Imperial College London
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ProfessorJulianJones

Faculty of Engineering, Department of Materials

Professor of Biomaterials
 
 
 
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Contact

 

+44 (0)20 7594 6749julian.r.jones

 
 
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Location

 

207GoldsmithSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Turner:2023:10.1016/j.actbio.2023.09.012,
author = {Turner, J and Nandakumar, A and Anilbhai, N and Boccaccini, AR and Jones, JR and Jell, G},
doi = {10.1016/j.actbio.2023.09.012},
journal = {Acta Biomater},
pages = {39--52},
title = {The effect of Si species released from bioactive glasses on cell behaviour: A quantitative review.},
url = {http://dx.doi.org/10.1016/j.actbio.2023.09.012},
volume = {170},
year = {2023}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Despite over 50 years of silicate bioactive glass (SBG) research, commercial success, and 6000+ published articles, there remains a lack of understanding of how soluble silicate (Si) species released from SBGs influences cellular responses. Using a systematic approach, this article quantitatively compares the in vitro responses of cells to SBG dissolution products reported in the literature and determines if there is a Si concentration ([Si]) dependent effect on cell behaviour. Cell behavioural responses to SBGs [Si] in dissolution products included metabolic activity (reported in 52 % of articles), cell number (24 %), protein production (22 %), gene expression (22 %) and biomineralization (24 %). There was a difference in the [Si] reported to cause increased (desirable) cellular responses (median = 30.2 ppm) compared to the [Si] reported to cause decreased (undesirable) cellular responses (median = 52.0 ppm) (P ≤ 0.001). The frequency of undesirable outcomes increased with increasing [Si], with ∼3 times more negative outcomes reported above 52 ppm. We also investigated the effect of [Si] on specific cellular outcomes (e.g., metabolic activity, angiogenesis, osteogenesis), if cell type/species influenced these responses and the impact of other ions (Ca, P, Na) within the SBG dissolution media on cell behaviour. This review has, for the first time, quantitatively compared the cellular responses to SBGs from the literature, providing a quantitative overview of SBG in vitro practices and presents evidence of a range of [Si] where desirable cellular responses may be more likely (30-52 ppm). This review also demonstrates the need for greater standardisation of in vitro methodological approaches and recommends some minimum reporting standards. STATEMENT OF SIGNIFICANCE: This systematic review investigates the relationship between the concentration of Si released from Si-bioactive glasses (SBG) and in vitro cell
AU  - Turner,J
AU  - Nandakumar,A
AU  - Anilbhai,N
AU  - Boccaccini,AR
AU  - Jones,JR
AU  - Jell,G
DO  - 10.1016/j.actbio.2023.09.012
EP  - 52
PY  - 2023///
SP  - 39
TI  - The effect of Si species released from bioactive glasses on cell behaviour: A quantitative review.
T2  - Acta Biomater
UR  - http://dx.doi.org/10.1016/j.actbio.2023.09.012
UR  - https://www.ncbi.nlm.nih.gov/pubmed/37714247
VL  - 170
ER  -
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