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@article{Alhazzani:2020:10.1097/ccm.0000000000004363,
author = {Alhazzani, W and Møller, MH and Arabi, YM and Loeb, M and Gong, MN and Fan, E and Oczkowski, S and Levy, MM and Derde, L and Dzierba, A and Du, B and Aboodi, M and Wunsch, H and Cecconi, M and Koh, Y and Chertow, DS and Maitland, K and Alshamsi, F and Belley-Cote, E and Greco, M and Laundy, M and Morgan, JS and Kesecioglu, J and McGeer, A and Mermel, L and Mammen, MJ and Alexander, PE and Arrington, A and Centofanti, JE and Citerio, G and Baw, B and Memish, ZA and Hammond, N and Hayden, FG and Evans, L and Rhodes, A},
doi = {10.1097/ccm.0000000000004363},
journal = {Critical Care Medicine},
pages = {e440--e469},
title = {Surviving sepsis campaign: guidelines on the management of critically Ill adults with coronavirus disease 2019 (COVID-19)},
url = {http://dx.doi.org/10.1097/ccm.0000000000004363},
volume = {48},
year = {2020}
}

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TY  - JOUR
AB  - Background: The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of a rapidly spreading illness, Coronavirus Disease 2019 (COVID-19), affecting thousands of people around the world. Urgent guidance for clinicians caring for the sickest of these patients is needed.Methods: We formed a panel of 36 experts from 12 countries. All panel members completed the World Health Organization conflict of interest disclosure form. The panel proposed 53 questions that are relevant to the management of COVID-19 in the ICU. We searched the literature for direct and indirect evidence on the management of COVID-19 in critically ill patients in the ICU. We identified relevant and recent systematic reviews on most questions relating to supportive care. We assessed the certainty in the evidence using the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) approach, then generated recommendations based on the balance between benefit and harm, resource and cost implications, equity, and feasibility. Recommendations were either strong or weak, or in the form of best practice recommendations.Results: The Surviving Sepsis Campaign COVID-19 panel issued 54 statements, of which four are best practice statements, nine are strong recommendations, and 35 are weak recommendations. No recommendation was provided for six questions. The topics were: 1) infection control, 2) laboratory diagnosis and specimens, 3) hemodynamic support, 4) ventilatory support, and 5) COVID-19 therapy.Conclusion: The Surviving Sepsis Campaign COVID-19 panel issued several recommendations to help support healthcare workers caring for critically ill ICU patients with COVID-19. When available, we will provide new evidence in further releases of these guidelines.
AU  - Alhazzani,W
AU  - Møller,MH
AU  - Arabi,YM
AU  - Loeb,M
AU  - Gong,MN
AU  - Fan,E
AU  - Oczkowski,S
AU  - Levy,MM
AU  - Derde,L
AU  - Dzierba,A
AU  - Du,B
AU  - Aboodi,M
AU  - Wunsch,H
AU  - Cecconi,M
AU  - Koh,Y
AU  - Chertow,DS
AU  - Maitland,K
AU  - Alshamsi,F
AU  - Belley-Cote,E
AU  - Greco,M
AU  - Laundy,M
AU  - Morgan,JS
AU  - Kesecioglu,J
AU  - McGeer,A
AU  - Mermel,L
AU  - Mammen,MJ
AU  - Alexander,PE
AU  - Arrington,A
AU  - Centofanti,JE
AU  - Citerio,G
AU  - Baw,B
AU  - Memish,ZA
AU  - Hammond,N
AU  - Hayden,FG
AU  - Evans,L
AU  - Rhodes,A
DO  - 10.1097/ccm.0000000000004363
EP  - 469
PY  - 2020///
SN  - 0090-3493
SP  - 440
TI  - Surviving sepsis campaign: guidelines on the management of critically Ill adults with coronavirus disease 2019 (COVID-19)
T2  - Critical Care Medicine
UR  - http://dx.doi.org/10.1097/ccm.0000000000004363
UR  - https://journals.lww.com/ccmjournal/Abstract/9000/Surviving_Sepsis_Campaign__Guidelines_on_the.95707.aspx
UR  - http://hdl.handle.net/10044/1/78657
VL  - 48
ER  -

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