Imperial College London

Professor Joshua B. Edel

Faculty of Natural SciencesDepartment of Chemistry

Professor of Biosensing & Analytical Sciences
 
 
 
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Contact

 

+44 (0)20 7594 0754joshua.edel Website

 
 
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Assistant

 

Mr John Murrell +44 (0)20 7594 2845

 
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Location

 

110cMolecular Sciences Research HubWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Cadinu:2020:10.1021/acs.nanolett.9b05307,
author = {Cadinu, P and Kang, M and Paulose, Nadappuram B and Ivanov, A and Edel, JB},
doi = {10.1021/acs.nanolett.9b05307},
journal = {Nano Letters},
pages = {2012--2019},
title = {Individually addressable multi-nanopores for single-molecule targeted operations},
url = {http://dx.doi.org/10.1021/acs.nanolett.9b05307},
volume = {20},
year = {2020}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - The fine-tuning of molecular transport is a ubiquitous problem of single-molecule methods. The latter is evident even in powerful single-molecule methods such as nanopore sensing, where the quest for resolving more detailed biomolecular features is often limited by insufficient control of the dynamics of individual molecules within the detection volume of the nanopore. In this work, we introduce and characterize a reconfigurable multi-nanopore architecture that enables additional channels to manipulate the dynamics of DNA molecules in a nanopore. We show that the fabrication process of this device, consisting of four adjacent, individually addressable nanopores located at the tip of a quartz nanopipette, is fast and highly reproducible. By individually tuning the electric field across each nanopore, these devices can operate in several unique cooperative detection modes that allow moving, sensing, and trapping DNA molecules with high efficiency and increased temporal resolution.
AU - Cadinu,P
AU - Kang,M
AU - Paulose,Nadappuram B
AU - Ivanov,A
AU - Edel,JB
DO - 10.1021/acs.nanolett.9b05307
EP - 2019
PY - 2020///
SN - 1530-6984
SP - 2012
TI - Individually addressable multi-nanopores for single-molecule targeted operations
T2 - Nano Letters
UR - http://dx.doi.org/10.1021/acs.nanolett.9b05307
UR - https://pubs.acs.org/doi/10.1021/acs.nanolett.9b05307
UR - http://hdl.handle.net/10044/1/76775
VL - 20
ER -