Imperial College London

DrKathleenO'Reilly

Faculty of MedicineSchool of Public Health

Honorary Research Fellow
 
 
 
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Contact

 

+44 (0)20 7594 3217k.oreilly Website

 
 
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Location

 

G27Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Publication Type
Year
to

18 results found

O'Reilly KM, Verity R, Durry E, Asghar H, Sharif S, Zaidi SZ, Wadood MZM, Diop OM, Okayasu H, Safdar RM, Grassly NCet al., 2018, Population sensitivity of acute flaccid paralysis and environmental surveillance for serotype 1 poliovirus in Pakistan: an observational study, BMC INFECTIOUS DISEASES, Vol: 18, ISSN: 1471-2334

JOURNAL ARTICLE

Imran H, Raja D, Grassly NC, Wadood MZ, Safdar RM, O'Reilly KMet al., 2018, Routine immunization in Pakistan: comparison of multiple data sources and identification of factors associated with vaccination, INTERNATIONAL HEALTH, Vol: 10, Pages: 84-91, ISSN: 1876-3413

JOURNAL ARTICLE

Molodecky NA, Blake IM, O'Reilly KM, Wadood MZ, Safdar RM, Wesolowski A, Buckee CO, Bandyopadhyay AS, Okayasu H, Grassly NCet al., 2017, Risk factors and short-term projections for serotype-1 poliomyelitis incidence in Pakistan: A spatiotemporal analysis, PLOS MEDICINE, Vol: 14, ISSN: 1549-1676

JOURNAL ARTICLE

O'Reilly KM, Lamoureux C, Molodecky NA, Lyons H, Grassly NC, Tallis Get al., 2017, An assessment of the geographical risks of wild and vaccine-derived poliomyelitis outbreaks in Africa and Asia, BMC INFECTIOUS DISEASES, Vol: 17, ISSN: 1471-2334

JOURNAL ARTICLE

Pons-Salort M, Molodecky NA, O'Reilly KM, Wadood MZ, Safdar RM, Etsano A, Vaz RG, Jafari H, Grassly NC, Blake IMet al., 2016, Population Immunity against Serotype-2 Poliomyelitis Leading up to the Global Withdrawal of the Oral Poliovirus Vaccine: Spatio-temporal Modelling of Surveillance Data, PLOS MEDICINE, Vol: 13, ISSN: 1549-1676

JOURNAL ARTICLE

O'Reilly KM, Cori A, Durry E, Wadood MZ, Bosan A, Aylward RB, Grassly NCet al., 2015, A New Method for Estimating the Coverage of Mass Vaccination Campaigns Against Poliomyelitis From Surveillance Data, AMERICAN JOURNAL OF EPIDEMIOLOGY, Vol: 182, Pages: 961-970, ISSN: 0002-9262

JOURNAL ARTICLE

Parker EPK, Molodecky NA, Pons-Salort M, O'Reilly KM, Grassly NCet al., 2015, Impact of inactivated poliovirus vaccine on mucosal immunity: implications for the polio eradication endgame, EXPERT REVIEW OF VACCINES, Vol: 14, Pages: 1113-1123, ISSN: 1476-0584

JOURNAL ARTICLE

De Maio N, Wu C-H, O'Reilly KM, Wilson Det al., 2015, New Routes to Phylogeography: A Bayesian Structured Coalescent Approximation, PLOS GENETICS, Vol: 11, ISSN: 1553-7404

JOURNAL ARTICLE

Metcalf CJE, Tatem A, Bjornstad ON, Lessler J, O'Reilly K, Takahashi S, Cutts F, Grenfell BTet al., 2014, Transport networks and inequities in vaccination: remoteness shapes measles vaccine coverage and prospects for elimination across Africa, Epidemiology and Infection, Vol: 143, Pages: 1457-1466, ISSN: 1469-4409

Measles vaccination is estimated to have averted 13·8 million deaths between 2000 and 2012.Persisting heterogeneity in coverage is a major contributor to continued measles mortality, and abarrier to measles elimination and introduction of rubella-containing vaccine. Our objective is toidentify determinants of inequities in coverage, and how vaccine delivery must change to achieveelimination goals, which is a focus of the WHO Decade of Vaccines. We combined estimates oftravel time to the nearest urban centre (550 000 people) with vaccination data from DemographicHealth Surveys to assess how remoteness affects coverage in 26 African countries. Building on astatistical mapping of coverage against age and geographical isolation, we quantified howmodifying the rate and age range of vaccine delivery affects national coverage. Our scenarioanalysis considers increasing the rate of delivery of routine vaccination, increasing the target agerange of routine vaccination, and enhanced delivery to remote areas. Geographical isolation plays akey role in defining vaccine inequity, with greater inequity in countries with lower measles vaccinecoverage. Eliminating geographical inequities alone will not achieve thresholds for herd immunity,indicating that changes in delivery rate or age range of routine vaccination will be required. Measlesvaccine coverage remains far below targets for herd immunity in many countries on the Africancontinent and is likely to be inadequate for achieving rubella elimination. The impact of strategiessuch as increasing the upper age range eligible for routine vaccination should be considered.

