Imperial College London
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Dr Katy Gaythorpe

Faculty of Medicine, School of Public Health

Lecturer in Epidemiology of Vaccine-Preventable Diseases
 
 
 
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Contact

 

k.gaythorpe

 
 
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Location

 

School of Public HealthWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Sbarra:2023:10.3390/vaccines11081389,
author = {Sbarra, AN and Jit, M and Mosser, JF and Ferrari, M and Cutts, F and Papania, M and Kretsinger, K and McCarthy, KA and Thakkar, N and Gaythorpe, KAM and Gamage, D and Krause, LK and Dansereau, E and Crowcroft, N and Portnoy, A},
doi = {10.3390/vaccines11081389},
journal = {Vaccines (Basel)},
title = {Population-Level Risk Factors Related to Measles Case Fatality: A Conceptual Framework Based on Expert Consultation and Literature Review.},
url = {http://dx.doi.org/10.3390/vaccines11081389},
volume = {11},
year = {2023}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - A better understanding of population-level factors related to measles case fatality is needed to estimate measles mortality burden and impact of interventions such as vaccination. This study aimed to develop a conceptual framework of mechanisms associated with measles case fatality ratios (CFRs) and assess the scope of evidence available for related indicators. Using expert consultation, we developed a conceptual framework of mechanisms associated with measles CFR and identified population-level indicators potentially associated with each mechanism. We conducted a literature review by searching PubMed on 31 October 2021 to determine the scope of evidence for the expert-identified indicators. Studies were included if they contained evidence of an association between an indicator and CFR and were excluded if they were from non-human studies or reported non-original data. Included studies were assessed for study quality. Expert consultation identified five mechanisms in a conceptual framework of factors related to measles CFR. We identified 3772 studies for review and found 49 studies showing at least one significant association with CFR for 15 indicators (average household size, educational attainment, first- and second-dose coverage of measles-containing vaccine, human immunodeficiency virus prevalence, level of health care available, stunting prevalence, surrounding conflict, travel time to major city or settlement, travel time to nearest health care facility, under-five mortality rate, underweight prevalence, vitamin A deficiency prevalence, vitamin A treatment, and general malnutrition) and only non-significant associations for five indicators (antibiotic use for measles-related pneumonia, malaria prevalence, percent living in urban settings, pneumococcal conjugate vaccination coverage, vitamin A supplementation). Our study used expert consultation and a literature review to provide additional insights and a summary of the available evidence of these underlying me
AU  - Sbarra,AN
AU  - Jit,M
AU  - Mosser,JF
AU  - Ferrari,M
AU  - Cutts,F
AU  - Papania,M
AU  - Kretsinger,K
AU  - McCarthy,KA
AU  - Thakkar,N
AU  - Gaythorpe,KAM
AU  - Gamage,D
AU  - Krause,LK
AU  - Dansereau,E
AU  - Crowcroft,N
AU  - Portnoy,A
DO  - 10.3390/vaccines11081389
PY  - 2023///
SN  - 2076-393X
TI  - Population-Level Risk Factors Related to Measles Case Fatality: A Conceptual Framework Based on Expert Consultation and Literature Review.
T2  - Vaccines (Basel)
UR  - http://dx.doi.org/10.3390/vaccines11081389
UR  - https://www.ncbi.nlm.nih.gov/pubmed/37631957
VL  - 11
ER  -
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