Publications
260 results found
Mansour S, Shakweh E, Tsironis C, et al., 2020, The Perfect Sleeve- How to avoid and manage Sleeve Gastrectomy Leak based on Current Best Evidence, 11th Annual Scientific Meeting of the British-Obesity-and-Metabolic-Surgery-Society (BOMSS), Publisher: SPRINGER, Pages: S47-S47, ISSN: 0960-8923
Mansour S, Shakweh E, Tsironis C, et al., 2020, Standard-steps approach improves safety and efficacy in training bariatric fellowships, 11th Annual Scientific Meeting of the British-Obesity-and-Metabolic-Surgery-Society (BOMSS), Publisher: SPRINGER, Pages: S29-S30, ISSN: 0960-8923
Kamocka A, Miras AD, Perez-Pevida B, et al., 2020, Long versus standard biliopancreatic limb in the Roux-en-Y gastric bypass. The LONG LIMB Trial., 11th Annual Scientific Meeting of the British-Obesity-and-Metabolic-Surgery-Society (BOMSS), Publisher: SPRINGER, Pages: S4-S4, ISSN: 0960-8923
Miras AD, Ravindra S, Humphreys A, et al., 2019, Metabolic changes and diabetes microvascular complications 5 years after obesity surgery., Obesity Surgery, Vol: 29, Pages: 3907-3911, ISSN: 0960-8923
BACKGROUND: Obesity surgery has pronounced effects on metabolic profile of patients with type 2 diabetes mellitus (T2DM); however, reports on long-term remission rates based on the standardised and holistic criteria by the International Diabetes Federation (IDF) and effects on T2DM microvascular complications are scarce in the literature. In this retrospective clinical trial, our objectives were to assess these variables 5 years after surgery. METHODS: Clinical data and direct measurements of renal and retinal damage were collected prospectively and analysed retrospectively for 82 patients with T2DM who underwent obesity surgery and were followed up for 5 years. RESULTS: The cohort of 82 patients with T2DM that were followed up 5 years after obesity surgery was predominantly female (71%) with a median age of 51 years, weight of 133.5 kg, BMI of 46.8 kg/m2 and pre-operative duration of T2DM of 8 years; 6% of patients had diet-controlled T2DM, 57% were on non-insulin treatment and 37% were on insulin treatment pre-operatively. Of the total 82 patients, 59 patients underwent Roux-en-Y gastric bypass, 15 sleeve gastrectomy and 8 patients underwent gastric band operations. At 5 years, 5% and 15% patients achieved optimisation and improvement of the metabolic state based on the IDF criteria respectively. Surgery was associated with almost halving of the albumin-creatinine ratio in 22 patients with pre-existing albuminuria (follow-up data available for 64 patients) and an overall stabilisation of retinopathy in 24 patients with retinal images available at 5 years. CONCLUSION: Whilst the findings on microvascular complications are encouraging, the rates of metabolic remission were lower than expected and raise the need for validated protocols to assist clinicians in managing these patients more aggressively post-operatively to achieve optimum cardio-metabolic risk factor control and hopefully further reduction in microvascular an
Doganay E, Boshier PR, Halliday LJ, et al., 2019, The impact of prehabilitation on parameters of body composition in patients undergoing multimodal therapy for oesophago-gastric (OG) cancer, International Surgical Congress of the Association-of-Surgeons-of-Great-Britain-and-Ireland (ASGBI), Publisher: WILEY, Pages: 36-36, ISSN: 0007-1323
Halley M, Wynter-Blyth V, Halliday L, et al., 2019, PROMPT: The Perioperative RemOte Monitoring of PaTients: Evaluation of the impact of a digital health platform on oesophago-gastric cancer patients taking part in a surgical prehabilitation programme, International Surgical Congress of the Association-of-Surgeons-of-Great-Britain-and-Ireland (ASGBI), Publisher: WILEY, Pages: 39-40, ISSN: 0007-1323
Halliday L, Doganay E, Osborn H, et al., 2019, Pre-operative functional and psychological impact of prehabilitation in patients with oesophago-gastric cancer, International Surgical Congress of the Association-of-Surgeons-of-Great-Britain-and-Ireland (ASGBI), Publisher: WILEY, Pages: 35-35, ISSN: 0007-1323
