Our research interests are in mechanisms employed by nematode parasites to modulate host immune responses. We recently discovered a panel of enzymes secreted by these pathogens which metabolise extracellular nucleotides, important triggers of innate immunity. Current projects are aimed at dissecting the role of these enzymes in regulation of purinergic signalling and mucosal inflammation.
et al., 2021, Acetylcholine production by group 2 innate lymphoid cells promotes mucosal immunity to helminths, Science Immunology, Vol:6, ISSN:2470-9468
et al., 2021, Characterisation of the secreted apyrase family of Heligmosomoides polygyrus, International Journal for Parasitology, Vol:51, ISSN:0020-7519, Pages:39-48
et al., 2018, Special issue: molecular and cellular biology of helminth parasites XI Preface, International Journal for Parasitology, Vol:48, ISSN:0020-7519, Pages:319-320
et al., 2016, Modulation of the immune response by nematode secreted acetylcholinesterase revealed by heterologous expression in Trypanosoma musculi, Plos Pathogens, Vol:12, ISSN:1553-7366, Pages:1-18
et al., 2014, In vivo time-lapse imaging shows diverse niche engagement by quiescent and naturally activated hematopoietic stem cells, Blood, Vol:124, ISSN:0006-4971, Pages:79-83