153 results found
Montelongo Y, Sikdar D, Ma Y, et al., 2019, Author Correction: Electrotunable nanoplasmonic liquid mirror., Nat Mater, ISSN: 1476-1122
In the version of this Article originally published, the last sentence of the acknowledgements incorrectly read 'L.V. acknowledges the support of a Marie Skodowska-Curie fellowship (N-SHEAD)'; it should have read 'L.V. and D.S. acknowledge the support of Marie Skłodowska-Curie fellowships, N-SHEAD and S-OMMs, respectively'.
Kubánková M, Lin X, Albrecht T, et al., 2019, Rapid Fragmentation during Seeded Lysozyme Aggregation Revealed at the Single Molecule Level., Anal Chem
Protein aggregation is associated with neurodegenerative disorders such as Alzheimer's and Parkinson's diseases. The poorly understood pathogenic mechanism of amyloid diseases makes early stage diagnostics or therapeutic intervention a challenge. Seeded polymerization that reduces the duration of the lag phase and accelerates fibril growth is a widespread model to study amyloid formation. Seeding effects are hypothesized to be important in the "infectivity" of amyloids and are linked to the development of systemic amyloidosis in vivo. The exact mechanism of seeding is unclear yet critical to illuminating the propagation of amyloids. Here we report on the lateral and axial fragmentation of seed fibrils in the presence of lysozyme monomers at short time scales, followed by the generation of oligomers and growth of fibrils.
Cai S, Sze JYY, Ivanov AP, et al., 2019, Small molecule electro-optical binding assay using nanopores, NATURE COMMUNICATIONS, Vol: 10, ISSN: 2041-1723
Xue L, Cadinu P, Nadappuram BP, et al., 2018, Gated Single-Molecule Transport in Double-Barreled Nanopores, ACS APPLIED MATERIALS & INTERFACES, Vol: 10, Pages: 38621-38629, ISSN: 1944-8244
Ma Y, Zagar C, Klemme DJ, et al., 2018, A Tunable Nanoplasmonic Mirror at an Electrochemical Interface, ACS PHOTONICS, Vol: 5, Pages: 4604-4616, ISSN: 2330-4022
Al Sulaiman D, Cadinu P, Ivanov AP, et al., 2018, Chemically Modified Hydrogel-Filled Nanopores: A Tunable Platform for Single-Molecule Sensing, NANO LETTERS, Vol: 18, Pages: 6084-6093, ISSN: 1530-6984
Ivanov AP, Edel JB, 2018, Scissoring genes with light, NATURE CHEMISTRY, Vol: 10, Pages: 800-801, ISSN: 1755-4330
Rakers V, Cadinu P, Edel JB, et al., 2018, Development of microfluidic platforms for the synthesis of metal complexes and evaluation of their DNA affinity using online FRET melting assays, CHEMICAL SCIENCE, Vol: 9, Pages: 3459-3469, ISSN: 2041-6520
Cadinu P, Campolo G, Pud S, et al., 2018, Double Barrel Nanopores as a New Tool for Controlling Single-Molecule Transport, NANO LETTERS, Vol: 18, Pages: 2738-2745, ISSN: 1530-6984
HayleyWeir, Edel JB, Kornyshev AA, et al., 2018, Towards Electrotuneable Nanoplasmonic Fabry-Perot Interferometer, SCIENTIFIC REPORTS, Vol: 8, ISSN: 2045-2322
Peveler WJ, Noimark S, Al-Azawi H, et al., 2018, Covalently Attached Antimicrobial Surfaces Using BODIPY: Improving Efficiency and Effectiveness, ACS APPLIED MATERIALS & INTERFACES, Vol: 10, Pages: 98-104, ISSN: 1944-8244
Aizpurua J, Arnolds H, Baumberg J, et al., 2017, Ultrasensitive and towards single molecule SERS: general discussion, FARADAY DISCUSSIONS, Vol: 205, Pages: 291-330, ISSN: 1359-6640
Velleman L, Scarabelli L, Sikdar D, et al., 2017, Monitoring plasmon coupling and SERS enhancement through in situ nanoparticle spacing modulation, FARADAY DISCUSSIONS, Vol: 205, Pages: 67-83, ISSN: 1359-6640
Barik A, Zhang Y, Grassi R, et al., 2017, Graphene-edge dielectrophoretic tweezers for trapping of biomolecules, NATURE COMMUNICATIONS, Vol: 8, ISSN: 2041-1723
Sze JYY, Ivanov AP, Cass AEG, et al., 2017, Single molecule multiplexed nanopore protein screening in human serum using aptamer modified DNA carriers, NATURE COMMUNICATIONS, Vol: 8, ISSN: 2041-1723
Crick CR, Albella P, Kim H-J, et al., 2017, Low-Noise Plasmonic Nanopore Biosensors for Single Molecule Detection at Elevated Temperatures, ACS PHOTONICS, Vol: 4, Pages: 2835-2842, ISSN: 2330-4022
Recently, there has been a drive to design and develop fully tunable metamaterials for applications ranging from new classes of sensors to superlenses among others. Although advances have been made, tuning and modulating the optical properties in real time remains a challenge. We report on the first realization of a reversible electrotunable liquid mirror based on voltage-controlled self-assembly/disassembly of 16 nm plasmonic nanoparticles at the interface between two immiscible electrolyte solutions. We show that optical properties such as reflectivity and spectral position of the absorption band can be varied in situ within ±0.5 V. This observed effect is in excellent agreement with theoretical calculations corresponding to the change in average interparticle spacing. This electrochemical fully tunable nanoplasmonic platform can be switched from a highly reflective 'mirror' to a transmissive 'window' and back again. This study opens a route towards realization of such platforms in future micro/nanoscale electrochemical cells, enabling the creation of tunable plasmonic metamaterials.
