My research focuses on the role of the hypothalamus in the control of energy homeostasis and reproduction. Both of these physiological roles have important implications for human health. I am particularly interested in how the gut senses nutritional status and signals to appetite centres of the brain such as the hypothalamus and brain stem to regulate food intake. I am also interested in how central hypothalamic neuropeptide circuits act to control body weight and reproductive function.
I have won funding from sources including the BBSRC, the MRC, the Technology Strategy Board, the Society for Endocrinology, the British Society for Neuroendocrinology, the British Pharmacological Society and the NC3Rs. I have successfully supervised more than twenty PhD students to completion. I am Director of Postgraduate Studies (Research) for the Department of Medicine, and Admissions Tutor for the Faculty of Medicine with particular responsibility for widening participation.
et al., 2017, Impact of ghrelin on body composition and muscle function in a long-term rodent model of critical illness, Plos One, Vol:12, ISSN:1932-6203
Norton M, Murphy KG, 2017, Targeting gastrointestinal nutrient sensing mechanisms to treat obesity., Curr Opin Pharmacol, Vol:37, Pages:16-23
et al., 2017, Mechanistic insights into the more potent effect of KP-54 compared to KP-10 in vivo, Plos One, Vol:12, ISSN:1932-6203
et al., 2017, Misuse of gabapentin and pregabalin may be underestimated., Bmj, Vol:359
et al., 2017, L-phenylalanine modulates gut hormone release and glucose tolerance, and suppresses food intake through the calcium-sensing receptor in rodents, International Journal of Obesity, Vol:41, ISSN:0307-0565, Pages:1693-1701