Imperial College London

Professor Josip Car

Faculty of MedicineSchool of Public Health

Visiting Professor
 
 
 
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Contact

 

+44 (0)20 7594 0799josip.car Website

 
 
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Location

 

326Reynolds BuildingCharing Cross Campus

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Summary

 

Publications

Publication Type
Year
to

540 results found

Lum E, Jimenez G, Huang Z, Linh T, Car Jet al., 2020, Appropriateness of action prompts for hypoglycaemia and hyperglycaemia in type 2 diabetes self-management apps, Diabetes - Metabolism: Research and Reviews, Vol: 36, Pages: 1-6, ISSN: 1520-7552

BackgroundControl of blood glucose levels is needed not only to alleviate symptoms of hypoglycaemia and hyperglycaemia, but also to prevent or delay diabetes‐related complications. Advice for glucose control is usually provided to patients by members of the health care team. However, many diabetes apps claim to enhance self‐management of blood glucose by providing decision support to patients when an out‐of‐range blood glucose level is recorded. In this study, we investigated the appropriateness of action prompts provided by diabetes apps for hypoglycaemia and hyperglycaemia against evidence‐based guidelines.MethodsWe used methods previously reported to identify and select diabetes apps, which were downloaded and assessed against the American Diabetes Association (ADA) guidelines. Screenshots of action prompts corresponding to low or high out‐of‐range blood glucose values were subjected to content analysis.ResultsOf 371 diabetes self‐management apps evaluated, only 217 and 216 apps alerted patients about hypoglycaemia and hyperglycaemia, respectively. Of these, 20.7% (45/217) and 15.3% (33/216) also provided action prompts. We found 5.1% of apps (hypoglycaemia: 11/217; hyperglycaemia: 11/216) provided prompts that were either too general to be helpful or not aligned with ADA guidelines. Overall, only 17.9% (39/217) and 14.8% (32/216) provided appropriate action prompts for hypoglycaemia and hyperglycaemia, respectively.ConclusionLess than one fifth of apps provided evidence‐based steps to guide patients through hypoglycaemia and hyperglycaemia. The majority of apps failed to provide just‐in‐time diabetes self‐management education to prevent frequent or severe episodes of hypoglycaemia and hyperglycaemia. Our findings emphasize the need for better design and quality assurance of diabetes apps.

Journal article

Rykov Y, Thuan-Quoc T, Dunleavy G, Roberts AC, Christopoulos G, Soh C-K, Car Jet al., 2020, Activity Tracker-Based Metrics as Digital Markers of Cardiometabolic Health in Working Adults: Cross-Sectional Study, JMIR MHEALTH AND UHEALTH, Vol: 8, ISSN: 2291-5222

Journal article

Kinyoki DK, Osgood-Zimmerman AE, Pickering BV, Schaeffer LE, Marczak LB, Lazzar-Atwood A, Collison ML, Henry NJ, Abebe Z, Adamu AA, Adekanmbi V, Ahmadi K, Ajumobi O, Al-Eyadhy A, Al-Raddadi RM, Alahdab F, Alijanzadeh M, Alipour V, Altirkawi K, Amini S, Andrei CL, Antonio CAT, Arabloo J, Aremu O, Asadi-Aliabadi M, Atique S, Ausloos M, Avila M, Awasthi A, Ayala Quintanilla BP, Azari S, Badawi A, Baernighausen TW, Bassat Q, Baye K, Bedi N, Bekele BB, Bell ML, Bhattacharjee NV, Bhattacharyya K, Bhattarai S, Bhutta ZA, Biadgo B, Bikbov B, Briko AN, Britton G, Burstein R, Butt ZA, Car J, Castaneda-Orjuela CA, Castro F, Cerin E, Chipeta MG, Chu D-T, Cork MA, Cromwell EA, Cuevas-Nasu L, Dandona L, Dandona R, Daoud F, Das Gupta R, Weaver ND, De Leo D, De Neve J-W, Deribe K, Desalegn BB, Deshpande A, Desta M, Diaz D, Tadese Dinberu M, Doku DT, Dubey M, Duraes AR, Dwyer-Lindgren L, Earl L, Effiong A, Zaki MES, El Tantawi M, El-Khatib Z, Eshrati B, Fareed M, Faro A, Fereshtehnejad S-M, Filip I, Fischer F, Foigt NA, Folayan MO, Fukumoto T, Gebrehiwot TT, Gezae KE, Ghajar A, Gill PS, Gona PN, Gopalani SV, Grada A, Guo Y, Haj-Mirzaian A, Haj-Mirzaian A, Hall JB, Hamidi S, Henok A, Prado BH, Herrero M, Herteliu C, Hoang CL, Hole MK, Hossain N, Hosseinzadeh M, Hu G, Islam SMS, Jakovljevic M, Jha RP, Jonas JB, Jozwiak JJ, Kahsay A, Kanchan T, Karami M, Kasaeian A, Khader YS, Khan EA, Khater MM, Kim YJ, Kimokoti RW, Kisa A, Kochhar S, Kosen S, Koyanagi A, Krishan K, Defo BK, Kumar GA, Kumar M, Lad SD, Lami FH, Lee PH, Levine AJ, Li S, Linn S, Lodha R, Abd El Razek HM, Abd El Razek MM, Majdan M, Majeed A, Malekzadeh R, Malta DC, Mamun AA, Mansournia MA, Martins-Melo FR, Masaka A, Massenburg BB, Mayala BK, Mejia-Rodriguez F, Melku M, Mendoza W, Mensah GA, Miazgowski T, Miller TR, Mini GK, Mirrakhimov EM, Moazen B, Darwesh AM, Mohammed S, Mohebi F, Mokdad AH, Moodley Y, Moradi G, Moradi-Lakeh M, Moraga P, Morrison SD, Mosser JF, Mousavi SM, Mueller UO, Murray CJL, Mustafa G, Naderi M, Naet al., 2020, Mapping child growth failure across low- and middle-income countries, Nature, Vol: 577, Pages: 231-234, ISSN: 0028-0836

