Imperial College London


Faculty of MedicineDepartment of Medicine

Professor of Endocrinology & Metabolism



+44 (0)20 3313 2820k.g.murphy




6N3bCommonwealth BuildingHammersmith Campus





My research focuses on the role of the hypothalamus in the control of energy homeostasis and reproduction. Both of these physiological roles have important implications for human health. I am particularly interested in how the gut senses nutritional status and signals to appetite centres of the brain such as the hypothalamus and brain stem to regulate food intake. I am also interested in how central hypothalamic neuropeptide circuits act to control body weight and reproductive function.

I have won funding from sources including the BBSRC, the MRC, the Technology Strategy Board, the Society for Endocrinology, the British Society for Neuroendocrinology, the British Pharmacological Society and the NC3Rs. I have successfully supervised more than twenty PhD students to completion. I am Director of Postgraduate Studies (Research) for the Department of Medicine, and Admissions Tutor for the Faculty of Medicine with particular responsibility for widening participation.



Murphy KG, Spreckley E, Norton M, et al., L-phenylalanine modulates gut hormone release and glucose tolerance, and suppresses food intake through the calcium sensing receptor in rodents, International Journal of Obesity, ISSN:1476-5497

Hockenhull J, Murphy KG, Paterson S, 2017, An observed rise in gamma-hydroxybutyrate-associated deaths in London: Evidence to suggest a possible link with concomitant rise in chemsex, Forensic Science International, Vol:270, ISSN:0379-0738, Pages:93-97

de Tassigny XD, Jayasena C, Murphy KG, et al., 2017, Mechanistic insights into the more potent effect of KP-54 compared to KP-10 in vivo, Plos One, Vol:12, ISSN:1932-6203

Alamshah A, McGavigan AK, Spreckley E, et al., 2016, L-arginine promotes gut hormone release and reduces food intake in rodents, Diabetes Obesity & Metabolism, Vol:18, ISSN:1462-8902, Pages:508-518

Hettiarachchi P, Wickremasinghe AR, Frost GS, et al., 2016, Resection of the Large Bowel Suppresses Hunger and Food Intake and Modulates Gastrointestinal Fermentation, Obesity, Vol:24, ISSN:1930-7381, Pages:1723-1730

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