Imperial College London

DrKenjiOkuse

Faculty of Natural SciencesDepartment of Life Sciences

Senior Lecturer
 
 
 
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Contact

 

+44 (0)20 7594 5742k.okuse Website

 
 
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Location

 

407Sir Ernst Chain BuildingSouth Kensington Campus

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Summary

 

Summary

Research in our laboratory focuses on the molecular mechanism of pain pathways. We employ primary cultures of sensory neurons and macrophages, live cell imaging, and molecular biology.

1. Roles of neuropeptide VGF and its receptor in neuropathic pain.

2. Roles of macrophages in hyper-excitation of sensory neurons.

3. The mechanism of hypersensitisation of sensory neurons in chronic pain conditions.

 

 

Visualising action potential propagation

Visualising action potential propagation

Publications

Journals

Rizaner N, Onkal R, Fraser SP, et al., 2016, Intracellular calcium oscillations in strongly metastatic human breast and prostate cancer cells: control by voltage-gated sodium channel activity, European Biophysics Journal With Biophysics Letters, Vol:45, ISSN:0175-7571, Pages:735-748

Moss PJ, Huang W, Dawes J, et al., 2015, Macrophage-sensory neuronal interaction in HIV-1 gp120-induced neurotoxicity, British Journal of Anaesthesia, Vol:114, ISSN:0007-0912, Pages:499-508

Chen Y-C, Pristera A, Ayub M, et al., 2013, Identification of a Receptor for Neuropeptide VGF and Its Role in Neuropathic Pain, Journal of Biological Chemistry, Vol:288, ISSN:0021-9258, Pages:34638-34646

Huang W, Calvo M, Karu K, et al., 2013, A clinically relevant rodent model of the HIV antiretroviral drug stavudine induced painful peripheral neuropathy, Pain, Vol:154, ISSN:0304-3959, Pages:560-575

Patents

Okuse K, Ayub M, Swanwick R, et al., 2013, New receptor identified for neuropathic pain

More Publications