Cadinu P, Paulose Nadappuram B, Lee DJ, et al., 2017, Single Molecule Trapping and Sensing Using Dual Nanopores Separated by a Zeptoliter Nanobridge., Nano letters, Vol: 17, Pages: 6376-6384, ISSN: 1530-6984
There is a growing realization, especially within the diagnostic and therapeutic community, that the amount of information enclosed in a single molecule can not only enable a better understanding of biophysical pathways, but also offer exceptional value for early stage biomarker detection of disease onset. To this end, numerous single molecule strategies have been proposed, and in terms of label-free routes, nanopore sensing has emerged as one of the most promising methods. However, being able to finely control molecular transport in terms of transport rate, resolution, and signal-to-noise ratio (SNR) is essential to take full advantage of the technology benefits. Here we propose a novel solution to these challenges based on a method that allows biomolecules to be individually confined into a zeptoliter nanoscale droplet bridging two adjacent nanopores (nanobridge) with a 20 nm separation. Molecules that undergo confinement in the nanobridge are slowed down by up to 3 orders of magnitude compared to conventional nanopores. This leads to a dramatic improvement in the SNR, resolution, sensitivity, and limit of detection. The strategy implemented is universal and as highlighted in this manuscript can be used for the detection of dsDNA, RNA, ssDNA, and proteins.
Ren R, Zhang Y, Nadappuram BP, et al., 2017, Nanopore extended field-effect transistor for selective single-molecule biosensing, NATURE COMMUNICATIONS, Vol: 8, ISSN: 2041-1723
Lauri A, Velleman L, Xiao X, et al., 2017, 3D Confocal Raman Tomography to Probe Field Enhancements inside Supercluster Metamaterials, ACS PHOTONICS, Vol: 4, Pages: 2070-2077, ISSN: 2330-4022
Lin X, Ivanov AP, Edel JB, 2017, Selective single molecule nanopore sensing of proteins using DNA aptamer-functionalised gold nanoparticles, CHEMICAL SCIENCE, Vol: 8, Pages: 3905-3912, ISSN: 2041-6520
Gielen F, Butz M, Rees EJ, et al., 2017, Quantitative Affinity Determination by Fluorescence Anisotropy Measurements of Individual Nanoliter Droplets, ANALYTICAL CHEMISTRY, Vol: 89, Pages: 1092-1101, ISSN: 0003-2700
Panich S, Sleiman MH, Steer I, et al., 2016, Real-Time Monitoring of Ligand Binding to G-Quadruplex and Duplex DNA by Whispering Gallery Mode Sensing, ACS SENSORS, Vol: 1, Pages: 1097-1102, ISSN: 2379-3694
Sikdar D, Hasan SB, Urbakh M, et al., 2016, Unravelling the optical responses of nanoplasmonic mirror-on-mirror metamaterials, PHYSICAL CHEMISTRY CHEMICAL PHYSICS, Vol: 18, Pages: 20486-20498, ISSN: 1463-9076
Bougot-Robin K, Paget J, Atkins SC, et al., 2016, Optimization and Design of an Absorbance Spectrometer Controlled Using a Raspberry Pi To Improve Analytical Skills, JOURNAL OF CHEMICAL EDUCATION, Vol: 93, Pages: 1232-1240, ISSN: 0021-9584
Crick CR, Noimark S, Peveler WJ, et al., 2016, Advanced Compositional Analysis of Nanoparticle-polymer Composites Using Direct Fluorescence Imaging, JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, ISSN: 1940-087X
Freedman KJ, Crick CR, Albella P, et al., 2016, On-Demand Surface- and Tip-Enhanced Raman Spectroscopy Using Dielectrophoretic Trapping and Nanopore Sensing, ACS PHOTONICS, Vol: 3, Pages: 1036-1044, ISSN: 2330-4022
Kumar S, Johnson TW, Wood CK, et al., 2016, Template-Stripped Multifunctional Wedge and Pyramid Arrays for Magnetic Nanofocusing and Optical Sensing, ACS APPLIED MATERIALS & INTERFACES, Vol: 8, Pages: 9319-9326, ISSN: 1944-8244
Velleman L, Sikdar D, Turek VA, et al., 2016, Tuneable 2D self-assembly of plasmonic nanoparticles at liquid| liquid interfaces, NANOSCALE, Vol: 8, Pages: 19229-19241, ISSN: 2040-3364
This data is extracted from the Web of Science and reproduced under a licence from Thomson Reuters. You may not copy or re-distribute this data in whole or in part without the written consent of the Science business of Thomson Reuters.