Research in our laboratory focuses on the molecular mechanism of pain pathways. We employ primary cultures of sensory neurons and macrophages, live cell imaging, and molecular biology.
1. Roles of neuropeptide VGF and its receptor in neuropathic pain.
2. Roles of macrophages in hyper-excitation of sensory neurons.
3. The mechanism of hypersensitisation of sensory neurons in chronic pain conditions.
et al., 2016, Intracellular calcium oscillations in strongly metastatic human breast and prostate cancer cells: control by voltage-gated sodium channel activity., Eur Biophys J
et al., 2015, Macrophage-sensory neuronal interaction in HIV-1 gp120-induced neurotoxicity, British Journal of Anaesthesia, Vol:114, ISSN:0007-0912, Pages:499-508
et al., 2013, A clinically relevant rodent model of the HIV antiretroviral drug stavudine induced painful peripheral neuropathy, Pain, Vol:154, ISSN:0304-3959, Pages:560-575
et al., 2013, Identification of a Receptor for Neuropeptide VGF and Its Role in Neuropathic Pain, Journal of Biological Chemistry, Vol:288, ISSN:0021-9258, Pages:34638-34646
Pristerà A, Baker MD, Okuse K, 2013, Correction: Association between Tetrodotoxin Resistant Channels and Lipid Rafts Regulates Sensory Neuron Excitability., Plos One, Vol:8