Imperial College London

DrKikkeriNaresh

Faculty of MedicineDepartment of Metabolism, Digestion and Reproduction

Professor of Practice (Pathology)
 
 
 
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Contact

 

+44 (0)20 3313 3969k.naresh

 
 
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Location

 

Office 6, Building 541, G-BlockHammersmith HospitalHammersmith Campus

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Summary

 

Summary

My area of expertise is haematopathology with a focus on lymphomas, bone marrow pathology and molecular pathology. I have been in the field of haematopathology for over 25 years, and I have worked/trained across three continents (Europe, Asia and North America). At the Hammersmith Hospital / Imperial College, I lead diagnostics, translational research and training in haematopathology. My referral practice caters to haematopathologists across the UK, and to many other haematopathologists outside of UK. I am the current Chair of the British Lymphoma Pathology Group (BLPG). Through my activities in BLPG and Royal College of Pathologists, I play a critical role in improving standards of training and practice of haematopathology in the UK. I have over 240 publications, majority of which are in the field of haematopathology. In haematopathology research, my collaborations extend across the UK, and I also collaborate with investigators and institutions in Europe, United States, Asia and Africa. I am a firm believer in global medicine and science and in fostering international collaboration to promote translational research and training in haematopathology and in other branches of medicine.

At Imperial, I have been responsible for building the Specialist Integrated Haematological Malignancy Diagnostic Service (SIHMDS) at Imperial. This is a centralised service for a large number of hospitals in and around London. I have also led the development of a supra-regional / national lymphoma referral service at the Hammersmith Hospital and supports diagnosis of challenging cases from across the country. I also lead on molecular diagnostic services and on genomics at Imperial.

I have been responsible for leading the NIHR’s Clinical Academic Training programme in Histopathology at the Hammersmith Hospital / Imperial since its inception in 2006. Through this, I have been mentoring and training the clinical academics of the future. I have other major commitments in education – clinical training in histopathology & haematology; postgraduate education (PhD, MRes & MSc) and undergraduate education. I support the specialised training of haematopathologists from all over UK and rest of the world. I contribute to education in haematopathology by lecturing in many local, regional, national and international meetings.

 I also lead activities of cellular and molecular pathology in the Imperial Biomedical Research Centre. My primary research interest and those that I drive, pertain to translational research. I also support other investigators undertaking translational and basic research. Most of the research that I drive is focussed on lymphoid malignancies. I also dwell to a lesser extent on plasma cell, myeloid and other haematological malignancies. My translational research interests can be summarised under:

- Genomics of B cell lymphomas
- Genomics of T cell lymphomas
- Biology of Immune deficiency lymphoid proliferations including proliferations in post-transplant and HIV settings.
- Biology of Hodgkin lymphoma
- Role of micro-environment in maintenance and evolution of malignant lymphoid populations
- Biology of oncogenic viruses in lymphomagenesis and patient outcomes
- Early steps and lesions in lymphomagenesis and pathways of evolution
- Developing diagnostic algorithms using immunohistochemistry and other ancillary tools for lymphomas.
- Identification of unique subtypes of lymphomas and lymphoid proliferations leading to refinements in classification of disease
- Establishing new antibodies in the diagnosis of different lymphoma categories.
- Biomarker discovery – for stratifying haematological malignancies
- Correlation of immunohistochemistry and flow cytometry in diagnostic haemato-oncology
- Refining criteria for diagnosis on bone marrow trephine biopsies
- Disease evolution following stem cell transplantation
- Epidemiology and molecular epidemiology of lymphomas
- Myeloma research

 I have been in various leadership positions at all levels – local, regional, national and international.

Publications

Journals

Xu D, Claudiani S, Naresh K, et al., 2019, Blast crisis of chronic myeloid leukemia with plasmacytoid dendritic cell phenotype associated with a rare fusion transcript, e13a3 BCR-ABL1., Leuk Lymphoma, Pages:1-2

Granai M, Ambrosio MR, Akarca A, et al., 2019, Role of Epstein-Barr virus in transformation of follicular lymphoma to diffuse large B-cell lymphoma: a case report and review of the literature, Haematologica, Vol:104, ISSN:0390-6078, Pages:E269-E273

Hanley BP, Nesr G, Yebra-Fernandez E, et al., 2019, T-cell Prolymphocytic Leukaemia in a Patient with Chronic Myeloid Leukaemia Receiving Nilotinib: First Documented Report, Journal of Pathology, Vol:248, ISSN:0022-3417, Pages:S12-S12

Lo Bello G, Naresh KN, 2019, HTLV-1 status should be recorded in cases of T cell lymphomas/lymphoproliferative disorders - cases of adult T cell leukaemia lymphoma masquerading as other T cell lymphomas/lymphoproliferative disorders could explain some apparent ethnic disparities, British Journal of Haematology, Vol:185, ISSN:0007-1048, Pages:328-330

Webster P, Dawes JC, Dewchand H, et al., 2019, Subclonal mutation selection in mouse lymphomagenesis identifies known cancer loci and suggests novel candidates (vol 9, 2649, 2018), Nature Communications, Vol:10, ISSN:2041-1723

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