Imperial College London
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Professor Joshua B. Edel

Faculty of Natural Sciences, Department of Chemistry

Professor of Biosensing & Analytical Sciences
 
 
 
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Contact

 

+44 (0)20 7594 0754joshua.edel Website

 
 
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Assistant

 

Mr John Murrell +44 (0)20 7594 2845

 
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Location

 

110cMolecular Sciences Research HubWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@inproceedings{Kang:2015,
author = {Kang, DK and Gong, X and Cho, S and Kim, JY and Edel, J and Chang, SI and Choo, J and De, Mello AJ},
pages = {897--899},
title = {3D droplet microfluidic system for high-throughput biological assay},
year = {2015}
}
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RIS format (EndNote, RefMan)

TY  - CPAPER
AB  - Herein, we describe the development of a multilayer droplet microfluidic system for creating concentration gradients and generating microdroplets of varying composition for high-throughput biochemical and cell-based screening applications. The 3D droplet-based microfluidic device consists of multiple PDMS layers, which are used to generate logarithmic concentration gradient reagent profiles. Parallel flow focusing structures are used to form picoliter-sized droplets of defined volumes but of varying composition. As proof of concept, we demonstrate rapid enzymatic activity assays and drug cytotoxicity assays on bacteria. The 3D droplet-based microfluidic platform has the potential to allow for high-efficiency and high-throughput analysis, overcoming the structural limitations of single layer microfluidic systems.
AU  - Kang,DK
AU  - Gong,X
AU  - Cho,S
AU  - Kim,JY
AU  - Edel,J
AU  - Chang,SI
AU  - Choo,J
AU  - De,Mello AJ
EP  - 899
PY  - 2015///
SP  - 897
TI  - 3D droplet microfluidic system for high-throughput biological assay
ER  -
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