My research focuses on the role of the hypothalamus in the control of energy homeostasis and reproduction. Both of these physiological roles have important implications for human health. I am particularly interested in how the gut senses nutritional status and signals to appetite centres of the brain such as the hypothalamus and brain stem to regulate food intake. I am also interested in how central hypothalamic neuropeptide circuits act to control body weight and reproductive function.
I have won funding from sources including the BBSRC, the MRC, the Technology Strategy Board, the Society for Endocrinology, the British Society for Neuroendocrinology, the British Pharmacological Society and the NC3Rs. I have successfully supervised more than twenty PhD students to completion. I am Director of Postgraduate Studies (Research) for the Department of Medicine, and Admissions Tutor for the Faculty of Medicine with particular responsibility for widening participation.
et al., 2018, Mechanistic insights into the more potent effect of KP-54 compared to KP-10 in vivo (vol 12, e0176821, 2017), Plos One, Vol:13, ISSN:1932-6203
et al., 2018, Constant hepatic ATP concentrations during prolonged fasting and absence of effects of Cerbomed Nemos (R) on parasympathetic tone and hepatic energy metabolism, Molecular Metabolism, Vol:7, ISSN:2212-8778, Pages:71-79
McGrath T, Murphy KG, Jones NS, 2018, Quantitative approaches to energy and glucose homeostasis: machine learning and modelling for precision understanding and prediction, Journal of the Royal Society Interface, Vol:15, ISSN:1742-5689
et al., 2017, Impact of ghrelin on body composition and muscle function in a long-term rodent model of critical illness, Plos One, Vol:12, ISSN:1932-6203
et al., 2017, Mechanistic insights into the more potent effect of KP-54 compared to KP-10 in vivo, Plos One, Vol:12, ISSN:1932-6203