My area of expertise in haematopathology. I have been in the field of haematopathology for over 20 years, and I have worked/trained across three continents (Europe, Asia and North America). At the Hammersmith Hospital / Imperial College, I lead diagnostics, translational research and training in haematopathology. My referral practice caters to haematopathologists across the UK, and to many other haematopathologists in Europe, Asia and Africa. I have over 175 publications, majority of which are in the field of haematopathology. I direct the Advanced Haematopathology course at the Hammersmith Hospital, which is a postgraduate course of international repute. I am also the Lead for the Clinical Academic Training programme in Histopathology at the Imperial College, mentoring and training the clinical academics of the future. In haematopathology research, my collaborations extend across the UK, and I also collaborate with investigators and institutions in Europe, United States, Asia and Africa. As the Advisor for Haematopathology at the Royal College of Pathologists, I play a critical role in improving standards of training and practice of haematopathology in the UK. I am a firm believer in global medicine and science and in fostering international collaboration to promote translational research and training in haematopathology and in other branches of medicine.
I lead translation research studies in lymphomas, myeloma and other bone marrow based malignancies. My areas of interest include:
1. Refining lymphoma classification & subtyping for clinical utility and improved biological relevance
- Identification of novel subtypes within marginal zone B-cell lymphoma
- Immunologically defined subsets of follicular lymphoma - clinical implications
- Characterization of BCL2 and BCL6 translocation negative follicular lymphoma
- Molecular subtyping of diffuse large B-cell lymphoma & molecular algorithms for clinical usage
- Diagnostic algorithms for distinction between Burkitt lymphoma, diffuse large B-cell lymphoma and the intermediate category.
2. Biology of immune deficiency associated lymphoid proliferations
- HHV-8 associated lymphoproliferative disease and multicentric Castleman disease
- HHV-8 associated haemophagocytic syndrome
- Posttransplant lymphoproliferative disorders
- Chromosomal translocations, gene methylation, clonality of the B and T-cell populations, & understanding the role immune cells in the microenvironment.
- HIV lymphomas
- Defining lymphoma precursors or in-situ lymphomas
- Prevalence of in-situ lymphomas
4. Understanding lymphomagenesis through epidemiological differences.
- Worked in India for over 15 years and started a national registry for lymphomas.
- Reviewer of lymphoma diagnosis on NCI sponsored studies in Africa
- Collaborator for the Sub-Saharan Africa lymphoma Consortium
5. Identifying prognostic markers in myeloma
6. Bone marrow based haematological malignancies
- Application of a wide array of antibodies (immunohistochemistry) in paraffin sections of bone marrow trephine biopsies
- Refining criteria for diagnosis of malignant haematological diseases on bone marrow trephine biopsies.
et al., 2017, Relapse of HHV8-positive multicentric Castleman disease following rituximab-based therapy in HIV-positive patients, Blood, Vol:129, ISSN:0006-4971, Pages:2143-2147
et al., 2017, Mutational landscape of B-cell post-transplant lymphoproliferative disorders, British Journal of Haematology, Vol:178, ISSN:0007-1048, Pages:48-56
et al., 2017, Diagnostic Utility of Lymphoid Enhancer Binding Factor 1 Immunohistochemistry in Small B-Cell Lymphomas, American Journal of Clinical Pathology, Vol:147, ISSN:0002-9173, Pages:292-300
et al., 2017, Enteropathy-associated T cell lymphoma subtypes are characterized by loss of function of SETD2, Journal of Experimental Medicine, Vol:214, ISSN:0022-1007, Pages:1371-1386
et al., 2016, Optimal Minimal Panels of Immunohistochemistry for Diagnosis of B-Cell Lymphoma for Application in Countries With Limited Resources and for Triaging Cases Before Referral to Specialist Centers, American Journal of Clinical Pathology, Vol:145, ISSN:0002-9173, Pages:687-695