Halliday L, Doganay E, Lada H, et al., 2019, Prehabilitation in oesophago-gastric cancer: the impact on post-operative outcomes, International Surgical Congress of the Association-of-Surgeons-of-Great-Britain-and-Ireland (ASGBI), Publisher: WILEY, Pages: 79-79, ISSN: 0007-1323
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Kamocka A, Miras AD, Perez-Pevida B, et al., 2019, LONG VS STANDARD BILIOPANCREATIC LIMB ROUX-EN-Y GASTRIC BYPASS FOR TYPE 2 DIABETES. THE LONG LIMB TRIAL Type 2 diabetes and metabolic surgery, 24th World Congress of the International-Federation-for-the-Surgery-of-Obesity-and-Metabolic-Disorders (IFSO) / 21st SECO Congress, Publisher: SPRINGER, Pages: 234-234, ISSN: 0960-8923
Behary P, Tharakan G, Alexiadou K, et al., 2019, Combined GLP-1, oxyntomodulin, and peptide YY improves body weight and glycemia in obesity and prediabetes/type 2 diabetes: a randomized single-blinded placebo controlled study, Diabetes Care, Vol: 42, Pages: 1446-1453, ISSN: 0149-5992
OBJECTIVE: Roux-en-Y gastric bypass (RYGB) augments postprandial secretion of glucagon-like peptide 1 (GLP-1), oxyntomodulin (OXM), and peptide YY (PYY). Subcutaneous infusion of these hormones ("GOP"), mimicking postprandial levels, reduces energy intake. Our objective was to study the effects of GOP on glycemia and body weight when given for 4 weeks to patients with diabetes and obesity. RESEARCH DESIGN AND METHODS: In this single-blinded mechanistic study, obese patients with prediabetes/diabetes were randomized to GOP (n = 15) or saline (n = 11) infusion for 4 weeks. We also studied 21 patients who had undergone RYGB and 22 patients who followed a very low-calorie diet (VLCD) as unblinded comparators. Outcomes measured were 1) body weight, 2) fructosamine levels, 3) glucose and insulin during a mixed meal test (MMT), 4) energy expenditure (EE), 5) energy intake (EI), and 6) mean glucose and measures of glucose variability during continuous glucose monitoring. RESULTS: GOP infusion was well tolerated over the 4-week period. There was a greater weight loss (P = 0.025) with GOP (mean change -4.4 [95% CI -5.3, -3.5] kg) versus saline (-2.5 [-4.1, -0.9] kg). GOP led to a greater improvement (P = 0.0026) in fructosamine (-44.1 [-62.7, -25.5] µmol/L) versus saline (-11.7 [-18.9, -4.5] µmol/L). Despite a smaller weight loss compared with RYGB and VLCD, GOP led to superior glucose tolerance after a mixed-meal stimulus and reduced glycemic variability compared with RYGB and VLCD. CONCLUSIONS: GOP infusion improves glycemia and reduces body weight. It achieves superior glucose tolerance and reduced glucose variability compared with RYGB and VLCD. GOP is a viable alternative for the treatment of diabetes with favorable effects on body weight.
Mourikis TP, Benedetti L, Foxall E, et al., 2019, Patient-specific cancer genes contribute to recurrently perturbed pathways and establish therapeutic vulnerabilities in esophageal adenocarcinoma, Nature Communications, Vol: 10, Pages: 1-17, ISSN: 2041-1723
The identification of cancer-promoting genetic alterations is challenging particularly in highly unstable and heterogeneous cancers, such as esophageal adenocarcinoma (EAC). Here we describe a machine learning algorithm to identify cancer genes in individual patients considering all types of damaging alterations simultaneously. Analysing 261 EACs from the OCCAMS Consortium, we discover helper genes that, alongside well-known drivers, promote cancer. We confirm the robustness of our approach in 107 additional EACs. Unlike recurrent alterations of known drivers, these cancer helper genes are rare or patient-specific. However, they converge towards perturbations of well-known cancer processes. Recurrence of the same process perturbations, rather than individual genes, divides EACs into six clusters differing in their molecular and clinical features. Experimentally mimicking the alterations of predicted helper genes in cancer and pre-cancer cells validates their contribution to disease progression, while reverting their alterations reveals EAC acquired dependencies that can be exploited in therapy.
