Imperial College London

DrKleonikiGounaris

Faculty of Natural SciencesDepartment of Life Sciences

Senior Lecturer, Director of Postgraduate Studies
 
 
 
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Contact

 

+44 (0)20 7594 5209k.gounaris

 
 
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Location

 

205Sir Ernst Chain BuildingSouth Kensington Campus

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Summary

 

Summary

Research Interests

Our research interests are in mechanisms employed by nematode parasites to modulate host immune responses. We recently discovered a panel of enzymes secreted by these pathogens which metabolise extracellular nucleotides, important triggers of innate immunity. Current projects are aimed at dissecting the role of these enzymes in regulation of purinergic signalling and mucosal inflammation.

Publications

Journals

Vaux R, Schnoeller C, Berkachy R, et al., 2016, Modulation of the Immune Response by Nematode Secreted Acetylcholinesterase Revealed by Heterologous Expression in Trypanosoma musculi, Plos Pathogens, Vol:12, ISSN:1553-7366

Rashidi NM, Scott MK, Scherf N, et al., 2014, In vivo time-lapse imaging shows diverse niche engagement by quiescent and naturally activated hematopoietic stem cells, Blood, Vol:124, ISSN:0006-4971, Pages:79-83

Afferson HC, Eleftheriou E, Selkirk ME, et al., 2012, Trichinella spiralis Secreted Enzymes Regulate Nucleotide-Induced Mast Cell Activation and Release of Mouse Mast Cell Protease 1, Infection and Immunity, Vol:80, ISSN:0019-9567, Pages:3761-3767

White RR, Miyata S, Papa E, et al., 2011, Characterisation of the Trichinella spiralis Deubiquitinating Enzyme, TsUCH37, an Evolutionarily Conserved Proteasome Interaction Partner, Plos Neglected Tropical Diseases, Vol:5, ISSN:1935-2727

Huang SC-C, Chan DTY, Smyth DJ, et al., 2010, Activation of Nippostrongylus brasiliensis infective larvae is regulated by a pathway distinct from the hookworm Ancylostoma caninum, International Journal for Parasitology, Vol:40, ISSN:0020-7519, Pages:1619-1628

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