Childhood malnutrition is associated with high morbidity and mortality globally1. Undernourished children are more likely to experience cognitive, physical, and metabolic developmental impairments that can lead to later cardiovascular disease, reduced intellectual ability and school attainment, and reduced economic productivity in adulthood2. Child growth failure (CGF), expressed as stunting, wasting, and underweight in children under five years of age (0–59 months), is a specific subset of undernutrition characterized by insufficient height or weight against age-specific growth reference standards3,4,5. The prevalence of stunting, wasting, or underweight in children under five is the proportion of children with a height-for-age, weight-for-height, or weight-for-age z-score, respectively, that is more than two standard deviations below the World Health Organization’s median growth reference standards for a healthy population6. Subnational estimates of CGF report substantial heterogeneity within countries, but are available primarily at the first administrative level (for example, states or provinces)7; the uneven geographical distribution of CGF has motivated further calls for assessments that can match the local scale of many public health programmes8. Building from our previous work mapping CGF in Africa9, here we provide the first, to our knowledge, mapped high-spatial-resolution estimates of CGF indicators from 2000 to 2017 across 105 low- and middle-income countries (LMICs), where 99% of affected children live1, aggregated to policy-relevant first and second (for example, districts or counties) administrative-level units and national levels. Despite remarkable declines over the study period, many LMICs remain far from the ambitious World Health Organization Global Nutrition Targets to reduce stunting by 40% and wasting to less than 5% by 2025. Large disparities in prevalence and progress exist across and within countries; our maps identify high-prev

Journal article

Ho AHY, Dutta O, Tan-Ho G, Tan THB, Low CX, Ganapathy S, Car J, Ho RM-H, Miao CYet al., 2020, A Novel Narrative E-Writing Intervention for Parents of Children With Chronic Life-Threatening Illnesses: Protocol for a Pilot, Open-Label Randomized Controlled Trial (Preprint)

<sec> <title>BACKGROUND</title> <p>A novel evidence-based Narrative e-Writing Intervention (NeW-I) has been developed and tested in Singapore to advance psychosociospiritual support for parents of children with chronic life-threatening illnesses. NeW-I is informed by an international systematic review and a Singapore-based qualitative inquiry on the lived experience of parental bereavement and supported by literature on anticipatory grief interventions for improving the holistic well-being of parent caregivers of seriously ill children.</p> </sec> <sec> <title>OBJECTIVE</title> <p>This study's aim was to provide an accessible platform, NeW-I—which is a strengths- and meaning-focused and therapist-facilitated mobile app and web-based counseling platform—that aims to enhance quality of life, spiritual well-being, hope, and perceived social support and reduce depressive symptoms, caregiver burden, and risk of complicated grief among parents of children with chronic life-threatening illnesses.</p> </sec> <sec> <title>METHODS</title> <p>The NeW-I therapist-facilitated web-based platform comprises a mobile app and a website (both of which have the same contentand functionality). NeW-I has been implemented in Singapore as a pilot open-label randomized controlled trial comprising intervention and control groups. Both primary and secondary outcomes will be self-reported by participants through questionnaires. In collaboration with leading pediatric palliative care providers in Singapore, the trial aims to enroll 36 participants in each group (N=72), so that when allowing for 30% attrition at follow-up, the sample size will be adequate to detect a small ef