Hagens ERC, Henegouwen MIVB, van Sandick JW, et al., 2019, Distribution of lymph node metastases in esophageal carcinoma [TIGER study]: study protocol of a multinational observational study, BMC CANCER, Vol: 19, ISSN: 1471-2407
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- Citations: 44
Behary P, Tharakan G, Alexiadou K, et al., 2019, Combined GLP-1, Oxyntomodulin, and Peptide YY Improves Glycaemia and Body Weight in Obesity and Type 2 Diabetes: A Randomized, Single-Blinded Study, 79th Scientific Sessions of the American-Diabetes-Association (ADA), Publisher: AMER DIABETES ASSOC, ISSN: 0012-1797
Stevens S, Thomas R, Peters C, et al., 2019, ENDOLUMINAL VACUUM THERAPY FOR THE MANAGEMENT OF BOERHAAVE SYNDROME, Annual Meeting of the British-Society-of-Gastroenterology (BSG), Publisher: BMJ PUBLISHING GROUP, Pages: A53-A53, ISSN: 0017-5749
Doganay E, Moorthy K, 2019, Prehabilitation for esophagectomy, JOURNAL OF THORACIC DISEASE, Vol: 11, Pages: S632-S638, ISSN: 2072-1439
Frankell AM, Jammula S, Li X, et al., 2019, The landscape of selection in 551 esophageal adenocarcinomas defines genomic biomarkers for the clinic, Nature Genetics, Vol: 51, Pages: 506-516, ISSN: 1061-4036
Esophageal adenocarcinoma (EAC) is a poor-prognosis cancer type with rapidly rising incidence. Understanding of the genetic events driving EAC development is limited, and there are few molecular biomarkers for prognostication or therapeutics. Using a cohort of 551 genomically characterized EACs with matched RNA sequencing data, we discovered 77 EAC driver genes and 21 noncoding driver elements. We identified a mean of 4.4 driver events per tumor, which were derived more commonly from mutations than copy number alterations, and compared the prevelence of these mutations to the exome-wide mutational excess calculated using non-synonymous to synonymous mutation ratios (dN/dS). We observed mutual exclusivity or co-occurrence of events within and between several dysregulated EAC pathways, a result suggestive of strong functional relationships. Indicators of poor prognosis (SMAD4 and GATA4) were verified in independent cohorts with significant predictive value. Over 50% of EACs contained sensitizing events for CDK4 and CDK6 inhibitors, which were highly correlated with clinically relevant sensitivity in a panel of EAC cell lines and organoids.
Kamocka A, Perez-Pevida B, Miras AD, et al., 2019, Total small bowel length varies considerably among patients with obesity and diabetes: Is there a role for individualisation of limb lengths in Roux-en-Y gastric bypass?, 10th Annual Scientific Meeting of the British-Obesity-and-Metabolic-Surgery-Society (BOMSS), Publisher: SPRINGER, Pages: S11-S11, ISSN: 0960-8923
Scott AJ, Mason SE, Langdon AJ, et al., 2018, Prospective risk factor analysis for the development of post-operative Urinary retention following ambulatory general surgery, World Journal of Surgery, Vol: 42, Pages: 3874-3879, ISSN: 1432-2323
AimsPost-operative urinary retention (POUR) is a common cause of unplanned admission following day-case surgery and has negative effects on both patient and surgical institution. We aimed to prospectively evaluate potential risk factors for the development of POUR following day-case general surgical procedures.MethodsOver a 24-week period, consecutive adult patients undergoing elective day-case general surgery at a single institution were prospectively recruited. Data regarding urinary symptoms, comorbidities, drug history, surgery and perioperative anaesthetic drug use were collected. The primary outcome was the incidence of POUR, defined as an impairment of bladder voiding requiring either urethral catheterisation, unplanned overnight admission or both. Potential risk factors for the development of POUR were analysed by logistic regression.ResultsA total of 458 patients met the inclusion criteria during the study period, and data were collected on 382 (83%) patients (74.3% male). Sixteen patients (4.2%) experienced POUR. Unadjusted analysis demonstrated three significant risk factors for the development of POUR: age ≥ 56 years (OR 7.77 [2.18–27.78], p = 0.002), laparoscopic surgery (OR 3.37 [1.03–12.10], p = 0.044) and glycopyrrolate administration (OR 5.56 [2.00–15.46], p = 0.001). Male sex and lower urinary tract symptoms were not significant factors. Multivariate analysis combining type of surgery, age and glycopyrrolate use revealed that only age ≥ 56 years (OR 8.14 [2.18–30.32], p = 0.0018) and glycopyrrolate administration (OR 3.48 [1.08–11.24], p = 0.0370) were independently associated with POUR.ConclusionsPatients aged at least 56 years and/or requiring glycopyrrolate—often administered during laparoscopic procedures—are at increased risk of POUR following ambulatory general surgery.
