Imperial College London

Professor Joshua B. Edel

Faculty of Natural SciencesDepartment of Chemistry

Professor of Biosensing & Analytical Sciences
 
 
 
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Contact

 

+44 (0)20 7594 0754joshua.edel Website

 
 
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Assistant

 

Mrs Althea Hartley-Forbes +44 (0)20 7594 5717

 
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Location

 

442AChemistrySouth Kensington Campus

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Summary

 

Publications

Publication Type
Year
to

147 results found

Al Sulaiman D, Cadinu P, Ivanov AP, Edel JB, Ladame Set al., 2018, Chemically Modified Hydrogel-Filled Nanopores: A Tunable Platform for Single-Molecule Sensing., Nano Lett

Label-free, single-molecule sensing is anideal candidate for biomedical applications that rely on the detection of low copy numbers in small volumes and potentially complex biofluids. Among them, solid-state nanopores can be engineered to detect single molecules of charged analytes when they are electrically driven through the nanometer-sized aperture. When successfully applied to nucleic acid sensing, fast transport in the range of 10-100 nucleotides per nanosecond often precludes the use of standard nanopores for the detection of the smallest fragments. Herein, hydrogel-filled nanopores (HFN) are reported that combine quartz nanopipettes with biocompatible chemical poly(vinyl) alcohol hydrogels engineered in-house. Hydrogels were modified physically or chemically to finely tune, in a predictable manner, the transport of specific molecules. Controlling the hydrogel mesh size and chemical composition allowed us to slow DNA transport by 4 orders of magnitude and to detect fragments as small as 100 base pairs (bp) with nanopores larger than 20 nm at an ionic strength comparable to physiological conditions. Considering the emergence of cell-free nucleic acids as blood biomarkers for cancer diagnostics or prenatal testing, the successful sensing and size profiling of DNA fragments ranging from 100 bp to >1 kbp long under physiological conditions demonstrates the potential of HFNs as a new generation of powerful and easily tunable molecular diagnostics tools.

JOURNAL ARTICLE

Cadinu P, Campolo G, Pud S, Yang W, Edel JB, Dekker C, Ivanov APet al., 2018, Double Barrel Nanopores as a New Tool for Controlling Single-Molecule Transport, NANO LETTERS, Vol: 18, Pages: 2738-2745, ISSN: 1530-6984

JOURNAL ARTICLE

HayleyWeir, Edel JB, Kornyshev AA, Sikdar Det al., 2018, Towards Electrotuneable Nanoplasmonic Fabry-Perot Interferometer, SCIENTIFIC REPORTS, Vol: 8, ISSN: 2045-2322

JOURNAL ARTICLE

Ivanov AP, Edel JB, 2018, Scissoring genes with light, NATURE CHEMISTRY, Vol: 10, Pages: 800-801, ISSN: 1755-4330

JOURNAL ARTICLE

Peveler WJ, Noimark S, Al-Azawi H, Hwang GB, Crick CR, Allan E, Edel JB, Ivanov AP, MacRobert AJ, Parkin IPet al., 2018, Covalently Attached Antimicrobial Surfaces Using BODIPY: Improving Efficiency and Effectiveness, ACS APPLIED MATERIALS & INTERFACES, Vol: 10, Pages: 98-104, ISSN: 1944-8244

JOURNAL ARTICLE

Rakers V, Cadinu P, Edel JB, Vilar Ret al., 2018, Development of microfluidic platforms for the synthesis of metal complexes and evaluation of their DNA affinity using online FRET melting assays, CHEMICAL SCIENCE, Vol: 9, Pages: 3459-3469, ISSN: 2041-6520

JOURNAL ARTICLE

Aizpurua J, Arnolds H, Baumberg J, Bruzas I, Chikkaraddy R, Chisanga M, Dawson P, Deckert V, Delfino I, de Nijs B, Di Martino G, Edel J, Fleming H, Gawinkowski S, Giorgis F, Goodacre R, Graham D, Hardy M, Heck C, Heeg S, Hewitt K, Jamieson L, Keeler A, Krolikowska A, Kuttner C, Lidgi-Guigui N, Lightner C, Lombardi J, Mahajan S, Sabanes NM, Masson J-F, Mueller NS, Muhamadali H, Murakoshi K, Popp J, Porter M, Reich S, Schatz G, Tian Z-Q, Tripathi A, Van Duyne R, Wang X, Wark A, Willets KK, Willner Met al., 2017, Ultrasensitive and towards single molecule SERS: general discussion, FARADAY DISCUSSIONS, Vol: 205, Pages: 291-330, ISSN: 1359-6640

JOURNAL ARTICLE

Barik A, Zhang Y, Grassi R, Nadappuram BP, Edel JB, Low T, Koester SJ, Oh S-Het al., 2017, Graphene-edge dielectrophoretic tweezers for trapping of biomolecules, NATURE COMMUNICATIONS, Vol: 8, ISSN: 2041-1723

