My research focuses on the role of the hypothalamus in the control of energy homeostasis and reproduction. Both of these physiological roles have important implications for human health. I am particularly interested in how the gut senses nutritional status and signals to appetite centres of the brain such as the hypothalamus and brain stem to regulate food intake. I am also interested in how central hypothalamic neuropeptide circuits act to control body weight and reproductive function.
I have won funding from sources including the BBSRC, the MRC, the Technology Strategy Board, the Society for Endocrinology, the British Society for Neuroendocrinology, the British Pharmacological Society and the NC3Rs. I have successfully supervised more than twenty PhD students to completion. I am Director of Postgraduate Studies (Research) for the Department of Medicine, and Admissions Tutor for the Faculty of Medicine with particular responsibility for widening participation.
Hockenhull J, Murphy KG, Paterson S, 2017, An observed rise in gamma-hydroxybutyrate-associated deaths in London: Evidence to suggest a possible link with concomitant rise in chemsex, Forensic Science International, Vol:270, ISSN:0379-0738, Pages:93-97
et al., 2016, L-arginine promotes gut hormone release and reduces food intake in rodents, Diabetes Obesity & Metabolism, Vol:18, ISSN:1462-8902, Pages:508-518
et al., 2016, Resection of the Large Bowel Suppresses Hunger and Food Intake and Modulates Gastrointestinal Fermentation, Obesity, Vol:24, ISSN:1930-7381, Pages:1723-1730
Hockenhull J, Murphy KG, Paterson S, 2016, Mephedrone use is increasing in London, Lancet, Vol:387, ISSN:0140-6736, Pages:1719-1720
et al., 2016, Randomised clinical study: inulin short-chain fatty acid esters for targeted delivery of short-chain fatty acids to the human colon, Alimentary Pharmacology & Therapeutics, Vol:44, ISSN:0269-2813, Pages:662-672