My research focuses on the role of the hypothalamus in the control of energy homeostasis and reproduction. Both of these physiological roles have important implications for human health. I am particularly interested in how the gut senses nutritional status and signals to appetite centres of the brain such as the hypothalamus and brain stem to regulate food intake. I am also interested in how central hypothalamic neuropeptide circuits act to control body weight and reproductive function.
I have won funding from sources including the BBSRC, the MRC, the Technology Strategy Board, the Society for Endocrinology, the British Society for Neuroendocrinology, the British Pharmacological Society and the NC3Rs. I have successfully supervised more than twenty PhD students to completion. I am Director of Postgraduate Studies (Research) for the Department of Medicine, and Admissions Tutor for the Faculty of Medicine with particular responsibility for widening participation.
et al., L-Arginine increases post-prandial circulating GLP-1 and PYY levels in humans, Obesity, ISSN:1930-7381
et al., 2018, Mechanistic insights into the more potent effect of KP-54 compared to KP-10 in vivo (vol 12, e0176821, 2017), Plos One, Vol:13, ISSN:1932-6203
et al., 2018, Constant hepatic ATP concentrations during prolonged fasting and absence of effects of Cerbomed Nemos (R) on parasympathetic tone and hepatic energy metabolism, Molecular Metabolism, Vol:7, ISSN:2212-8778, Pages:71-79
McGrath T, Murphy KG, Jones NS, 2018, Quantitative approaches to energy and glucose homeostasis: machine learning and modelling for precision understanding and prediction, Journal of the Royal Society Interface, Vol:15, ISSN:1742-5689
et al., 2017, Impact of ghrelin on body composition and muscle function in a long-term rodent model of critical illness, Plos One, Vol:12, ISSN:1932-6203