Imperial College London

DrKleonikiGounaris

Faculty of Natural SciencesDepartment of Life Sciences

Senior Lecturer, Director of Postgraduate Studies
 
 
 
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Contact

 

+44 (0)20 7594 5209k.gounaris

 
 
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Location

 

205Sir Ernst Chain BuildingSouth Kensington Campus

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Summary

 

Summary

Research Interests

Our research interests are in mechanisms employed by nematode parasites to modulate host immune responses. We recently discovered a panel of enzymes secreted by these pathogens which metabolise extracellular nucleotides, important triggers of innate immunity. Current projects are aimed at dissecting the role of these enzymes in regulation of purinergic signalling and mucosal inflammation.

Publications

Journals

Roberts LB, Schnoeller C, Berkachy R, et al., 2021, Acetylcholine production by group 2 innate lymphoid cells promotes mucosal immunity to helminths, Science Immunology, Vol:6, ISSN:2470-9468

Berkachy R, Smyth DJ, Schnoeller C, et al., 2021, Characterisation of the secreted apyrase family of Heligmosomoides polygyrus, International Journal for Parasitology, Vol:51, ISSN:0020-7519, Pages:39-48

Selkirk ME, Davis RE, Gounaris K, et al., 2018, Special issue: molecular and cellular biology of helminth parasites XI Preface, International Journal for Parasitology, Vol:48, ISSN:0020-7519, Pages:319-320

Vaux R, Schnoeller C, Berkachy R, et al., 2016, Modulation of the immune response by nematode secreted acetylcholinesterase revealed by heterologous expression in Trypanosoma musculi, Plos Pathogens, Vol:12, ISSN:1553-7366, Pages:1-18

Rashidi NM, Scott MK, Scherf N, et al., 2014, In vivo time-lapse imaging shows diverse niche engagement by quiescent and naturally activated hematopoietic stem cells, Blood, Vol:124, ISSN:0006-4971, Pages:79-83

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