Journal article

Troeger CE, Khalil IA, Blacker BF, Biehl MH, Albertson SB, Zimsen SRM, Rao PC, Abate D, Admasie A, Ahmadi A, Ahmed MLCB, Akal CG, Alahdab F, Alam N, Alene KA, Alipour V, Aljunid SM, Al-Raddadi RM, Alvis-Guzman N, Amini S, Anjomshoa M, Antonio CAT, Arabloo J, Aremu O, Atalay HT, Atique S, Avokpaho EFGA, Awad S, Awasthi A, Badawi A, Balakrishnan K, Banoub JAM, Barac A, Bassat Q, Bedi N, Bennett DA, Bhattacharyya K, Bhutta ZA, Bijani A, Bills CB, Car J, Carvalho F, Castaneda-Orjuela CA, Causey K, Christopher DJ, Cohen AJ, Dandona L, Dandona R, Daryani A, Demeke FM, Djalalinia S, Dubey M, Dubljanin E, Duken EE, Zaki MES, Endries AY, Fernandes E, Fischer F, Frostad J, Fullman N, Gardner WM, Geta B, Ghadiri K, Gorini G, Goulart AC, Guo Y, Hailu GB, Haj-Mirzaian A, Haj-Mirzaian A, Hamidi S, Hassen HY, Chi LH, Horita N, Hostiuc M, Hussain Z, Irvani SSN, James SL, Jha RP, Jonas JB, Karch A, Kasaeian A, Kassa TD, Kassebaum NJ, Kefale AT, Khader YS, Khan EA, Khan G, Khan MN, Khang Y-H, Khoja AT, Kimokoti RW, Kisa A, Kisa S, Kissoon N, Knibbs LD, Kochhar S, Kosen S, Koul PA, Koyanagi A, Defo BK, Kumar GA, Lal DK, Leshargie CT, Lewycka S, Li S, Lodha R, Macarayan ERK, Majdan M, Mamun AA, Manguerra H, Mehta V, Melese A, Memish ZA, Mengistu DT, Meretoja TJ, Mestrovic T, Miazgowski B, Mirrakhimov EM, Moazen B, Mohammad KA, Mohammed S, Monasta L, Moore CE, Morawska L, Mosser JF, Mousavi SM, Murthy S, Mustafa G, Nazari J, Cuong TN, Huong LTN, Long HN, Son HN, Nielsen KR, Nisar MI, Nixon MR, Ogbo FA, Okoro A, Olagunju AT, Olagunju TO, Oren E, Ortiz JR, Mahesh PA, Pakhale S, Postma MJ, Qorbani M, Quansah R, Rafiei A, Rahim F, Rahimi-Movaghar V, Rai RK, Reitsma MB, Rezai MS, Rezapour A, Jesus Rios-Blancas M, Ronfani L, Rothenbacher D, Rubino S, Saleem Z, Sambala EZ, Samy AM, Milicevic MMS, Sarmiento-Suarez R, Sartorius B, Savic M, Sawhney M, Saxena S, Sbarra A, Seyedmousavi S, Shaikh MA, Sheikh A, Shigematsu M, Smith DL, Sreeramareddy CT, Stanaway JD, Sufiyan MB, Temsah M-H, Tessema Bet al., 2020, Quantifying risks and interventions that have affected the burden of lower respiratory infections among children younger than 5 years: an analysis for the Global Burden of Disease Study 2017, LANCET INFECTIOUS DISEASES, Vol: 20, Pages: 60-79, ISSN: 1473-3099

Journal article

Troeger CE, Khalil IA, Blacker BF, Biehl MH, Albertson SB, Zimsen SRM, Rao PC, Abate D, Ahmadi A, Ahmed MLCB, Akal CG, Alahdab F, Alam N, Alene KA, Alipour V, Aljunid SM, Al-Raddadi RM, Alvis-Guzman N, Amini S, Anber NH, Anjomshoa M, Antonio CAT, Arabloo J, Aremu O, Atalay HT, Atique S, Avokpaho EFGA, Awad S, Awasthi A, Badawi A, Balakrishnan K, Banoub JAM, Barac A, Bassat Q, Bedi N, Bennett DA, Bhattacharyya K, Bhutta ZA, Bijani A, Car J, Carvalho F, Castaneda-Orjuela CA, Christopher DJ, Dandona L, Dandona R, Daryani A, Demeke FM, Deshpande A, Djalalinia S, Dubey M, Dubljanin E, Duken EE, Zaki MES, Endries AY, Fernandes E, Fischer F, Fullman N, Gardner WM, Geta B, Ghadiri K, Gorini G, Goulart AC, Guo Y, Hailu GB, Haj-Mirzaian A, Haj-Mirzaian A, Hamidi S, Hassen HY, Chi LH, Hostiuc M, Hussain Z, Irvani SSN, James SL, Jha RP, Jonas JB, Karch A, Kasaeian A, Kassa TD, Kassebaum NJ, Kefale AT, Khader YS, Khan EA, Khan MN, Khang Y-H, Khoja AT, Kimokoti RW, Kisa A, Kisa S, Kissoon N, Kochhar S, Kosen S, Koyanagi A, Defo BK, Kumar GA, Lal DK, Leshargie CT, Li S, Lodha R, Macarayan ERK, Majdan M, Mamun AA, Manguerra H, Melese A, Memish ZA, Mengistu DT, Meretoja TJ, Mestrovic T, Miazgowski B, Mirrakhimov EM, Moazen B, Mohammad KA, Mohammed S, Monasta L, Moore CE, Mosser JF, Mousavi SM, Murthy S, Mustafa G, Nazari J, Cuong TN, Long HN, Nisar MI, Nixon MR, Ogbo FA, Okoro A, Olagunju AT, Olagunju TO, Mahesh PA, Pakhale S, Postma MJ, Qorbani M, Quansah R, Rafiei A, Rahim F, Rahimi-Movaghar V, Rai RK, Rezai MS, Rezapour A, Jesus Rios-Blancas M, Ronfani L, Rosettie K, Rothenbacher D, Safari S, Saleem Z, Sambala EZ, Samy AM, Milicevic MMS, Sartorius B, Sawhney M, Seyedmousavi S, Shaikh MA, Sheikh A, Shigematsu M, Smith DL, Soriano JB, Sreeramareddy CT, Stanaway JD, Sufiyan MB, Teklu TGE, Temsah M-H, Tessema B, Bach XT, Khanh BT, Ullah I, Updike RL, Vasankari TJ, Veisani Y, Wada FW, Waheed Y, Weaver M, Wiens KE, Wiysonge CS, Yimer EM, Yonemoto N, Zaidi Z, Zar HJ, Zarghi A, Lim SS Vet al., 2020, Quantifying risks and interventions that have affected the burden of diarrhoea among children younger than 5 years: an analysis of the Global Burden of Disease Study 2017, LANCET INFECTIOUS DISEASES, Vol: 20, Pages: 37-59, ISSN: 1473-3099

