Imperial College London
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Dr Joseph van Batenburg-Sherwood

Faculty of Engineering, Department of Bioengineering

Lecturer
 
 
 
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Contact

 

+44 (0)20 7594 7244jvbsherwood Website

 
 
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Location

 

Uren 416ASir Michael Uren HubWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Feola:2020:10.1167/iovs.61.5.16,
author = {Feola, AJ and Sherwood, JM and Pardue, MT and Overby, DR and Ethier, CR},
doi = {10.1167/iovs.61.5.16},
journal = {Investigative Ophthalmology and Visual Science},
pages = {1--7},
title = {Age and menopause effects on ocular compliance and aqueous outflow.},
url = {http://dx.doi.org/10.1167/iovs.61.5.16},
volume = {61},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Purpose: Glaucoma is the second leading cause of blindness worldwide. Recent work suggests that estrogen and the timing of menopause play a role in modulating the risk of developing glaucoma. Menopause is known to cause modest changes in intraocular pressure; yet, whether this change is mediated through the outflow pathway remains unknown. Menopause also affects tissue biomechanical properties throughout the body; however, the impact of menopause on ocular biomechanical properties is not well characterized. Methods: Here, we simultaneously assessed the impact of menopause on aqueous outflow facility and ocular compliance, as a measure of corneoscleral shell biomechanics. We used young (3-4 months old) and middle-aged (9-10 months old) Brown Norway rats. Menopause was induced by ovariectomy (OVX), and control animals underwent sham surgery, resulting in the following groups: young sham (n = 5), young OVX (n = 6), middle-aged sham (n = 5), and middle-aged OVX (n = 5). Eight weeks postoperatively, we measured outflow facility and ocular compliance. Results: Menopause resulted in a 34% decrease in outflow facility and a 19% increase in ocular compliance (P = 0.011) in OVX animals compared with sham controls (P = 0.019). Conclusions: These observations reveal that menopause affects several key physiological factors known to be associated with glaucoma, suggesting that menopause may contribute to an increased risk of glaucoma in women.
AU  - Feola,AJ
AU  - Sherwood,JM
AU  - Pardue,MT
AU  - Overby,DR
AU  - Ethier,CR
DO  - 10.1167/iovs.61.5.16
EP  - 7
PY  - 2020///
SN  - 0146-0404
SP  - 1
TI  - Age and menopause effects on ocular compliance and aqueous outflow.
T2  - Investigative Ophthalmology and Visual Science
UR  - http://dx.doi.org/10.1167/iovs.61.5.16
UR  - https://www.ncbi.nlm.nih.gov/pubmed/32407519
UR  - https://iovs.arvojournals.org/article.aspx?articleid=2766110
UR  - http://hdl.handle.net/10044/1/80111
VL  - 61
ER  -
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