JOURNAL ARTICLE

Cadinu P, Paulose Nadappuram B, Lee DJ, Sze JYY, Campolo G, Zhang Y, Shevchuk A, Ladame S, Albrecht T, Korchev Y, Ivanov AP, Edel JBet al., 2017, Single Molecule Trapping and Sensing Using Dual Nanopores Separated by a Zeptoliter Nanobridge., Nano letters, Vol: 17, Pages: 6376-6384, ISSN: 1530-6984

There is a growing realization, especially within the diagnostic and therapeutic community, that the amount of information enclosed in a single molecule can not only enable a better understanding of biophysical pathways, but also offer exceptional value for early stage biomarker detection of disease onset. To this end, numerous single molecule strategies have been proposed, and in terms of label-free routes, nanopore sensing has emerged as one of the most promising methods. However, being able to finely control molecular transport in terms of transport rate, resolution, and signal-to-noise ratio (SNR) is essential to take full advantage of the technology benefits. Here we propose a novel solution to these challenges based on a method that allows biomolecules to be individually confined into a zeptoliter nanoscale droplet bridging two adjacent nanopores (nanobridge) with a 20 nm separation. Molecules that undergo confinement in the nanobridge are slowed down by up to 3 orders of magnitude compared to conventional nanopores. This leads to a dramatic improvement in the SNR, resolution, sensitivity, and limit of detection. The strategy implemented is universal and as highlighted in this manuscript can be used for the detection of dsDNA, RNA, ssDNA, and proteins.

JOURNAL ARTICLE

Crick CR, Albella P, Kim H-J, Ivanov AP, Kim K-B, Maier SA, Edel JBet al., 2017, Low-Noise Plasmonic Nanopore Biosensors for Single Molecule Detection at Elevated Temperatures, ACS PHOTONICS, Vol: 4, Pages: 2835-2842, ISSN: 2330-4022

JOURNAL ARTICLE

Gielen F, Butz M, Rees EJ, Erdelyi M, Moschetti T, Hyvonen M, Edel JB, Kaminski CF, Hollfelder Fet al., 2017, Quantitative Affinity Determination by Fluorescence Anisotropy Measurements of Individual Nanoliter Droplets, ANALYTICAL CHEMISTRY, Vol: 89, Pages: 1092-1101, ISSN: 0003-2700

JOURNAL ARTICLE

Lauri A, Velleman L, Xiao X, Cortes E, Edel JB, Giannini V, Rakovich A, Maier SAet al., 2017, 3D Confocal Raman Tomography to Probe Field Enhancements inside Supercluster Metamaterials, ACS PHOTONICS, Vol: 4, Pages: 2070-2077, ISSN: 2330-4022

JOURNAL ARTICLE

Lin X, Ivanov AP, Edel JB, 2017, Selective single molecule nanopore sensing of proteins using DNA aptamer-functionalised gold nanoparticles, CHEMICAL SCIENCE, Vol: 8, Pages: 3905-3912, ISSN: 2041-6520

JOURNAL ARTICLE

Montelongo Y, Sikdar D, Ma Y, McIntosh AJS, Velleman L, Kucernak AR, Edel JB, Kornyshev AAet al., 2017, Electrotunable nanoplasmonic liquid mirror., Nature materials, Vol: 16, Pages: 1127-1135, ISSN: 1476-1122

Recently, there has been a drive to design and develop fully tunable metamaterials for applications ranging from new classes of sensors to superlenses among others. Although advances have been made, tuning and modulating the optical properties in real time remains a challenge. We report on the first realization of a reversible electrotunable liquid mirror based on voltage-controlled self-assembly/disassembly of 16 nm plasmonic nanoparticles at the interface between two immiscible electrolyte solutions. We show that optical properties such as reflectivity and spectral position of the absorption band can be varied in situ within ±0.5 V. This observed effect is in excellent agreement with theoretical calculations corresponding to the change in average interparticle spacing. This electrochemical fully tunable nanoplasmonic platform can be switched from a highly reflective 'mirror' to a transmissive 'window' and back again. This study opens a route towards realization of such platforms in future micro/nanoscale electrochemical cells, enabling the creation of tunable plasmonic metamaterials.

JOURNAL ARTICLE

Ren R, Zhang Y, Nadappuram BP, Akpinar B, Klenerman D, Ivanov AP, Edel JB, Korchev Yet al., 2017, Nanopore extended field-effect transistor for selective single-molecule biosensing, NATURE COMMUNICATIONS, Vol: 8, ISSN: 2041-1723

JOURNAL ARTICLE

Sze JYY, Ivanov AP, Cass AEG, Edel JBet al., 2017, Single molecule multiplexed nanopore protein screening in human serum using aptamer modified DNA carriers, NATURE COMMUNICATIONS, Vol: 8, ISSN: 2041-1723

JOURNAL ARTICLE

Velleman L, Scarabelli L, Sikdar D, Kornyshev AA, Liz-Marzan LM, Edel JBet al., 2017, Monitoring plasmon coupling and SERS enhancement through in situ nanoparticle spacing modulation, FARADAY DISCUSSIONS, Vol: 205, Pages: 67-83, ISSN: 1359-6640