Journal article

Spinazze P, Rykov Y, Bottle R, Car Jet al., 2019, Digital phenotyping for assessment and prediction of mental health outcomes: A scoping review protocol, BMJ Open, Vol: 9, ISSN: 2044-6055

Introduction: Rapid advancements in technology and the ubiquity of personal mobile digital devices have brought forth innovative methods of acquiring healthcare data. Smartphones can capture vast amounts of data both passively through inbuilt sensors or connected devices and actively via user engagement. This scoping review aims to evaluate evidence to date on the use of passive digital sensing/phenotyping in assessment and prediction of mental health.Methods and analysis: The methodological framework proposed by Arksey and O’Malley will be used to conduct the review following the five-step process. A three-step search strategy will be used: 1. Initial limited search of online databases namely, MEDLINE for literature on digital phenotyping or sensing for key terms; 2. Comprehensive literature search using all identified keywords, across all relevant electronic databases: IEEE Xplore, MEDLINE, the Cochrane Database of Systematic Reviews, PubMed, the ACM Digital Library and Web of Science Core Collection (Science Citation Index Expanded and Social Sciences Citation Index), Scopus; and 3. Snowballing approach using the reference and citing lists of all identified key conceptual papers and primary studies. Data will be charted and sorted using a thematic analysis approach.Ethics and Dissemination: The findings from this systematic scoping review will be reported at scientific meetings and published in a peer-reviewed journal.

Journal article

Divakar U, Sathish T, Soljak M, Bajpai R, Dunleavy G, Visvalingam N, Nazeha N, Soh CK, Christopoulos G, Car Jet al., 2019, Prevalence of vitamin D deficiency and its associated work-related factors among indoor workers in a multi-ethnic Southeast Asian Country, International Journal of Environmental Research and Public Health, Vol: 17, ISSN: 1660-4601

Little is known about the effect of working conditions on vitamin D status in Southeast Asia, where vitamin D deficiency is common despite the presence of sunlight all year round in most places. We examined the prevalence of vitamin D deficiency and its associated work-related factors among indoor workers using the data of 213 participants (aged ≥21 years) from a workplace cohort study in Singapore. Vitamin D deficiency was defined as serum 25-hydroxyvitamin D (25(OH)D) concentration <50 nmol/L. Data on work-related factors, socio-demographic characteristics, and lifestyle habits were collected using standardized questionnaires. Clinical and biochemical measurements were performed using standard tools and protocols. Multivariate Poisson regression was used to examine the independent association of work-related factors with vitamin D deficiency. Mean serum 25(OH)D concentration was 59.6 nmol/L. The prevalence of vitamin D deficiency was 32.9% (95% confidence interval (CI): 26.6-39.6%). In the multivariate analysis, office workers (prevalence ratio (PR): 2.16, 95% CI: 1.12-4.16 versus control room workers), workshop workers (PR: 2.25, 95% CI: 1.05-4.81 versus control room workers), and night shift workers (PR: 1.31, 95% CI: 1.03-1.67) were at a greater risk for vitamin D deficiency. Workplace policies and wellness programs should encourage workers to take regular breaks to go outdoors for sunlight exposure and to consume adequate amounts of vitamin D-rich foods to maintain optimal vitamin D levels.

Journal article

Martinengo L, Van Galen L, Lum E, Kowalski M, Subramaniam M, Car Jet al., 2019, Suicide prevention and depression apps' suicide risk assessment and management: a systematic assessment of adherence to clinical guidelines, BMC Medicine, Vol: 17, ISSN: 1741-7015

BACKGROUND: There are an estimated 800,000 suicides per year globally, and approximately 16,000,000 suicide attempts. Mobile apps may help address the unmet needs of people at risk. We assessed adherence of suicide prevention advice in depression management and suicide prevention apps to six evidence-based clinical guideline recommendations: mood and suicidal thought tracking, safety plan development, recommendation of activities to deter suicidal thoughts, information and education, access to support networks, and access to emergency counseling. METHODS: A systematic assessment of depression and suicide prevention apps available in Google Play and Apple's App Store was conducted. Apps were identified by searching 42matters in January 2019 for apps launched or updated since January 2017 using the terms "depression," "depressed," "depress," "mood disorders," "suicide," and "self-harm." General characteristics of apps, adherence with six suicide prevention strategies identified in evidence-based clinical guidelines using a 50-question checklist developed by the study team, and trustworthiness of the app based on HONcode principles were appraised and reported as a narrative review, using descriptive statistics. RESULTS: The initial search yielded 2690 potentially relevant apps. Sixty-nine apps met inclusion criteria and were systematically assessed. There were 20 depression management apps (29%), 3 (4%) depression management and suicide prevention apps, and 46 (67%) suicide prevention apps. Eight (12%) depression management apps were chatbots. Only 5/69 apps (7%) incorporated all six suicide prevention strategies. Six apps (6/69, 9%), including two apps available in both app stores and downloaded more than one million times each, provided an erroneous crisis helpline number. Most apps included emergency contact information (65/69 apps, 94%) and direct access to a crisis helpline through the app (46/69 app

Journal article

Visvalingam N, Sathish T, Soljak M, Ping CA, Dunleavy G, Divakar U, Nazeha N, Bajpai R, Soh CK, Woon KK, Christopoulos G, Car Jet al., 2019, Prevalence of and factors associated with poor sleep quality and short sleep in a working population in Singapore, Sleep Health, ISSN: 2352-7218

