Imperial College London

Professor Joshua B. Edel

Faculty of Natural SciencesDepartment of Chemistry

Professor of Biosensing & Analytical Sciences
 
 
 
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Contact

 

+44 (0)20 7594 0754joshua.edel Website

 
 
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Assistant

 

Mrs Althea Hartley-Forbes +44 (0)20 7594 5717

 
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Location

 

442AChemistrySouth Kensington Campus

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Summary

 

Summary

In order to find out more about my research activities or to find out about openings, please visit my group website:  http://www3.imperial.ac.uk/edelgroup

Joshua's research publications can be found at the tab above, or on GoogleScholar


Research Interests

Analytical Sensors plays a crucial role in today’s highly demanding exploration and development of new detection strategies. Whether it be medicine, biochemistry, bioengineering, or analytical chemistry the goals are essentially the same: 1) improve selectivity & sensitivity, 2) maximize throughput, 3) and reduce the instrumental footprint. In order to address these key challenges, the analytical community has borrowed technologies and design philosophies which has been used by the semiconductor industry over the past 20 years. By doing so, key technological advances have been made which include the miniaturization of sensors and signal processing components which allows for the efficient detection of nanoscale object. One can imagine that by decreasing the dimensions of a sensor to a scale similar to that of a nanoscale object, the ultimate in sensitivity can potentially be achieved - the detection of single molecules.

Current research activities taking place in the group include:

  • Single molecule biological screening using electrical and optical methods
  • Early stage diagnostics including cancer and neurodegenerative disorders
  • Single cell screening
  • Development of novel DNA sequencing and nanopore platforms
  • Electrovariable plasmonics
  • Microfluidics including artery on a chip

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Biography

Prof. Joshua Edel received his PhD on the development of single molecule detection within microfluidic systems at Imperial College London in 2003. He then performed postdoctoral research in nanobiotechnology at Cornell University within the School of Applied and Engineering Physics. In 2005 he was awarded a research fellowship in single molecule biophysics at the Rowland Institute at Harvard University. In July 2006 he joined Imperial College London within the Department of Chemistry and Institute of Biomedical Engineering as a lecturer. Joshua is currently a Professor in the Department of Chemistry and in 2011 he was awarded a prestigious ERC Starting Grant on “Nanoporous Membranes for High Throughput Rare Event Bioanalysis” and in 2016 he was awarded an ERC Consolidator Grant related to the development of selective single molecule biosensors.


Selected Publications

Journal Articles

Al Sulaiman D, Cadinu P, Ivanov AP, et al., 2018, Chemically Modified Hydrogel-Filled Nanopores: A Tunable Platform for Single-Molecule Sensing, Nano Letters, Vol:18, ISSN:1530-6984, Pages:6084-6093

Cadinu P, Campolo G, Pud S, et al., 2018, Double Barrel Nanopores as a New Tool for Controlling Single-Molecule Transport, Nano Letters, Vol:18, ISSN:1530-6984, Pages:2738-2745

Barik A, Zhang Y, Grassi R, et al., 2017, Graphene-edge dielectrophoretic tweezers for trapping of biomolecules, Nature Communications, Vol:8, ISSN:2041-1723

Sze JYY, Ivanov AP, Cass AEG, et al., 2017, Single molecule multiplexed nanopore protein screening in human serum using aptamer modified DNA carriers, Nature Communications, Vol:8, ISSN:2041-1723

Montelongo Y, Sikdar D, Ma Y, et al., 2017, Electrotunable nanoplasmonic liquid mirror., Nature Materials, Vol:16, ISSN:1476-1122, Pages:1127-1135

Cadinu P, Paulose Nadappuram B, Lee DJ, et al., 2017, Single Molecule Trapping and Sensing Using Dual Nanopores Separated by a Zeptoliter Nanobridge., Nano Letters, Vol:17, ISSN:1530-6984, Pages:6376-6384

Ren R, Zhang Y, Nadappuram BP, et al., 2017, Nanopore extended field-effect transistor for selective single-molecule biosensing, Nature Communications, Vol:8, ISSN:2041-1723

More Publications