Imperial College London
Alternate

DrKonstantinNikolic

Faculty of Engineering, Department of Electrical and Electronic Engineering

Visiting Professor
 
 
 
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Contact

 

k.nikolic

 
 
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Location

 

Bessemer 420CBessemer BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Mirza:2018:10.1142/S0129065718500065,
author = {Mirza, K and Alenda, A and Eftekhar, A and Grossman, N and Nikolic, K and Bloom, S and Toumazou, C},
doi = {10.1142/S0129065718500065},
journal = {International Journal of Neural Systems},
title = {Influence of cholecystokinin-8 on compound nerve action potentials from ventral gastric vagus in rats},
url = {http://dx.doi.org/10.1142/S0129065718500065},
volume = {28},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Objective:Vagus  Nerve  Stimulation  (VNS)  has  shown  great  promise  as  a  potential  therapy  for  anumber  of  conditions,  such  as  epilepsy,  depression  and  forNeurometabolic  Therapies,  especially  fortreating  obesity.  The  objective  of  this  study  was  to  characterise  the  left  ventral  subdiaphragmaticgastric trunk of vagus nerve (SubDiaGVN) and to analyse the influence of intravenous injection of guthormone cholecystokinin octapeptide (CCK-8) on compound nerve action potential (CNAP) observedon the same branch, with the aim of understanding the impact of hormones on VNS and incorporatingthe methods and results into closed loop implant design.Methods:The  cervical  region  of  the  left  vagus  nerve  (CerVN)  of  male  Wistar  rats  was  stimulatedwith electric current and the elicited CNAPs  were recorded on  the SubDiaGVN under four differentconditions:Control(no injection),Saline,CCK1(100 pmol/kg) andCCK2(1000  pmol/kg) injections.Results:We identified the presence of Aδ, B, C1, C2, C3 and C4 fibres with their respective velocityranges. Intravenous administration of CCKin vivoresults in selective, statistically significant reductionof CNAP components originating from A and B fibres, but with no discernible effect on the C fibresinn=7animals. The affected CNAP components exhibit statistically significant (pSaline−CCK1= 0.02andpSaline−CCK2= 0.007) higher normalized stimulation thresholds.Conclusion:This approach of characterising the vagus nerve can be used in closed loop systems todeterminewhento initiate VNS and also to tune the stimulation dose, which is patient specific andchanges over time.
AU  - Mirza,K
AU  - Alenda,A
AU  - Eftekhar,A
AU  - Grossman,N
AU  - Nikolic,K
AU  - Bloom,S
AU  - Toumazou,C
DO  - 10.1142/S0129065718500065
PY  - 2018///
SN  - 0129-0657
TI  - Influence of cholecystokinin-8 on compound nerve action potentials from ventral gastric vagus in rats
T2  - International Journal of Neural Systems
UR  - http://dx.doi.org/10.1142/S0129065718500065
UR  - http://hdl.handle.net/10044/1/57249
VL  - 28
ER  -
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