ObjectivesWe aimed to examine the prevalence of poor sleep quality and short sleep and their associated factors in a working population in Singapore.DesignThis is a cross-sectional analysis.SettingFour companies in Singapore were included in this study.ParticipantsParticipants included 464 full-time employees (aged ≥21 years).MeasurementsSelf-reported sleep quality was assessed using the Pittsburgh Sleep Quality Index (PSQI). Self-administered questionnaires were used to collect data on sociodemographic characteristics, health behaviours, medical history, chronotype, psychosocial factors, health-related quality of life (HRQoL) and occupational factors. Clinical measurements were performed using standard tools and protocols. Multivariate logistic regression was used to examine the factors associated with poor sleep quality (PSQI global score >5) and short sleep (<7 hours/night).ResultsThe mean age was 39.0 (SD: 11.4) years, and 79.5% were men. The prevalence of poor sleep quality was 42.5%, and 66.2% were short sleepers. Nearly three-fourths (71.3%) had at least one of these two conditions. Age, Malay ethnicity (vs. Chinese), chronic conditions, poorer mental health, stress at home or work and shift work were positively associated, and mental component summary of the HRQoL scale and work years in the current company were negatively associated with poor sleep quality. Age, Malay and Indian ethnicities (vs. Chinese), longer dinner-to-bed time, snacking between dinner and bed time, and poorer mental health were positively associated with short sleep.ConclusionsPoor sleep quality and short sleep were highly common in this working population in Singapore. Workplace policies should include education and intervention programmes to promote better sleep hygiene.

Journal article

Paranjape K, Schinkel M, Nannan Panday R, Car J, Nanayakkara Pet al., 2019, Introducing Artificial Intelligence Training in Medical Education., JMIR Med Educ, Vol: 5, ISSN: 2369-3762

Health care is evolving and with it the need to reform medical education. As the practice of medicine enters the age of artificial intelligence (AI), the use of data to improve clinical decision making will grow, pushing the need for skillful medicine-machine interaction. As the rate of medical knowledge grows, technologies such as AI are needed to enable health care professionals to effectively use this knowledge to practice medicine. Medical professionals need to be adequately trained in this new technology, its advantages to improve cost, quality, and access to health care, and its shortfalls such as transparency and liability. AI needs to be seamlessly integrated across different aspects of the curriculum. In this paper, we have addressed the state of medical education at present and have recommended a framework on how to evolve the medical education curriculum to include AI.

Journal article

Thuan-Quoc T, Mahirah D, Dunleavy G, Nazeha N, Zhang Y, Tan CEH, Roberts AC, Christopoulos G, Soh CK, Car Jet al., 2019, Prevalence of sick building syndrome and its association with perceived indoor environmental quality in an Asian multi-ethnic working population, BUILDING AND ENVIRONMENT, Vol: 166, ISSN: 0360-1323

Journal article

Dunleavy G, Bajpai R, Tonon AC, Chua AP, Cheung KL, Soh C-K, Christopoulos G, de Vries H, Car Jet al., 2019, Examining the Factor Structure of the Pittsburgh Sleep Quality Index in a Multi-Ethnic Working Population in Singapore, INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, Vol: 16

Journal article

Ho AHY, Dutta O, Tan-Ho G, Tan THB, Xinyi CL, Ganapathy S, Ang LB, Car J, Ho RM-H, Miao CYet al., 2019, A Novel Narrative E-Writing Intervention (NeW-I) for Parents of Children with Chronic Life-Threatening Illnesses: Protocol for an Open-Label Randomized Controlled Trial

<jats:title>Abstract</jats:title> <jats:p>The authors have withdrawn this preprint from Research Square</jats:p>

Journal article

Sathish T, Dunleavy G, Soljak M, Visvalingam N, Nazeha N, Divakar U, Bajpai R, Thuan-Quoc T, Cheung KL, de Vries H, Soh C-K, Christopoulos G, Car Jet al., 2019, Risk factors for non-communicable diseases at baseline and their short-Term changes in a workplace cohort in Singapore, International Journal of Environmental Research and Public Health, Vol: 16, Pages: 1-11, ISSN: 1660-4601

We aimed to examine the behavioural and clinical risk factors for non-communicable diseases (NCDs) at baseline and their changes over 12 months in a workplace cohort in Singapore. A total of 464 full-time employees (age ≥ 21 years) were recruited from a variety of occupational settings, including offices, control rooms, and workshops. Of these, 424 (91.4%) were followed-up at three months and 334 (72.0%) were followed up at 12 months. Standardized questionnaires were used to collect data on health behaviours and clinical measurements were performed by trained staff using standard instruments and protocols. Age-adjusted changes in risk factors over time were examined using generalized estimating equations or linear mixed-effects models where appropriate. The mean age of the participants at baseline was 39.0 (SD: 11.4) years and 79.5% were men. Nearly a quarter (24.4%) were current smokers, slightly more than half (53.5%) were alcohol drinkers, two-thirds (66%) were consuming <5 servings of fruit and vegetables per day, and 23.1% were physically inactive. More than two-thirds (67%) were overweight or obese and 34.5% had central obesity. The mean follow-up was 8.6 months. After adjusting for age, over 12 months, there was a significant increase in the proportion consuming <5 servings of fruit and vegetables per day by 33% (p = 0.030), who were physically inactive by 64% (p < 0.001), and of overweight or obese people by 15% (p = 0.018). The burden of several key NCD risk factors at baseline was high and some worsened within a short period of time in this working population. There is a need for more targeted strategies for behaviour change towards a healthy lifestyle as part of the ongoing health and wellness programs at workplaces in Singapore. View Full-Text

