Summary
Research Interests
Our research interests are in mechanisms employed by nematode parasites to modulate host immune responses. We recently discovered a panel of enzymes secreted by these pathogens which metabolise extracellular nucleotides, important triggers of innate immunity. Current projects are aimed at dissecting the role of these enzymes in regulation of purinergic signalling and mucosal inflammation.
Publications
Journals
Roberts L, Berkachy R, Wane M, et al., 2022, Differential regulation of allergic airway inflammation by acetylcholine, Frontiers in Immunology, Vol:13, ISSN:1664-3224
Roberts LB, Schnoeller C, Berkachy R, et al., 2021, Acetylcholine production by group 2 innate lymphoid cells promotes mucosal immunity to helminths, Science Immunology, Vol:6, ISSN:2470-9468
Berkachy R, Smyth DJ, Schnoeller C, et al., 2021, Characterisation of the secreted apyrase family of Heligmosomoides polygyrus, International Journal for Parasitology, Vol:51, ISSN:0020-7519, Pages:39-48
Selkirk ME, Davis RE, Gounaris K, et al., 2018, Special issue: molecular and cellular biology of helminth parasites XI Preface, International Journal for Parasitology, Vol:48, ISSN:0020-7519, Pages:319-320
Vaux R, Schnoeller C, Berkachy R, et al., 2016, Modulation of the immune response by nematode secreted acetylcholinesterase revealed by heterologous expression in Trypanosoma musculi, Plos Pathogens, Vol:12, ISSN:1553-7366, Pages:1-18