JOURNAL ARTICLE

Bougot-Robin K, Hoste JW, Le Thomas N, Bienstman P, Edel JBet al., 2016, Highly sensitive detection using microring resonator and nanopores, Conference on Optical Sensing and Detection IV, Publisher: SPIE-INT SOC OPTICAL ENGINEERING, ISSN: 0277-786X

CONFERENCE PAPER

Bougot-Robin K, Paget J, Atkins SC, Edel JBet al., 2016, Optimization and Design of an Absorbance Spectrometer Controlled Using a Raspberry Pi To Improve Analytical Skills, JOURNAL OF CHEMICAL EDUCATION, Vol: 93, Pages: 1232-1240, ISSN: 0021-9584

JOURNAL ARTICLE

Crick CR, Noimark S, Peveler WJ, Bear JC, Ivanov AP, Edel JB, Parkin IPet al., 2016, Advanced Compositional Analysis of Nanoparticle-polymer Composites Using Direct Fluorescence Imaging, JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, ISSN: 1940-087X

JOURNAL ARTICLE

Edel JB, Kornyshev AA, Kucernak AR, Urbakh Met al., 2016, Fundamentals and applications of self-assembled plasmonic nanoparticles at interfaces, CHEMICAL SOCIETY REVIEWS, Vol: 45, Pages: 1581-1596, ISSN: 0306-0012

JOURNAL ARTICLE

Elani Y, Solvas XCI, Edel JB, Law RV, Ces Oet al., 2016, Microfluidic generation of encapsulated droplet interface bilayer networks (multisomes) and their use as cell-like reactors, CHEMICAL COMMUNICATIONS, Vol: 52, Pages: 5961-5964, ISSN: 1359-7345

JOURNAL ARTICLE

Freedman KJ, Crick CR, Albella P, Barik A, Ivanov AP, Maier SA, Oh S-H, Edel JBet al., 2016, On-Demand Surface- and Tip-Enhanced Raman Spectroscopy Using Dielectrophoretic Trapping and Nanopore Sensing, ACS PHOTONICS, Vol: 3, Pages: 1036-1044, ISSN: 2330-4022

JOURNAL ARTICLE

Freedman KJ, Otto LM, Ivanov AP, Barik A, Oh S-H, Edel JBet al., 2016, Nanopore sensing at ultra-low concentrations using single-molecule dielectrophoretic trapping, NATURE COMMUNICATIONS, Vol: 7, ISSN: 2041-1723

JOURNAL ARTICLE

Kumar S, Johnson TW, Wood CK, Qu T, Wittenberg NJ, Otto LM, Shaver J, Long NJ, Victora RH, Edel JB, Oh S-Het al., 2016, Template-Stripped Multifunctional Wedge and Pyramid Arrays for Magnetic Nanofocusing and Optical Sensing, ACS APPLIED MATERIALS & INTERFACES, Vol: 8, Pages: 9319-9326, ISSN: 1944-8244

JOURNAL ARTICLE

Panich S, Sleiman MH, Steer I, Ladame S, Edel JBet al., 2016, Real-Time Monitoring of Ligand Binding to G-Quadruplex and Duplex DNA by Whispering Gallery Mode Sensing, ACS SENSORS, Vol: 1, Pages: 1097-1102, ISSN: 2379-3694

JOURNAL ARTICLE

Sikdar D, Hasan SB, Urbakh M, Edel JB, Kornyshev AAet al., 2016, Unravelling the optical responses of nanoplasmonic mirror-on-mirror metamaterials, PHYSICAL CHEMISTRY CHEMICAL PHYSICS, Vol: 18, Pages: 20486-20498, ISSN: 1463-9076

JOURNAL ARTICLE

Turek VA, Francescato Y, Cadinu P, Crick CR, Elliott L, Chen Y, Urland V, Ivanov AP, Velleman L, Hong M, Vilar R, Maier SA, Giannini V, Edel JBet al., 2016, Self-Assembled Spherical Supercluster Metamaterials from Nanoscale Building Blocks, ACS PHOTONICS, Vol: 3, Pages: 35-42, ISSN: 2330-4022

JOURNAL ARTICLE

Velleman L, Sikdar D, Turek VA, Kucernak AR, Roser SJ, Kornyshev AA, Edel JBet al., 2016, Tuneable 2D self-assembly of plasmonic nanoparticles at liquid| liquid interfaces, NANOSCALE, Vol: 8, Pages: 19229-19241, ISSN: 2040-3364

JOURNAL ARTICLE

Crick CR, Noimark S, Peveler WJ, Bear JC, Ivanov AP, Edel JB, Parkin IPet al., 2015, Advanced analysis of nanoparticle composites - a means toward increasing the efficiency of functional materials, RSC ADVANCES, Vol: 5, Pages: 53789-53795, ISSN: 2046-2069

JOURNAL ARTICLE

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