Our research interests are in mechanisms employed by nematode parasites to modulate host immune responses. We recently discovered a panel of enzymes secreted by these pathogens which metabolise extracellular nucleotides, important triggers of innate immunity. Current projects are aimed at dissecting the role of these enzymes in regulation of purinergic signalling and mucosal inflammation.
et al., 2016, Modulation of the Immune Response by Nematode Secreted Acetylcholinesterase Revealed by Heterologous Expression in Trypanosoma musculi, Plos Pathogens, Vol:12, ISSN:1553-7366
et al., 2014, In vivo time-lapse imaging shows diverse niche engagement by quiescent and naturally activated hematopoietic stem cells, Blood, Vol:124, ISSN:0006-4971, Pages:79-83
et al., 2012, Trichinella spiralis Secreted Enzymes Regulate Nucleotide-Induced Mast Cell Activation and Release of Mouse Mast Cell Protease 1, Infection and Immunity, Vol:80, ISSN:0019-9567, Pages:3761-3767
et al., 2011, Characterisation of the Trichinella spiralis Deubiquitinating Enzyme, TsUCH37, an Evolutionarily Conserved Proteasome Interaction Partner, Plos Neglected Tropical Diseases, Vol:5, ISSN:1935-2727
et al., 2010, Inactivation of the complement anaphylatoxin C5a by secreted products of parasitic nematodes, International Journal for Parasitology, Vol:40, ISSN:0020-7519, Pages:527-532