Publications
258 results found
Kiguli S, Akech SO, Mtove G, et al., 2014, WHO guidelines on fluid resuscitation in children: missing the FEAST data, BMJ-BRITISH MEDICAL JOURNAL, Vol: 348, ISSN: 0959-535X
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- Citations: 14
Dunning JW, Merson L, Rohde GGU, et al., 2014, Open source clinical science for emerging infections, The Lancet Infectious Diseases, Vol: 14, Pages: 8-9, ISSN: 1473-3099
Obonyo K, 2014, Fluid management of shock in severe malnutrition: what is the evidence for current guidelines and what lessons have been learned from clinical studies and trials in other pediatric populations?, Food and nutrition bulletin, Vol: 35, Pages: S71-78
Church K, 2014, Invasive bacterial co-infection in African children with Plasmodium falciparum malaria: A systematic review, BMC Medicine, Vol: 12
Molyneux S, Njue M, Boga M, et al., 2013, '<i>The Words Will Pass with the Blowing Wind</i>': Staff and Parent Views of the Deferred Consent Process, with Prior Assent, Used in an Emergency Fluids Trial in Two African Hospitals, PLOS ONE, Vol: 8, ISSN: 1932-6203
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- Citations: 42
Olupot-Olupot K, 2013, Management of severe malaria: Results from recent trials, Advances in Experimental Medicine and Biology, Vol: 764, Pages: 241-250
Olupot-Olupot K, 2013, Endotoxaemia is common in children with Plasmodium falciparum malaria, BMC Infectious Diseases, Vol: 13
Olupot-Olupot P, Maitland K, 2013, Management of Severe Malaria: Results from Recent Trials, Advances in Experimental Medicine and Biology, Publisher: Springer New York, Pages: 241-250, ISBN: 9781461447252
Maitland DM, 2013, Exploring mechanisms of excess mortality with early fluid resuscitation: Insights from the FEAST trial, BMC Medicine, Vol: 11
Hendriksen AM, 2012, Diagnosing Severe Falciparum Malaria in Parasitaemic African Children: A Prospective Evaluation of Plasma PfHRP2 Measurement, PLOS Medicine, Vol: 9, ISSN: 1549-1277
Background: In African children, distinguishing severe falciparum malaria from other severe febrile illnesses with coincidentalPlasmodium falciparum parasitaemia is a major challenge. P. falciparum histidine-rich protein 2 (PfHRP2) is released by maturesequestered parasites and can be used to estimate the total parasite burden. We investigated the prognostic significance ofplasma PfHRP2 and used it to estimate the malaria-attributable fraction in African children diagnosed with severe malaria.Methods and Findings: Admission plasma PfHRP2 was measured prospectively in African children (from Mozambique, TheGambia, Kenya, Tanzania, Uganda, Rwanda, and the Democratic Republic of the Congo) aged 1 month to 15 years withsevere febrile illness and a positive P. falciparum lactate dehydrogenase (pLDH)-based rapid test in a clinical trial comparingparenteral artesunate versus quinine (the AQUAMAT trial, ISRCTN 50258054). In 3,826 severely ill children, Plasmadiumfalciparum PfHRP2 was higher in patients with coma (p = 0.0209), acidosis (p,0.0001), and severe anaemia (p,0.0001).Admission geometric mean (95%CI) plasma PfHRP2 was 1,611 (1,350–1,922) ng/mL in fatal cases (n = 381) versus 1,046 (991–1,104) ng/mL in survivors (n = 3,445, p,0.0001), without differences in parasitaemia as assessed by microscopy. There was aU-shaped association between log10 plasma PfHRP2 and risk of death. Mortality increased 20% per log10 increase in PfHRP2above 174 ng/mL (adjusted odds ratio [AOR] 1.21, 95%CI 1.05–1.39, p = 0.009). A mechanistic model assuming a PfHRP2-independent risk of death in non-malaria illness closely fitted the observed data and showed malaria-attributable mortalityless than 50% with plasma PfHRP2#174 ng/mL. The odds ratio (OR) for death in artesunate versus quinine-treated patientswas 0.61 (95%CI 0.44–0.83, p = 0.0018) in the highest PfHRP2 tertile, whereas there was no difference in the lowest tertile(OR 1.05; 95%CI 0.69–1.61; p = 0.82). A li
Ramutton T, Hendriksen ICE, Mwanga-Amumpaire J, et al., 2012, Sequence variation does not confound the measurement of plasma PfHRP2 concentration in African children presenting with severe malaria, MALARIA JOURNAL, Vol: 11
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- Citations: 32
von Seidlein L, Olaosebikan R, Hendriksen ICE, et al., 2012, Predicting the clinical outcome of severe falciparum malaria in african children: findings from a large randomized trial., Clin Infect Dis, Vol: 54, Pages: 1080-1090
BACKGROUND: Data from the largest randomized, controlled trial for the treatment of children hospitalized with severe malaria were used to identify such predictors of a poor outcome from severe malaria. METHODS: African children (<15 years) with severe malaria participated in a randomized comparison of parenteral artesunate and parenteral quinine in 9 African countries. Detailed clinical assessment was performed on admission. Parasite densities were assessed in a reference laboratory. Predictors of death were examined using a multivariate logistic regression model. RESULTS: Twenty indicators of disease severity were assessed, out of which 5 (base deficit, impaired consciousness, convulsions, elevated blood urea, and underlying chronic illness) were associated independently with death. Tachypnea, respiratory distress, deep breathing, shock, prostration, low pH, hyperparasitemia, severe anemia, and jaundice were statistically significant indicators of death in the univariate analysis but not in the multivariate model. Age, glucose levels, axillary temperature, parasite density, heart rate, blood pressure, and blackwater fever were not related to death in univariate models. CONCLUSIONS: Acidosis, cerebral involvement, renal impairment, and chronic illness are key independent predictors for a poor outcome in African children with severe malaria. Mortality is markedly increased in cerebral malaria combined with acidosis. Clinical Trial Registration. ISRCTN50258054.