JOURNAL ARTICLE

O'Reilly KM, 2012, Polio vaccination in Pakistan Reply, LANCET, Vol: 380, Pages: 1645-1646, ISSN: 0140-6736

JOURNAL ARTICLE

O'Reilly KM, Durry E, ul Islam O, Quddus A, Abid N, Mir TP, Tangermann RH, Aylward RB, Grassly NCet al., 2012, The effect of mass immunisation campaigns and new oral poliovirus vaccines on the incidence of poliomyelitis in Pakistan and Afghanistan, 2001-11: a retrospective analysis, LANCET, Vol: 380, Pages: 491-498, ISSN: 0140-6736

JOURNAL ARTICLE

O'Reilly KM, Chauvin C, Aylward RB, Maher C, Okiror S, Wolff C, Nshmirimana D, Donnelly CA, Grassly NCet al., 2011, A Statistical Model of the International Spread of Wild Poliovirus in Africa Used to Predict and Prevent Outbreaks, PLOS MEDICINE, Vol: 8, ISSN: 1549-1676

JOURNAL ARTICLE

O'Reilly KM, Low JC, Denwood MJ, Gally DL, Evans J, Gunn GJ, Mellor DJ, Reid SWJ, Matthews Let al., 2010, Associations between the Presence of Virulence Determinants and the Epidemiology and Ecology of Zoonotic Escherichia coli, APPLIED AND ENVIRONMENTAL MICROBIOLOGY, Vol: 76, Pages: 8110-8116, ISSN: 0099-2240

JOURNAL ARTICLE

O'Reilly KM, Medley GF, Green LE, 2010, The control of Corynebacterium pseudotuberculosis infection in sheep flocks: A mathematical model of the impact of vaccination, serological testing, clinical examination and lancing of abscesses, PREVENTIVE VETERINARY MEDICINE, Vol: 95, Pages: 115-126, ISSN: 0167-5877

JOURNAL ARTICLE

O'Reilly KM, Green LE, Malone FE, Medley GRet al., 2008, Parameter estimation and simulations of a mathematical model of Corynebacterium pseudotuberculosis transmission in sheep, PREVENTIVE VETERINARY MEDICINE, Vol: 83, Pages: 242-259, ISSN: 0167-5877

JOURNAL ARTICLE

O'Reilly KM, Harris MJ, Mendl M, Held S, Moinard C, Statham P, Marchant-Forde J, Green LEet al., 2006, Factors associated with preweaning mortality on commercial pig farms in England and Wales, VETERINARY RECORD, Vol: 159, Pages: 193-196, ISSN: 0042-4900

JOURNAL ARTICLE

O'Reilly KM, Green MJ, Peeler EJ, Fitzpatrick JL, Green LEet al., 2006, Investigation of risk factors for clinical mastitis in British dairy herds with bulk milk somatic cell counts less than 150,000 cells/ml, VETERINARY RECORD, Vol: 158, Pages: 649-653, ISSN: 0042-4900

JOURNAL ARTICLE

Malone FE, Fee SA, Kamp EM, King DC, Baird GJ, O'Reilly KM, Murdock FEAet al., 2006, A serological investigation of caseous lymphadenitis in four flocks of sheep, Irish Veterinary Journal, Vol: 59, Pages: 19-21, ISSN: 1393-3817

A double antibody sandwich ELISA developed by ID-DLO, Lelystad to detect Corynebacterium pseudotuberculosis infection was used on 329 sheep from four pedigree Suffolk flocks in which clinical cases of caseous lymphadenitis (CLA) had occurred. At subsequent necropsy, typical CLA lesions were seen in 133 sheep, and the diagnosis was confirmed on culture. Lesions were most commonly seen in lungs (n = 46), parotid lymph nodes (n = 44), prescapular lymph nodes (n = 38) and mediastinal lymph nodes (n = 31). The sensitivity of the ELISA test for detecting culture-positive sheep was 0.88, while the specificity of the test was 0.55. The antibody ELISA detected 87.5 per cent of sheep that had CLA lesions restricted to internal organs only. It was concluded that the ELISA test has a valuable role in detecting sheep with both clinical and subclinical CLA.

JOURNAL ARTICLE

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