Journal article

Xu X, van Galen LS, Koh MJA, Bajpai R, Thng S, Yew YW, Ho VP, Alagappan U, Jarbrink KSA, Car Jet al., 2019, Factors influencing quality of life in children with atopic dermatitis and their caregivers: a cross-sectional study, Scientific Reports, Vol: 9, ISSN: 2045-2322

Better understanding of atopic dermatitis’ effect on quality of life could enhance current management and therapeutic strategies. Studies investigating factors related to the health-related quality of life (HRQOL) of children with atopic dermatitis and their caregivers are limited. This cross-sectional study included 559 children (<16 years) with atopic dermatitis and their caregivers. Disease severity was associated with infants’ HRQOL (moderate: IRR: 1.42, 95% CI 1.20–1.67; severe: IRR: 1.72, 95% CI 1.32–2.24). Age and disease severity were associated with children’s HRQOL (age: IRR: 0.99, 95% CI 0.98–1.00; moderate: IRR: 1.08, 95% CI 1.02–1.14). Quality of life subdomains itching/scratching, emotional distress and sleep disturbance were most reported and increased with higher disease severity. Both caregivers’ mental and physical health were negatively affected by children’s HRQOL (physical: IRR: 0.99, 95% CI 0.99–1.00; mental: IRR: 0.98, 95% CI 0.97–0.99). Sociodemographic characteristics (gender, ethnicity, educational attainment of carers, number of children) did not demonstrate significance in children’s HRQOL model. In conclusion, current atopic dermatitis diagnostics and treatment have to be extended to the factors influencing both children’ as their caregivers’ quality of life and adapting management accordingly. Itching/scratching, emotional distress and sleep disturbance deserve attention. Sociodemographic characteristics in children’s HRQOL models also merit attention in further research.

Journal article

Xu X, Griva K, Koh M, Lum E, Tan WS, Thng S, Car Jet al., 2019, Creating a Smartphone App for Caregivers of Children With Atopic Dermatitis With Caregivers, Health Care Professionals, and Digital Health Experts: Participatory Co-Design (Preprint)

<sec> <title>BACKGROUND</title> <p>Smartphone apps could support patients and caregivers in disease self-management. However, as patients’ experiences and needs might not always align with clinical judgments, the eliciting and engaging of perspectives of all stakeholders in the smartphone app design process is of paramount importance.</p> </sec> <sec> <title>OBJECTIVE</title> <p>The aims of this study are to better understand the needs of and challenges facing caregivers and health care professionals (HCPs) who care for children with atopic dermatitis (AD) and to explore the desirable features and content of a smartphone app that would support AD self-management.</p> </sec> <sec> <title>METHODS</title> <p>This study adopted a qualitative participatory co-design methodology involving 3 focus group discussions: workshop one focused on caregivers; workshop two engaged with HCPs; and in the last workshop, caregivers and digital health experts were asked to design the wireframe prototype. The participants completed a sociodemographic questionnaire, a technology acceptance questionnaire, and a workshop evaluation form.</p> </sec> <sec> <title>RESULTS</title> <p>Twelve caregivers participated in the first workshop, and 10 HCPs participated in the second workshop. Eight caregivers and 4 digital health experts attended the third workshop. Three superordinate themes that reflected caregivers’ and HCPs’ challenges and needs were identified: &lt;i&gt;empowerment by education, confusion over treatment&lt;/i&gt;, and

Journal article

Dunleavy G, Tonon AC, Chua AP, Zhang Y, Cheung KL, Thuan-Quoc T, Rykov Y, Soh C-K, Christopoulos G, de Vries H, Car Jet al., 2019, A Multifactorial Approach to Sleep and Its Association with Health-Related Quality of Life in a Multiethnic Asian Working Population: A Cross-Sectional Analysis, INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, Vol: 16, ISSN: 1661-7827

