Imperial College London


Faculty of Natural SciencesDepartment of Life Sciences

Senior Lecturer, Director of Postgraduate Studies



+44 (0)20 7594 5209k.gounaris




205Sir Ernst Chain BuildingSouth Kensington Campus





Research Interests

Our research interests are in mechanisms employed by nematode parasites to modulate host immune responses. We recently discovered a panel of enzymes secreted by these pathogens which metabolise extracellular nucleotides, important triggers of innate immunity. Current projects are aimed at dissecting the role of these enzymes in regulation of purinergic signalling and mucosal inflammation.



Vaux R, Schnoeller C, Berkachy R, et al., 2016, Modulation of the Immune Response by Nematode Secreted Acetylcholinesterase Revealed by Heterologous Expression in Trypanosoma musculi, Plos Pathogens, Vol:12, ISSN:1553-7366

Rashidi NM, Scott MK, Scherf N, et al., 2014, In vivo time-lapse imaging shows diverse niche engagement by quiescent and naturally activated hematopoietic stem cells, Blood, Vol:124, ISSN:0006-4971, Pages:79-83

Afferson HC, Eleftheriou E, Selkirk ME, et al., 2012, Trichinella spiralis Secreted Enzymes Regulate Nucleotide-Induced Mast Cell Activation and Release of Mouse Mast Cell Protease 1, Infection and Immunity, Vol:80, ISSN:0019-9567, Pages:3761-3767

White RR, Miyata S, Papa E, et al., 2011, Characterisation of the Trichinella spiralis Deubiquitinating Enzyme, TsUCH37, an Evolutionarily Conserved Proteasome Interaction Partner, Plos Neglected Tropical Diseases, Vol:5, ISSN:1935-2727

Rees-Roberts D, Mullen LM, Gounaris K, et al., 2010, Inactivation of the complement anaphylatoxin C5a by secreted products of parasitic nematodes, International Journal for Parasitology, Vol:40, ISSN:0020-7519, Pages:527-532

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