Maitland K, Babiker A, Kiguli S, et al., 2012, The FEAST trial of fluid bolus in African children with severe infection, LANCET, Vol: 379, Pages: 613-613, ISSN: 0140-6736
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- Citations: 20
Brent K, 2012, Tailoring management of severe and complicated malnutrition: More research is required first, Pathogens and Global Health, Vol: 106, Pages: 197-199
Ala S, 2012, External Financial Aid to Blood Transfusion Services in Sub-Saharan Africa: A Need for Reflection, PLoS Medicine, Vol: 9
Hassall I, 2012, The microbiologic safety of umbilical cord blood transfusion for children with severe anemia in Mombasa, Kenya, Transfusion, Vol: 52, Pages: 1542-1551
Hassall K, 2012, Blood Transfusion in Resource-limited Settings
Talbert K, 2012, Diarrhoea complicating severe acute malnutrition in kenyan children: A prospective descriptive study of risk factors and outcome, PLoS ONE, Vol: 7
Berend K, 2011, Mortality after Fluid Bolus in African Children with Sepsis, NEW ENGLAND JOURNAL OF MEDICINE, Vol: 365, Pages: 1349-1349, ISSN: 0028-4793
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- Citations: 3
Ford SR, Visram A, 2011, Mortality after Fluid Bolus in African Children with Sepsis, NEW ENGLAND JOURNAL OF MEDICINE, Vol: 365, Pages: 1348-1348, ISSN: 0028-4793
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- Citations: 10
Maitland K, Akech SO, Russell EC, 2011, Mortality after fluid bolus in African children with sepsis REPLY, New England Journal of Medicine, Vol: 365, Pages: 1351-1353, ISSN: 0028-4793
Kissoon N, Carcillo JA, 2011, Mortality after Fluid Bolus in African Children with Sepsis, NEW ENGLAND JOURNAL OF MEDICINE, Vol: 365, Pages: 1350-1350, ISSN: 0028-4793
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- Citations: 9
Joyner BL, Boyd JM, Kocis KC, 2011, Mortality after Fluid Bolus in African Children with Sepsis, NEW ENGLAND JOURNAL OF MEDICINE, Vol: 365, Pages: 1349-1350, ISSN: 0028-4793
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- Citations: 6
Scott H, Melendez E, Cruz AT, 2011, Mortality after Fluid Bolus in African Children with Sepsis, NEW ENGLAND JOURNAL OF MEDICINE, Vol: 365, Pages: 1350-1351, ISSN: 0028-4793
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- Citations: 7
Ribeiro CT, Delgado AF, de Carvalho WB, 2011, Mortality after Fluid Bolus in African Children with Sepsis, NEW ENGLAND JOURNAL OF MEDICINE, Vol: 365, Pages: 1348-1349, ISSN: 0028-4793
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- Citations: 4
Thuo N, Ungphakorn W, Karisa J, et al., 2011, Dosing regimens of oral ciprofloxacin for children with severe malnutrition: a population pharmacokinetic study with Monte Carlo simulation, JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, Vol: 66, Pages: 2336-2345, ISSN: 0305-7453
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- Citations: 15
Maitland K, Molyneux S, Boga M, et al., 2011, Use of deferred consent for severely ill children in a multi-centre phase III trial, TRIALS, Vol: 12
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- Citations: 56
Abubakar A, Holding P, Mwangome M, et al., 2011, Maternal perceptions of factors contributing to severe under-nutrition among children in a rural African setting, RURAL AND REMOTE HEALTH, Vol: 11, ISSN: 1445-6354
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- Citations: 25
Dondorp AM, Fanello CI, Hendriksen IC, et al., 2011, Erratum: Artesunate versus quinine in the treatment of severe falciparum malaria in African children (AQUAMAT): an open-label, randomised trial (The Lancet (2010) 376(9753) (1647–1657) (S0140673610619241) (10.1016/S0140-6736(10)61924-1)), The Lancet, Vol: 377, ISSN: 0140-6736
Dondorp AM, Fanello CI, Hendriksen ICE, et al, for the AQUAMAT group. Artesunate versus quinine in the treatment of severe falciparum malaria in African children (AQUAMAT): an open-label, randomised trial. Lancet 2010; 376: 1647–57—In this Article (Nov 13), the row in table 2 for death or sequelae at 28 days in the quinine group should have been: 316/2695 (11·7%). In table 1, the data in parentheses for coma depth are IQR. The last line of the legend for figure 3 should have read: “I2 denotes the percentage of total variation across subgroups resulting from heterogeneity rather than chance, with the p value of significance”. The title of figure 5 should have read: “Meta-analysis of all randomised controlled trials that have compared mortality of severe malaria in patients treated with parenteral artesunate versus parenteral quinine12–16”. These corrections have been made to the online version as of Jan 7, 2011.
Mogeni JA, 2011, Diagnostic performance of visible severe wasting for identifying severe acute malnutrition in children admitted to hospital in Kenya, Bulletin of the World Health Organization, Vol: 89, Pages: 900-906
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