Journal article

Burstein R, Henry NJ, Collison ML, Marczak LB, Sligar A, Watson S, Marquez N, Abbasalizad-Farhangi M, Abbasi M, Abd-Allah F, Abdoli A, Abdollahi M, Abdollahpour I, Abdulkader RS, Abrigo MRM, Acharya D, Adebayo OM, Adekanmbi V, Adham D, Afshari M, Aghaali M, Ahmadi K, Ahmadi M, Ahmadpour E, Ahmed R, Akal CG, Akinyemi JO, Alahdab F, Alam N, Alamene GM, Alene KA, Alijanzadeh M, Alinia C, Alipour V, Aljunid SM, Almalki MJ, Al-Mekhlafi HM, Altirkawi K, Alvis-Guzman N, Amegah AK, Amini S, Amit AML, Anbari Z, Androudi S, Anjomshoa M, Ansari F, Antonio CAT, Arabloo J, Arefi Z, Aremu O, Armoon B, Arora A, Artaman A, Asadi A, Asadi-Aliabadi M, Ashraf-Ganjouei A, Assadi R, Ataeinia B, Atre SR, Quintanilla BPA, Ayanore MA, Azari S, Babaee E, Babazadeh A, Badawi A, Bagheri S, Bagherzadeh M, Baheiraei N, Balouchi A, Barac A, Bassat Q, Baune BT, Bayati M, Bedi N, Beghi E, Behzadifar M, Behzadifar M, Belay YB, Bell B, Bell ML, Berbada DA, Bernstein RS, Bhattacharjee NV, Bhattarai S, Bhutta ZA, Bijani A, Bohlouli S, Breitborde NJK, Britton G, Browne AJ, Nagaraja SB, Busse R, Butt ZA, Car J, Cárdenas R, Castañeda-Orjuela CA, Cerin E, Chanie WF, Chatterjee P, Chu D-T, Cooper C, Costa VM, Dalal K, Dandona L, Dandona R, Daoud F, Daryani A, Das Gupta R, Davis I, Davis Weaver N, Davitoiu DV, De Neve J-W, Demeke FM, Demoz GT, Deribe K, Desai R, Deshpande A, Desyibelew HD, Dey S, Dharmaratne SD, Dhimal M, Diaz D, Doshmangir L, Duraes AR, Dwyer-Lindgren L, Earl L, Ebrahimi R, Ebrahimpour S, Effiong A, Eftekhari A, Ehsani-Chimeh E, El Sayed I, El Sayed Zaki M, El Tantawi M, El-Khatib Z, Emamian MH, Enany S, Eskandarieh S, Eyawo O, Ezalarab M, Faramarzi M, Fareed M, Faridnia R, Faro A, Fazaeli AA, Fazlzadeh M, Fentahun N, Fereshtehnejad S-M, Fernandes JC, Filip I, Fischer F, Foigt NA, Foroutan M, Francis JM, Fukumoto T, Fullman N, Gallus S, Gebre DG, Gebrehiwot TT, Gebremeskel GG, Gessner BD, Geta B, Gething PW, Ghadimi R, Ghadiri K, Ghajarzadeh M, Ghashghaee A, Gill PS, Gill TK, Golding N, Goet al., 2019, Mapping 123 million neonatal, infant and child deaths between 2000 and 2017, Nature, Vol: 574, Pages: 353-358, ISSN: 0028-0836

Since 2000, many countries have achieved considerable success in improving child survival, but localized progress remains unclear. To inform efforts towards United Nations Sustainable Development Goal 3.2-to end preventable child deaths by 2030-we need consistently estimated data at the subnational level regarding child mortality rates and trends. Here we quantified, for the period 2000-2017, the subnational variation in mortality rates and number of deaths of neonates, infants and children under 5 years of age within 99 low- and middle-income countries using a geostatistical survival model. We estimated that 32% of children under 5 in these countries lived in districts that had attained rates of 25 or fewer child deaths per 1,000 live births by 2017, and that 58% of child deaths between 2000 and 2017 in these countries could have been averted in the absence of geographical inequality. This study enables the identification of high-mortality clusters, patterns of progress and geographical inequalities to inform appropriate investments and implementations that will help to improve the health of all populations.

Journal article

van der Kleij RMJJ, Kasteleyn MJ, Meijer E, Bonten TN, Houwink IJF, Teichert M, van Luenen S, Vedanthan R, Evers A, Car J, Pinnock H, Chavannes NHet al., 2019, SERIES: eHealth in primary care. Part 1: Concepts, conditions and challenges, EUROPEAN JOURNAL OF GENERAL PRACTICE, Vol: 25, Pages: 179-189, ISSN: 1381-4788

Journal article

Kyaw BM, Car LT, van Galen LS, van Agtmael MA, Costelloe CE, Ajuebor O, Campbell J, Car Jet al., 2019, Health Professions Digital Education on Antibiotic Management: Systematic Review and Meta-Analysis by the Digital Health Education Collaboration, JOURNAL OF MEDICAL INTERNET RESEARCH, Vol: 21, ISSN: 1438-8871

Journal article

Huang Z, Tan E, Lum E, Sloot P, Boehm BO, Car Jet al., 2019, A Smartphone App to Improve Medication Adherence in Patients With Type 2 Diabetes in Asia: Feasibility Randomized Controlled Trial, JMIR MHEALTH AND UHEALTH, Vol: 7, ISSN: 2291-5222

Journal article

Paranjape K, Schinkel M, Nannan Panday R, Car J, Nanayakkara Pet al., 2019, Introducing Artificial Intelligence Training in Medical Education (Preprint)

<sec> <title>UNSTRUCTURED</title> <p>Health care is evolving and with it the need to reform medical education. As the practice of medicine enters the age of artificial intelligence (AI), the use of data to improve clinical decision making will grow, pushing the need for skillful medicine-machine interaction. As the rate of medical knowledge grows, technologies such as AI are needed to enable health care professionals to effectively use this knowledge to practice medicine. Medical professionals need to be adequately trained in this new technology, its advantages to improve cost, quality, and access to health care, and its shortfalls such as transparency and liability. AI needs to be seamlessly integrated across different aspects of the curriculum. In this paper, we have addressed the state of medical education at present and have recommended a framework on how to evolve the medical education curriculum to include AI.</p> </sec>

Journal article

Kyaw BM, Posadzki P, Paddock S, Car J, Campbell J, Car LTet al., 2019, Effectiveness of Digital Education on Communication Skills Among Medical Students: Systematic Review and Meta-Analysis by the Digital Health Education Collaboration, JOURNAL OF MEDICAL INTERNET RESEARCH, Vol: 21, ISSN: 1438-8871

