Imperial College London

DrKieranO'Dea

Faculty of MedicineDepartment of Surgery & Cancer

Senior Research Fellow
 
 
 
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Contact

 

+44 (0)20 3315 8292k.odea

 
 
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Location

 

G3.43Chelsea and Westminster HospitalChelsea and Westminster Campus

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Summary

 

Summary

I am a Senior Research Fellow in the Critical Care research group based at the Chelsea and Westminster Hospital campus. I joined Imperial College as a postdoctoral researcher in 2001. Prior to this, I obtained a PhD in Malaria Immunology at Imperial, and an MSc in Biochemistry and BSc in Biology from King’s College London.


My main research areas are the systemic inflammatory response to infection (sepsis), major trauma and burns injury, and the roles that myeloid cells play in activation of vascular cells within major organs. I am currently involved in developing in vivo and in vitro research models to identify the pathways of inter-cellular/inter-organ signalling during acute systemic inflammation, with a focus on the role of a subtype of extracellular vesicles, known as microvesicles or microparticles. The trafficking and activity of microvesicles represents a new avenue for targeting and manipulating the host response during acute infection and trauma.


I am a lead investigator in the burns research capacity building project, supported and funded by CW+ Charity for the Chelsea and Westminster Hospital NHS Foundation Trust. I am a course organiser and lecturer in Surgery & Anaesthesia BSc 'Perioperative Medicine' module.

Publications

Journals

Oakley C, Koh M, Baldi R, et al., 2019, Ventilation following established ARDS: a preclinical model framework to improve predictive power, Thorax, ISSN:1468-3296

Zöllner J, Howe LG, Edey LF, et al., 2019, LPS-induced hypotension in pregnancy: The effect of progesterone supplementation, Shock, ISSN:1073-2322

Soni S, O'Dea K, Tan YY, et al., 2019, ATP redirects cytokine trafficking and promotes novel membrane TNF signalling via microvesicles, Faseb Journal, ISSN:0892-6638

Conference

Matsumoto S, Iki Y, Abe M, et al., 2019, Neutrophil-Derived Microvesicles as a Novel Biomarker in Hyperoxic Bronchopulmonary Dysplasia in Mice, International Conference of the American-Thoracic-Society, AMER THORACIC SOC, ISSN:1073-449X

Tan YY, O'Dea KP, Soo AP, et al., 2019, Investigation into the Roles of Circulating Microvesicles Within the Pulmonary Vasculature Using Ex Vivo Isolated Perfused Lung, International Conference of the American-Thoracic-Society, AMER THORACIC SOC, ISSN:1073-449X

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