My research focuses on the role of the hypothalamus in the control of energy homeostasis and reproduction. Both of these physiological roles have important implications for human health. I am particularly interested in how the gut senses nutritional status and signals to appetite centres of the brain such as the hypothalamus and brain stem to regulate food intake. I am also interested in how central hypothalamic neuropeptide circuits act to control body weight and reproductive function.
I have won funding from sources including the BBSRC, the MRC, the Technology Strategy Board, the Society for Endocrinology, the British Society for Neuroendocrinology, the British Pharmacological Society and the NC3Rs. I have successfully supervised more than twenty PhD students to completion. I am Director of Postgraduate Studies (Research) for the Department of Medicine, and Admissions Tutor for the Faculty of Medicine with particular responsibility for widening participation.
et al., 2017, l-phenylalanine modulates gut hormone release and glucose tolerance, and suppresses food intake through the calcium-sensing receptor in rodents., Int J Obes (lond)
et al., 2017, Impact of ghrelin on body composition and muscle function in a long-term rodent model of critical illness, Plos One, Vol:12, ISSN:1932-6203
Hockenhull J, Murphy KG, Paterson S, 2017, An observed rise in gamma-hydroxybutyrate-associated deaths in London: Evidence to suggest a possible link with concomitant rise in chemsex, Forensic Science International, Vol:270, ISSN:0379-0738, Pages:93-97
Norton M, Murphy KG, 2017, Targeting gastrointestinal nutrient sensing mechanisms to treat obesity., Curr Opin Pharmacol, Vol:37, Pages:16-23
et al., 2017, Mechanistic insights into the more potent effect of KP-54 compared to KP-10 in vivo, Plos One, Vol:12, ISSN:1932-6203