Kaur V, Moorthy K, Lope MM, et al., 2018, Successful endoscopic closure of Boerhaave Syndrome using the Apollo OverStitch System, 21st Annual Meeting of the Association-of-Upper-Gastrointestinal-Surgeons-of-Great-Britain-and-Ireland (AUGIS), Publisher: WILEY, Pages: 42-42, ISSN: 0007-1323
Kamocka A, McGlone ER, Pevida BP, et al., 2018, SURGICAL REVISION OF CANDY CANE AFTER ROUX-EN-Y GASTRIC BYPASS, 23rd World Congress of the International-Federation-for-the-Surgery-of-Obesity-and-Metabolic-Disorders (IFSO), Publisher: SPRINGER, Pages: 232-232, ISSN: 0960-8923
Tharakan G, Miras A, Chahal H, et al., 2018, BARIATRIC SURGERY OUTCOMES IN THE OVER-60S: A SINGLE CENTRE, OBSERVATIONAL STUDY FROM 2007-2012., 23rd World Congress of the International-Federation-for-the-Surgery-of-Obesity-and-Metabolic-Disorders (IFSO), Publisher: SPRINGER, Pages: 376-376, ISSN: 0960-8923
Markakis HC, Ahmed A, Moorthy K, 2018, MINIMALLY INVASIVE TRANSGASTRIC APPROACH TO REMOVAL OF THE DUODENAL-JEJUNAL BYPASS LINER FOLLOWING FAILED ENDOSCOPIC APPROACH, 23rd World Congress of the International-Federation-for-the-Surgery-of-Obesity-and-Metabolic-Disorders (IFSO), Publisher: SPRINGER, Pages: 169-169, ISSN: 0960-8923
Tan M, Purkayastha S, Moorthy K, et al., 2018, ONE ANASTOMOSIS GASTRIC BYPASS - A VIABLE OPTION FOR REVISION BARIATRIC SURGERY, 23rd World Congress of the International-Federation-for-the-Surgery-of-Obesity-and-Metabolic-Disorders (IFSO), Publisher: SPRINGER, Pages: 370-370, ISSN: 0960-8923
Clark J, Petrou N, Komocha A, et al., 2018, REFRACTORY CHRONIC PAIN POST ROUX-EN Y GASTRIC BYPASS; DEFINING A MANAGEMENT STRATEGY., 23rd World Congress of the International-Federation-for-the-Surgery-of-Obesity-and-Metabolic-Disorders (IFSO), Publisher: SPRINGER, Pages: 207-207, ISSN: 0960-8923
Halliday L, Doganay E, Quan J, et al., 2018, Compliance with enhanced recovery protocols and postoperative complications: what is the link?, International Surgical Congress of the Association-of-Surgeons-of-Great-Britain-and-Ireland, Publisher: WILEY, Pages: 219-219, ISSN: 0007-1323
Doganay E, Halliday L, McCormack O, et al., 2018, Improving compliance with enhanced recovery protocols in Oesophago-Gastric (OG) cancer surgery: a collaborative quality improvement project, International Surgical Congress of the Association-of-Surgeons-of-Great-Britain-and-Ireland, Publisher: WILEY, Pages: 214-214, ISSN: 0007-1323
Doganay E, Halliday L, Shipway D, et al., 2018, Frailty predicts post-operative outcomes in elderly patients undergoing Oesophago-Gastric (OG) cancer surgery, International Surgical Congress of the Association-of-Surgeons-of-Great-Britain-and-Ireland, Publisher: WILEY, Pages: 204-204, ISSN: 0007-1323
Tan M, Purkayastha S, Moorthy K, et al., 2018, Mini-gastric Bypass: A Viable Option for Revision Bariatric Surgery, 9th Annual Scientific Meeting of the British-Obesity-and-Metabolic-Surgery-Society (BOMSS), Publisher: WILEY, Pages: 14-15, ISSN: 0007-1323
Shipway D, Koizia L, Winterkorn N, et al., 2018, Embedded geriatric surgical liaison is associated with reduced inpatient length of stay in older patients admitted for gastrointestinal surgery, Future Healthcare Journal, Vol: 5 (2)
Kamocka A, McGlone ER, Perez-Pevida B, et al., 2018, Surgical revision of candy cane after Roux-en-Y gastric bypass, Obesity Update 2018, Pages: CD2.3-CD2.3, ISSN: 1470-3947
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