heavy Metal Sensing Using Self-Assembled Nanoparticles at a Liquid-Liquid Interface, ADVANCED OPTICAL MATERIALS, Vol: 2, Pages: 966-977, ISSN: 2195-1071

JOURNAL ARTICLE

This data is extracted from the Web of Science and reproduced under a licence from Thomson Reuters. You may not copy or re-distribute this data in whole or in part without the written consent of the Science business of Thomson Reuters.

Request URL: http://wlsprd.imperial.ac.uk:80/respub/WEB-INF/jsp/search-html.jsp Request URI: /respub/WEB-INF/jsp/search-html.jsp Query String: respub-action=search.html&id=00474271&limit=30&person=true