Journal article

Dunleavy G, Sathish T, Nazeha N, Soljak M, Visvalingam N, Bajpai R, Yap HS, Roberts AC, Quoc TT, Tonon AC, Christopoulos G, Soh C-K, Cheung KL, de Vries H, Car Jet al., 2019, Health Effects of Underground Workspaces (HEUW) cohort in Singapore: study design and baseline characteristics, Epidemiology and Health, Vol: 41, ISSN: 2092-7193

The development of underground workspaces is a strategic effort towards healthy urban growth in ever-increasing land-scarce cities. Despite the growth in underground workspaces, there is limited information regarding the impact of this environment on worker’s health. The Health Effects of Underground Workspaces (HEUW) study is a cohort study which was set up to examine the health effects of working in underground workspaces. In this paper, we describe the rationale for the study, study design, data collection and baseline characteristics of participants. The HEUW study recruited 464 participants at baseline, of which 424 (91.4%) were followed-up at three months, and 334 (72.0%) after 12 months from baseline. We used standardized and validated questionnaires to collect information on socio-demographic and lifestyle characteristics, medical history, family history of chronic diseases, sleep quality, health-related quality of life, chronotype, psychological distress, occupational factors, and comfort levels with indoor environmental quality parameters. Clinical and anthropometric parameters including blood pressure, spirometry, height, weight, waist and hip circumference were also measured. Biochemical tests of participant’s blood and urine samples were conducted to measure glucose, lipids and melatonin levels. We also conducted objective measurements of an individual’s workplace environment, assessing air quality, light intensity, temperature, thermal comfort, bacterial and fungal counts. Findings from this study will help to identify modifiable lifestyle and environmental parameters that are negatively affecting worker’s health. The findings may be used to guide the development of more health-promoting workspaces that attempt to negate any potential negative health effects from working in underground workspaces.

Journal article

Spinazze P, Bottle A, Car J, 2019, Digital health sensing for personalized dermatology, Sensors, Vol: 19, Pages: 1-4, ISSN: 1424-2818

The rapid evolution of technology, sensors and personal digital devices offers an opportunity to acquire health related data seamlessly, unobtrusively and in real time. In this opinion piece, we discuss the relevance and opportunities for using digital sensing in dermatology, taking eczema as an exemplar.

Journal article

Meinert E, Alturkistani A, Murray KA, Sabatier P, Car Jet al., 2019, A case study examining the cost measurements in production and delivery of a massive open online course (MOOC) for teaching the relationship between human health and climate change, International Conference on e-Learning 2019, Publisher: IADIS Press, Pages: 1-1

A Massive Open Online Course (MOOC) is a form of online education that makes available learning to a large number of individuals at no charge. The impact of climate change on public health has been introduced in MOOCs in various forms, for example, examining the impact of natural disasters, the increase in temperature on work productivity, and the monitoring and evaluation of health adaptation to climate change and its implications for policy. However, despite this work completed to advance understanding in both online and postgraduate education, more effort is required to provide the tools and capabilities to analyse evidence and present findings that demonstrate its impact on specific outcomes, including health and wellbeing. Although these courses are made publicly available, understanding the costs associated with their production and delivery will provide evidence to develop sustainable models for deployment of this form of citizen engagement education.

Conference paper

Huang Z, Lum E, Jimenez G, Semwal M, Sloot P, Car Jet al., 2019, Medication management support in diabetes: a systematic assessment of diabetes self-management apps, BMC MEDICINE, Vol: 17, ISSN: 1741-7015

Journal article

Car J, Sheikh A, Wicks P, Williams MSet al., 2019, Beyond the hype of big data and artificial intelligence: building foundations for knowledge and wisdom, BMC MEDICINE, Vol: 17, ISSN: 1741-7015

Journal article

Huang Z, Lum E, Car J, 2019, Medication management apps for diabetes: A systematic assessment of the transparency and reliability of health information dissemination (Preprint)

<sec> <title>BACKGROUND</title> <p>Smartphone apps are increasingly used for disease management but the transparency and reliability of information sources for these apps are unclear.</p> </sec> <sec> <title>OBJECTIVE</title> <p>As part of a larger study investigating medication management features of diabetes apps, this study aimed to assess the transparency and reliability of information disseminated via these apps against eight criteria adapted from the Health On the Net (HONcode) principles.</p> </sec> <sec> <title>METHODS</title> <p>English language diabetes-related terms were searched on a market explorer (42matters) on 12 June 2018. Apps with both medication and blood glucose management features were downloaded and evaluated against the app-HONcode criteria adapted from the eight HONcode principles: Authoritative, Complementarity, Privacy, Attribution, Justifiability, Transparency, Financial disclosure, and Advertising policy. Apps were profiled by operating platforms (i.e. Android, iOS) and number of downloads (i.e. Android only: &gt;100,000 downloads, &lt;100,000 downloads).</p> </sec> <sec> <title>RESULTS</title> <p>143 apps (81 Android, 62 iOS) were downloaded and assessed against the adapted App-HONcode criteria. Most of the apps on both the Android and iOS platforms fulfilled between two to six criteria but very few apps mentioned the qualifications of individuals who contributed to app development (14.0%, 20/143). A higher proportion of iOS apps fulfilled six or more App-HONcode criteria compared with Android apps.

Journal article

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